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Ketone for Weight Loss Maintenance
Advantages: R/S 1,3-butanediol diacetoacetate clinically demonstrated superior weight loss compared to standard rodent chow or ketogenic diet Long-lasting weight maintenance suggests metabolic adaptations compared to typical diet-based approaches Scalable and cost-effective single-agent solution, offering a financial advantage over existing options Summary: Achieving...
Published: 2/26/2025   |   Inventor(s): Dominic D'Agostino, Angela Poff, Andrew Koutnik
Keywords(s): Nutrition / Diet Health
Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Chemistry
Antimicrobial Terpenes From a Deep-Sea Irish Coral
Advantages: A novel structural diversity (anthoteibinenes A-Q) offers bioactive scaffolds, absent in standard combinatorial chemistry libraries Anthoteibinenes I and J have demonstrated activity against multiple Candida strains, indicating possible antibacterial efficacy Selective bioassay- and NMR-guided isolation provides a more targeted approach...
Published: 2/21/2025   |   Inventor(s): Bill Baker, Stine Olsen, Mark Johnson, Louise Allcock, Sam Afoullouss, Ezequiel Rosa, Ryan Young
Keywords(s):  
Category(s): Technology Classifications > Chemistry, Technology Classifications > Medical, Technology Classifications > Medical > Pharmaceuticals
Prevention of Abnormal Uterine Bleeding Caused by Progestin-Only Long-Acting Reversible Contraceptives
Advantages: 15dPGJ2 blocks the proliferation of human endometrial endothelial cells, thereby preventing pLARC-induced aberrant endometrial angiogenesis, a major cause of unexpected uterine bleeding 15dPGJ2 enhances progestin responsiveness and prevents pLARC-induced inflammation, another contributor to uterine vascular instability, effectively reducing...
Published: 2/19/2025   |   Inventor(s): Charles Lockwood, Ozlem Guzeloglu-Kayisli, Umit Kayisli
Keywords(s): Women’s Health
Category(s): Technology Classifications > Medical, Technology Classifications > Chemistry, Technology Classifications > Medical > Pharmaceuticals
Colorectal Cancer Gene Expression Signature as a Predictor for Therapy Outcomes
Advantages: Novel biomarker development: Unique 10-gene signatures distinguish the contributions of tumor epithelium (EPI) & tumor microenvironment (TME) in colorectal cancer (CRC) Clinical Relevance: EPIS signature predicts better progression-free survival in cetuximab-treated metastatic CRC patients; TMES correlates with worse survival outcomes Enhanced...
Published: 2/12/2025   |   Inventor(s): Timothy Yeatman, Mingli Yang
Keywords(s): Cancer Treatment, Pharmaceuticals
Category(s): Technology Classifications > Cancer, Technology Classifications > Medical, Technology Classifications > Chemistry
The Edema Ruler
Advantages: The 3D-printed edema ruler provides accurate 1-mm increment markings for quantifiable, reliable measurements Standardized pressure application and clear markings yield high intraclass correlation coefficients for both single and average measurements Significantly cheaper than equipment-intensive options and the 3D-printed PLA construction...
Published: 2/4/2025   |   Inventor(s): Maysen Calzon
Keywords(s):  
Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Medical Devices
A Novel Preclinical Model of Neonatal Necrotizing Enterocolitis
Advantages: Uniquely replicates the clinical scenario of RBC transfusion-exacerbated NEC in anemic neonates, providing a more accurate model than the traditional method Provide superior mechanistic insights, offering precise investigation of molecular pathways compared to in vitro intestinal injury assays Cost-effective and high-throughput experimentation,...
Published: 1/17/2025   |   Inventor(s): Akhil Maheshwari, Mohan Krishnan
Keywords(s): Animal Models, Research Tools
Category(s): Technology Classifications > Medical
Sensitive and Selective Synthetic Glucose Receptor Designed for Monitoring in Biomedical and Diagnostic Applications
Advantages: Highly sensitive glucose sensor with strong potential for use in biomedical diagnostics and continuous glucose monitoring. Flexible, adaptive binding pocket that selectively targets glucose’s functional groups, improving specificity and detection accuracy. Reversible, non-covalent binding to glucose, allowing real-time response...
Published: 1/17/2025   |   Inventor(s): Wenqi Liu
Keywords(s): Biotechnology, Diabetes, Pharmaceuticals
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical
Vaccine Candidate for Preventing Clostridioides difficile Infection: Cell Wall Protein 2 (CWP 2)
­Advantages: A recombinant Cwp2 protein that induces strong IgG and IgA antibody response in animal models. Decrease levels of C. difficile spores and toxins in feces and decrease mortality rates in immunized mice. Anti-Cwp2 antibodies delay the binding of C. difficile vegetative cells to human gut epithelial cells and prevent bacterial colonization....
Published: 1/31/2025   |   Inventor(s): Xingmin Sun, Shaohui Wang
Keywords(s): Vaccines
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical, Technology Classifications > Medical > Biotechnology
Drug-Induced Activation of the Reelin Signaling System
­Advantages: Small, soluble drug with therapeutic potential Independent Reelin signaling pathway activation More able to pass through the BBB than Reelin Summary: The Reelin signaling pathway is an essential component of the developing and adult central nervous systems. The signaling cascade assists with the regulation of developing neurons...
Published: 7/24/2024   |   Inventor(s): Edwin Weeber, Melinda Peters, Qingyou Li, Hana Soueidan
Keywords(s):  
Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Neuroscience
Burn Care: Topical Formulations for Treatment of Hypergranulation Tissue
­Advantages: Inexpensive and easily manufactured. Fast acting with improvement in the first 72 hours after treatment. No adverse side effects. Summary: Hypergranulation tissue is an excessive growth of granulation tissue in a wound and is a problem that can be encountered in burn care when wounds take a significant time to heal at burn sites...
Published: 1/14/2025   |   Inventor(s): Wlliam West
Keywords(s): Dermatology / Skin, Wound and Tissue Healing
Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Therapeutics
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