Search Results - wayne+guida

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Clk1 Inhibitor for White to Brite Adipogenesis
­Advantages: Stimulates mitochondria and reprograms adipocytes from white to beige characteristics. Reduces metabolic disorder inducing white adipose tissue. Burns more energy and stores less fat without changes in lifestyle. Summary: Fat tissue in obesity results from adipocyte hyperplasia or the formation of new adipocytes from progenitors,...
Published: 6/28/2024   |   Inventor(s): Denise Cooper, Robert Sparks, Ryan Kirchoffer, Wayne Guida
Keywords(s):  
Category(s): Technology Classifications > Medical > Cell & Tissue Engineering
Development of a Novel Sub Picomolar Method for Microscale Thermophoresis
­Advantages: Cost-effective with minimal sample requirements. Label-free detection preserves native molecular states. Real-time analysis for dynamic interactions. Summary: Microscale thermophoresis (MST) is a method used to detect and analyze interactions between molecules. Current instrument detection limitations dictate that binding events...
Published: 11/8/2024   |   Inventor(s): William Lawless, Robert Sparks, Wayne Guida
Keywords(s): Autoimmune Diseases, Cancer, Drug Discovery
Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Pharmaceuticals
Sortilin-Binding Small Molecule Increases Glucose Uptake
Competitive Advantages Selectively binds to wild-type sortilin Increases cellular glucose uptake Compensates for reduced sortilin activity in obese patients Summary USF inventors have discovered novel therapeutic compounds that have shown to bind favorably to wild-type (WT) sortilin and increase glucose uptake, especially when used...
Published: 8/26/2023   |   Inventor(s): Robert Sparks, Wayne Guida, Niketa Patel
Keywords(s):  
Category(s): Technology Classifications > Medical > Endocrinology, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical