Search Results - technology+classifications+%3e+medical+%3e+oncology

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Novel Peptide-Based Inhibitors of HIF-1α for Cancer Therapy
­Advantages: Developed helical mimetics of HIF-1α based on sulfonyl-γ-AA peptides that selectively target HIF-1α to target metastasis and therapy resistance in solid tumors. Inhibitors are stable and cell permeable. HC11, HC13, and HC14 sulfonyl-γ-AA peptides efficiently inhibit HIF-1α activity and reduce expression...
Published: 9/3/2024   |   Inventor(s): Jianfeng Cai, Sami Abdulkadir
Keywords(s): Cancer Treatment
Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Oncology
Targeting CREB-Heparan Sulfate Pathway for Cancer Treatment
­Advantages: This research contributes to a better understanding of the molecular mechanisms underlying the development and progression of PCa. The study identifies a specific signaling pathway involving Pten loss, CREB, and HS that plays a crucial role in promoting prostate tumorigenesis. The study explores potential therapeutic interventions,...
Published: 9/19/2024   |   Inventor(s): Hua Yang, Lianchun Wang
Keywords(s): Cancer Treatment
Category(s): Technology Classifications > Medical > Oncology, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Therapeutics
Methods for the Treatment of Inflammation
­Advantages: Exceptional precision in addressing inflammation, minimizing potential side effects. Unique COX-2 interaction reduces the risk of adverse reactions. Versatile effectiveness across various inflammatory disorders, providing relief to a wide range of patients. Summary: This technology addresses a significant healthcare challenge...
Published: 9/3/2024   |   Inventor(s): Bill Baker, Sofia Kokkaliari, James Leahy, Wayne Williams
Keywords(s): Inflammation, Pain Relief / Management
Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Oncology
SHIP-1 Agonists for Pancreatic Cancer Treatment
­Advantages: SHIP-1 as a new molecular target to improve anti-tumor immunity and enhance immune checkpoint immunotherapy responses SHIP-1 agonists API and K306 as therapeutics for treating pancreatic cancer Combination treatment of a SHIP-1 agonist with a checkpoint inhibitor synergistically reduces tumor burden Summary: Portfolio includes...
Published: 6/11/2024   |   Inventor(s): Tomar Ghansah
Keywords(s): Biotechnology, Cancer Treatment, Diagnostics
Category(s): Technology Classifications > Medical > Oncology, Technology Classifications > Medical > Medical Diagnostics
SHIP-1: Biomarker and Therapeutic Target to Reduce Health Disparities in African Americans with Pancreatic Cancer
­Advantages: SHIP-1 as a new molecular target to improve anti-tumor immunity and enhance immune checkpoint immunotherapy responses SHIP-1 agonists API and K306 as therapeutics for treating pancreatic cancer Combination treatment of a SHIP-1 agonist with a checkpoint inhibitor synergistically reduces tumor burden Summary: Portfolio included...
Published: 6/11/2024   |   Inventor(s): Tomar Ghansah
Keywords(s): Cancer Treatment
Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Oncology
RNA Aptamer Targeting of ADAM8 in the Tumor Microenvironment
­Advantages: Novel targeted RNA aptamers to inhibit ADAM8 and block cancer associated fibroblast maintenance in the tumor microenvironment. RNA aptamer benefits: high affinity, high specificity, and low immunogenicity Promising preclinical in vitro and in vivo outcomes Summary: This research delves into the intricate dynamics of cancer progression,...
Published: 5/20/2024   |   Inventor(s): Paul Kuo, Zhiyong Mi
Keywords(s): Cancer Treatment, Medical Therapeutics Cell Therapy, Medical Therapeutics Gene Therapy
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Oncology, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Cell & Tissue Engineering
Novel Biologic Inhibitors to Target Doxorubicin-Induced Cardiomyopathy
­Advantages: Biologics (peptidomimetic inhibitors) that prevent Doxorubicin-induced cardiomyopathy (DIC) that can occur with cancer chemotherapy Peptide therapeutics have high specificity, potency, and low toxicity when compared to traditional small molecule drugs Potentially enabling cancer patients to receive DOX treatment without compromising...
Published: 8/22/2024   |   Inventor(s): Xueling Ma
Keywords(s): Biotechnology, Cancer Diagnostics, Cancer Treatment
Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Oncology
Method and Apparatus for Generating Anti-Cancer Substances In Situ
­Advantages: Targeted and minimally invasive treatment, reducing damage to healthy tissues and systemic side effects. Enhanced drug delivery with localized synthesis, increasing drug concentration at the tumor site. Potential for improved patient outcomes due to higher drug concentration and focused cancer cell destruction. Summary: This...
Published: 4/26/2024   |   Inventor(s): Albert Kim, Seung Song
Keywords(s): Cancer Treatment
Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Oncology, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Medical Devices
Novel Vascular Endothelial Growth Factor Mimetics as Inhibitors or Activators of Angiogenesis
Advantages: Novel helical VEGF mimicking peptides that can inhibit or activate angiogenesis. Mimetics hold promise as therapeutic agents for intervention in angiogenesis-related diseases. The sulfono-γ-AA peptides exhibit remarkable stability against proteolytic hydrolysis, ensuring their durability and effectiveness in biological systems. Summary: Angiogenesis,...
Published: 6/11/2024   |   Inventor(s): Jianfeng Cai, Sami Abdulkadir
Keywords(s): Cancer, Peptides, Therapeutics
Category(s): Technology Classifications > Cancer, Technology Classifications > Medical > Oncology, Technology Classifications > Medical > Therapeutics
AI: Real Data-Driven Analytical Predictive Model For Pancreatic Cancer, Survival Monitoring Indicator, Survival Methodologies
­Competitive Advantages: The inventive model identifies the risk factors, and interaction and predicts the survival time of a pancreatic cancer patient. The analytic survival indicator can be used to evaluate the effectiveness of different treatments given to patients, by identifying if the survival time of the patients is increasing,...
Published: 7/17/2023   |   Inventor(s): Chris Tsokos, Aditya Chakraborty
Keywords(s): Artificial Intelligence, Cancer, Cancer Diagnostics, Drug Treatment Evaluation, Medical Diagnostics
Category(s): Technology Classifications > Cancer > Cancer Diagnostics, Technology Classifications > Cancer > Cancer Treatment Adenocarcinomas, Technology Classifications > Medical > Oncology
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