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Search Results - technology+classifications+%3e+medical+%3e+oncology
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Brain Cancer: Novel Prognostic Method and Therapeutic Target for Glioblastoma
Advantages: A precision-guided method for identifying glioblastoma-related genes that improves assessment of the current prognostic biomarker Enables the identification of potential novel therapeutic targets: GLP1R agonists, which are already used for managing obesity and type 2 diabetes, could be explored as treatments for GBM Broader Applications:...
Published: 3/24/2025
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Inventor(s):
George Blanck
,
Teresa Thomas
Keywords(s):
Cancer Diagnostics
,
Medical Diagnostics
,
Oncology
,
Therapeutics
Category(s):
Technology Classifications > Cancer > Cancer Diagnostics
,
Technology Classifications > Medical > Medical Diagnostics
,
Technology Classifications > Medical > Oncology
,
Technology Classifications > Medical > Therapeutics
Stavudine as a Potential Anticancer Agent for the Treatment of Pancreatic Cancer
Advantages: Repurposes an existing FDA-approved drug Achieves dose-dependent inhibition of ASPC-1 pancreatic cancer cell proliferation May enhance treatment efficacy when combined with standard chemotherapy Summary: Pancreatic cancer remains one of the most lethal malignancies due to late diagnosis, limited treatment efficacy, and a tumor microenvironment...
Published: 3/10/2025
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Inventor(s):
Sadia Noosrat Boshra
,
Mildred Acevedo-Duncan
,
Kirpal Bisht
Keywords(s):
Cancer Treatment Pancreatic Cancer
Category(s):
Technology Classifications > Cancer > Cancer Treatment Adenocarcinomas
,
Technology Classifications > Medical > Oncology
Novel Peptide-Based Inhibitors of HIF-1α for Cancer Therapy
Advantages: Developed helical mimetics of HIF-1α based on sulfonyl-γ-AA peptides that selectively target HIF-1α to target metastasis and therapy resistance in solid tumors. Inhibitors are stable and cell permeable. HC11, HC13, and HC14 sulfonyl-γ-AA peptides efficiently inhibit HIF-1α activity and reduce expression...
Published: 9/3/2024
|
Inventor(s):
Jianfeng Cai
,
Sami Abdulkadir
Keywords(s):
Cancer Treatment
Category(s):
Technology Classifications > Medical > Biotechnology
,
Technology Classifications > Medical > Oncology
Targeting CREB-Heparan Sulfate Pathway for Cancer Treatment
Advantages: This research contributes to a better understanding of the molecular mechanisms underlying the development and progression of PCa. The study identifies a specific signaling pathway involving Pten loss, CREB, and HS that plays a crucial role in promoting prostate tumorigenesis. The study explores potential therapeutic interventions,...
Published: 1/31/2025
|
Inventor(s):
Hua Yang
,
Lianchun Wang
Keywords(s):
Cancer Treatment
Category(s):
Technology Classifications > Medical > Oncology
,
Technology Classifications > Medical > Pharmaceuticals
,
Technology Classifications > Medical > Therapeutics
Methods for the Treatment of Inflammation
Advantages: Exceptional precision in addressing inflammation, minimizing potential side effects. Unique COX-2 interaction reduces the risk of adverse reactions. Versatile effectiveness across various inflammatory disorders, providing relief to a wide range of patients. Summary: This technology addresses a significant healthcare challenge...
Published: 11/7/2024
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Inventor(s):
Bill Baker
,
Sofia Kokkaliari
,
James Leahy
,
Wayne Williams
Keywords(s):
Inflammation
,
Pain Relief / Management
Category(s):
Technology Classifications > Medical > Biotechnology
,
Technology Classifications > Medical > Oncology
SHIP-1 Agonists for Pancreatic Cancer Treatment
Advantages: SHIP-1 as a new molecular target to improve anti-tumor immunity and enhance immune checkpoint immunotherapy responses SHIP-1 agonists API and K306 as therapeutics for treating pancreatic cancer Combination treatment of a SHIP-1 agonist with a checkpoint inhibitor synergistically reduces tumor burden Summary: Portfolio includes...
Published: 6/11/2024
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Inventor(s):
Tomar Ghansah
Keywords(s):
Biotechnology
,
Cancer Treatment
,
Diagnostics
Category(s):
Technology Classifications > Medical > Oncology
,
Technology Classifications > Medical > Medical Diagnostics
SHIP-1: Biomarker and Therapeutic Target to Reduce Health Disparities in African Americans with Pancreatic Cancer
Advantages: SHIP-1 as a new molecular target to improve anti-tumor immunity and enhance immune checkpoint immunotherapy responses SHIP-1 agonists API and K306 as therapeutics for treating pancreatic cancer Combination treatment of a SHIP-1 agonist with a checkpoint inhibitor synergistically reduces tumor burden Summary: Portfolio included...
Published: 6/11/2024
|
Inventor(s):
Tomar Ghansah
Keywords(s):
Cancer Treatment
Category(s):
Technology Classifications > Medical > Therapeutics
,
Technology Classifications > Medical > Oncology
RNA Aptamer Targeting of ADAM8 in the Tumor Microenvironment
Advantages: Novel targeted RNA aptamers to inhibit ADAM8 and block cancer associated fibroblast maintenance in the tumor microenvironment. RNA aptamer benefits: high affinity, high specificity, and low immunogenicity Promising preclinical in vitro and in vivo outcomes Summary: This research delves into the intricate dynamics of cancer progression,...
Published: 11/21/2024
|
Inventor(s):
Paul Kuo
,
Zhiyong Mi
Keywords(s):
Cancer Treatment
,
Medical Therapeutics Cell Therapy
,
Medical Therapeutics Gene Therapy
Category(s):
Technology Classifications > Medical > Pharmaceuticals
,
Technology Classifications > Medical > Oncology
,
Technology Classifications > Medical > Therapeutics
,
Technology Classifications > Medical > Biotechnology
,
Technology Classifications > Medical > Cell & Tissue Engineering
Novel Peptidomimetics for the treatment of Doxorubicin-Induced Cardiomyopathy
Advantages: Compounds (peptidomimetic inhibitors) that prevent Doxorubicin-induced cardiomyopathy (DIC) that can occur with cancer chemotherapy Peptide therapeutics have high specificity, potency, and low toxicity when compared to traditional small molecule drugs Potentially enabling cancer patients to receive DOX treatment without compromising...
Published: 1/14/2025
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Inventor(s):
Xueling Ma
Keywords(s):
Biotechnology
,
Cancer Diagnostics
,
Cancer Treatment
Category(s):
Technology Classifications > Medical > Therapeutics
,
Technology Classifications > Medical > Oncology
Method and Apparatus for Generating Anti-Cancer Substances In Situ
Advantages: Targeted and minimally invasive treatment, reducing damage to healthy tissues and systemic side effects. Enhanced drug delivery with localized synthesis, increasing drug concentration at the tumor site. Potential for improved patient outcomes due to higher drug concentration and focused cancer cell destruction. Summary: This...
Published: 4/26/2024
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Inventor(s):
Albert Kim
,
Seung Song
Keywords(s):
Cancer Treatment
Category(s):
Technology Classifications > Medical > Biomedical Engineering
,
Technology Classifications > Medical > Biotechnology
,
Technology Classifications > Medical > Oncology
,
Technology Classifications > Medical > Therapeutics
,
Technology Classifications > Medical > Medical Devices
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