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A Breakthrough for Corneal Regeneration: Bioengineered Membrane Immerged with Stem Cell Secretome/Extracellular Vesicles
Advantages Donor-Free Alternative: Eliminates the need for donor corneas in treating shallow corneal opacity, utilizes secretomes and/or extracellular vesicles from stem cells to promote natural healing and tissue regeneration Enhanced Healing Performance: Improves wound closure and reduce fibrosis Sustained and controlled Therapeutic Release ...
Published: 9/15/2025   |   Inventor(s): Rohit Sharma, Yiqin Du
Keywords(s): Ophthalmology
Category(s): Technology Classifications > Chemistry, Technology Classifications > Chemistry > Polymers, Technology Classifications > Medical, Technology Classifications > Medical > Biomaterials, Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications > Medical > Ophthalmology
Advancing In Vitro Intestine Models: Smart Polymer-Controlled Peristalsis
Advantages Replicates in vivo peristalsis without external pumps Electrically tunable frequency, amplitude, and waveform Compact, transparent design for real-time imaging Modular, scalable arrays using standard materials Summary Accurate in vitro intestinal models are essential for reliable drug screening, disease research, and microbiome studies,...
Published: 8/28/2025   |   Inventor(s): Rafsan Rashik, Nathan Gallant, Wenbin Mao
Keywords(s): Cell & Tissue Culture & Engineering, Drug Discovery
Category(s): Technology Classifications > Chemistry > Polymers, Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications > Medical > Biomedical Engineering
Methionine Sulfoxide Reductase A (MsrA) Gene Therapy for Retinal Degeneration
Advantaages Targeted Protection Against Oxidative Stress Dual-Vector Delivery System (AAV and Lenti) Simple and scalable plasmid design for efficient production Suitable for major ophthalmology indications: Age-related macular degeneration (AMD), Retinitis pigmentosa, other oxidative stress-related retinal degenerations Summary Oxidative stress...
Published: 8/18/2025   |   Inventor(s): Manas Biswal
Keywords(s): Ophthalmology, Pharmaceuticals
Category(s): Technology Classifications, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals
Reducing Ischemic Kidney Injury Through Synchronization Modulation Electric Field (SMEF)
Advantages SMEF enables ATP regeneration under ischemic conditions Non-invasive, broad-spectrum applicability to multiple cell and tissue types Enhances organ viability during transplantation Broad Applicability: mechanism is relevant to other ischemic injuries (e.g., heart, brain, liver), opening doors to multi-organ applications Summary Kidney...
Published: 8/8/2025   |   Inventor(s): Wei Chen, Ruisheng Liu
Keywords(s): Organ Transplantation, Renal / Kidney
Category(s): Technology Classifications > Medical > Cell & Tissue Engineering
A Microfluidic-coupled in vitro Model of the Blood-Brain Barrier (BBB)
Advantages Real-time trans endothelial electrical resistance (TEER) monitoring: embedded Ag/AgCl electrodes enables high-resolution impedance spectroscopy, outperforming conventional models Physiologically relevant tri-culture design: microfluidic flow mimics in vivo BBB hemodynamics with spatially separated HUVECs, astrocytes, and pericytes Enhanced...
Published: 6/5/2025   |   Inventor(s): Shyam Mohapatra, Subhra Mohapatra, Tao Wang, Taylor Martinez
Keywords(s):  
Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications, Technology Classifications > Research Tools/Copyright, Technology Classifications > Medical > Neuroscience
Method for Co-Localizing Two Proteins on the Inside of the Cell Membrane in Yeast
Advantages Localization of protein interactions at the cell membrane offers a more physiologically relevant model Improved screening by minimizing off-target interactions Broadly applicable and accessible tools Summary Protein-protein interactions involving membrane proteins are notoriously difficult to study under physiologically relevant conditions....
Published: 5/30/2025   |   Inventor(s): Lawrence Stern, Michael Nelson
Keywords(s): Drug Discovery
Category(s): Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Biomaterials
Novel Cell Lines and Mouse Model to Study Congenital Heart Defects
Advantages: Mutant mouse lines with various CDK13 mutations Identified cardiac specific CDK13 mutations which mirror heart defect development Genetically modified human induced pluripotent stem cells can be differentiated into different cardiac cell types Provides method for screening potential therapeutic agents for congenital heart defects Summary: Congenital...
Published: 7/23/2025   |   Inventor(s): Joanne Chan, DaZhi Wang
Keywords(s): Animal Models, Cardiovascular Diseases, Cell & Tissue Culture & Engineering
Category(s): Technology Classifications > Medical > Cell & Tissue Engineering
New Target for Heart Failure Therapies: Modifying MRPS5/ATF4 Signaling in Cardiomyocytes
Advantages: Identification of MRPS5 as a Therapeutic Target: Reduction of MRPS5 expression stimulates cardiomyocyte proliferation and enhances heart function Discovery of the MRPS5 signaling axis: Decreased MRPS5 enhances ATF4 and Knl1, which promote cardiomyocyte, boosting cardiac recovery after myocardial injury Improved Survival and Cardiac...
Published: 1/17/2025   |   Inventor(s): Da-Zhi Wang, John Mably
Keywords(s): Biotechnology, Cardiological Diseases Treatment, Cell & Tissue Culture & Engineering, Medical Diagnostics, Pharmaceuticals
Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications > Medical > Pharmaceuticals
Kcnab2 Conditional Knockout Mouse Model
­Advantages: A new Kcnab2 exon 4-floxed mice, suitable for experimental models to study muscle development, regeneration, and pathogenesis Kcnab2 exon 4-floxed mice were successfully generated using CRISPR/Case9 technology Allows for specific study of the Kcanb2 function on skeletal muscle (e.g. TA) without significant changes in the brain...
Published: 6/26/2025   |   Inventor(s): Srinivas Tipparaju
Keywords(s): Animal Models, Cardiological Diseases Treatment, Cardiovascular Diseases
Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Cell & Tissue Engineering
Clk1 Inhibitor for White to Brite Adipogenesis
­Advantages: Stimulates mitochondria and reprograms adipocytes from white to beige characteristics. Reduces metabolic disorder inducing white adipose tissue. Burns more energy and stores less fat without changes in lifestyle. Summary: Fat tissue in obesity results from adipocyte hyperplasia or the formation of new adipocytes from progenitors,...
Published: 6/28/2024   |   Inventor(s): Denise Cooper, Robert Sparks, Ryan Kirchoffer, Wayne Guida
Keywords(s):  
Category(s): Technology Classifications > Medical > Cell & Tissue Engineering
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