Search Results - ozlem+guzeloglu-kayisli

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DNAzyme-based biosensor technology for selective and real-time detection of potassium ions in biological systems
Background The ability to monitor potassium ion (K+) dynamics is of critical importance, particularly in the context of cancer research and neurobiology. Potassium ions play a fundamental role in maintaining cellular homeostasis, regulating membrane potential, and influencing processes such as cell proliferation, apoptosis, and immune responses. Disruptions...
Published: 1/27/2026   |   Inventor(s): Yi Lu, Zhenglin Yang, Xiangli Shao, Yuting Wu
Keywords(s):  
Category(s): Life sciences > Biomaterials, Life sciences > Research tools > Tool/assay/screening platform
Transgenic Mouse Model for Marfan Syndrome Research
Description: A genetically modified mouse model carrying the FBN1Q2469X mutation enables advanced study of systemic Marfan Syndrome manifestations and therapeutic development. This innovative transgenic mouse model incorporates a mutation analogous to the human FBN1Q2467X gene mutation linked to Marfan Syndrome, resulting in fibrillin-1 deficiency...
Published: 12/23/2025   |   Inventor(s): Li Li, Shichao Wu, Jiawei Zhao
Keywords(s):  
Category(s): Technology Category > Research tools, Technology Category > Animal models, Technology Category > Biology, Technology Category > Diagnostic
DNAzyme-seq: a single-cell metal ion and transcriptome profiling platform
Background Metal ions such as zinc, copper, and calcium play indispensable roles in nearly every facet of cellular physiology, from enzymatic catalysis to signal trans­duction. However, conventional single-cell transcriptomics has largely over­looked the contribution of metal cofactors to gene expression, metabolism, and disease progression....
Published: 1/13/2026   |   Inventor(s): Yi Lu, Mandira Banik, Valeria Garcia, Ishika Rashed
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Immunology > Genomics/genetics
Biocompatible photoenzymatic system for selective C–H fluorination
Background C–H fluorination plays a central role in pharmaceutical and agrochemical synthesis, as the introduction of fluorine often enhances a molecule's metabolic stability, potency, and bioavailability. Over 20% of approved drugs contain fluorinated functional groups, underscoring the demand for efficient and selective fluorination methods....
Published: 1/13/2026   |   Inventor(s): Yi Lu, Yu Zhou
Keywords(s):  
Category(s): Life sciences > Metabolic engineering
DNA-based sensors for live-cell mapping of metabolite- and metal ion-protein interactions
Background Understanding how metabolites and metal ions interact with proteins inside living cells is essential for decoding cellular signaling, metabolic regulation, and disease mechanisms. These small molecules function as cofactors, second messengers, and allosteric regulators, orchestrating critical pathways that govern cell behavior. However,...
Published: 1/13/2026   |   Inventor(s): Yi Lu, Mandira Banik
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Immunology > Genomics/genetics
Artificial nitrogenase enzymes for ambient-condition, decentralized ammonia production
Background Ammonia synthesis is foundational to global agriculture and chemical manufacturing, providing the primary source of fixed nitrogen for fertilizers, polymers, and pharmaceuticals. Traditional ammonia production through the Haber-Bosch process, however, operates under extreme conditions—temperatures exceeding 400°C and pressures...
Published: 1/13/2026   |   Inventor(s): Yi Lu, Hirbod Heidari, Markus Ribbe, Yilin Hu, Chi Chung Lee, Evan Mirts
Keywords(s):  
Category(s): Life sciences > Therapeutics > Synthetic biology, Life sciences > Metabolic engineering
New Potential Therapeutic Method for Leiomyoma: Co-Inhibition of FKBP51 and HSD11B1
Advantages: Novel approach for leiomyoma treatment: Direct disruption of the FKBP51-GR-HSD11B1 signaling loop Stronger GR suppression than single-target hormone therapies Targeted leiomyoma treatment: Modulates GR activity, control cortisol production and ECM generation Minimizes hormonal side effects, offering a fertility-friendly alternative...
Published: 10/14/2025   |   Inventor(s): Charles Lockwood, Ozlem Guzeloglu-Kayisli, Carrie Malcom, Umit Kayisli
Keywords(s): Women’s Health
Category(s): Technology Classifications > Medical > Womens Health
Early Screening Method for Fetal Growth Restriction (FGR)
Advantages: Earlier diagnosis than traditional FGR screening: can detect risk as early as the 1st or 2nd trimester Non-invasive testing with maternal blood Superior sensitivity and specificity compared to ultrasound-based detection Can be potentially further developed into a commercial product/ standard prenatal screening test for DNA methylation...
Published: 10/14/2025   |   Inventor(s): Umit Kayisli, Anthony Odibo, Charles Lockwood, Ozlem Guzeloglu-Kayisli
Keywords(s): Women’s Health
Category(s): Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Womens Health
Prevention of Abnormal Uterine Bleeding Caused by Progestin-Only Long-Acting Reversible Contraceptives
Advantages: 15dPGJ2 blocks the proliferation of human endometrial endothelial cells, thereby preventing pLARC-induced aberrant endometrial angiogenesis, a major cause of unexpected uterine bleeding 15dPGJ2 enhances progestin responsiveness and prevents pLARC-induced inflammation, another contributor to uterine vascular instability, effectively reducing...
Published: 2/19/2025   |   Inventor(s): Charles Lockwood, Ozlem Guzeloglu-Kayisli, Umit Kayisli
Keywords(s): Women’s Health
Category(s): Technology Classifications > Medical, Technology Classifications > Chemistry, Technology Classifications > Medical > Pharmaceuticals
DNAzyme sensor for selective manganese ion detection in biological systems
A selective DNAzyme-based fluorescent sensor detects manganese ions in cells by lighting up when Mn²⁺ binds, allowing precise monitoring of manganese levels for biological research and potential therapies. Background Manganese (Mn²⁺) is an essential trace element integral to numerous biological processes, acting as a vital cofactor for enzymes...
Published: 1/13/2026   |   Inventor(s): Yi Lu, Zhenglin Yang, Huanhuan Fan
Keywords(s):  
Category(s): Life sciences > Biomaterials
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