Search Results - ozlem+guzeloglu-kayisli

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ARPLA: a revolutionary glycoRNA imaging tool with precision and power
Background/problem Glycosylated RNAs (GlycoRNAs) are a newly discovered class of molecules involved in glycosylation. They have been found on the surfaces of various cell types, organisms, and species, further advancing the role of RNA in biological processes. Despite this, our knowledge of glycoRNAs and their functions remains limited, primarily...
Published: 7/26/2024   |   Inventor(s): Yi Lu, Yuan Ma, Weijie Guo, Quanbing Mou
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform
Ophthalmological Formulations for the Prevention of a Coronavirus Infection
­Advantages: Directly delivers remdesivir in ophthalmic drops to the eye cells potentially minimizing systemic side effects. Formulation is designed to prevent disease transmission via the eyes and to treat conjunctivitis caused by infection. Nanoparticulate formulation meets pharmaceutical delivery standards. Summary: COVID-19, caused...
Published: 7/17/2024   |   Inventor(s): Vijaykumar Sutariya, Srinivas Tipparaju, Kevin Sneed, Manas Biswal, Ozlem Guzeloglu-Kayisli, Ramesh Ayyala, Radouil Tzekov
Keywords(s):  
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Ophthalmology, Technology Classifications > Medical > Medical Nanotechnology, Technology Classifications > Medical > Medical Diagnostics
Convolutional Neural Networks for Organ Segmentation
Abstract: Accurate automated organ and disease feature segmentation is a challenge for medical imaging analysis. The pancreas, for example, is a small, soft, organ with low uniformity of shape and volume between patients. Because of the lack of uniform image patterns, there are few features that can be used to aid in automated identification of anatomy...
Published: 4/8/2024   |   Inventor(s): Holger Roth, Le Lu, Adam Harrison, Ronald Summers
Keywords(s): Computer Assisted Diagnostics, Computer Vision, Deep Learning, HNN, Holistically-Nested Convolutional Neural Network, Medical Imaging Informatics, National Institutes of Health Clinical Center, NIHCC
Category(s): Application > Software / Apps, Collaboration Sought > Licensing, Collaboration Sought > Collaboration
Convolutional Neural Networks for Organ Segmentation
Abstract: Accurate automated organ and disease feature segmentation is a challenge for medical imaging analysis. The pancreas, for example, is a small, soft, organ with low uniformity of shape and volume between patients. Because of the lack of uniform image patterns, there are few features that can be used to aid in automated identification of anatomy...
Published: 4/8/2024   |   Inventor(s): Le Lu, Holger Roth, Isabelle-Emmanu Nogues, Ronald Summers, Xiaosong Wang
Keywords(s): Computer Assisted Diagnostics, Computer Vision, Deep Learning, HNN, Holistically-Nested Convolutional Neural Network, Medical Imaging Informatics, National Institutes of Health Clinical Center, NIHCC
Category(s): Application > Software / Apps, Collaboration Sought > Licensing
Learning to Read Chest X-Rays: Recurrent Neural Cascade Model for Automated Image Annotation
Abstract: Medical image datasets are an important clinical resource. Effectively referencing patient images against similar related images and case histories can inform and produce better treatment outcomes. Labeling and identifying disease features and relations between images within a large image database has not been a task capable of automation....
Published: 4/8/2024   |   Inventor(s): Hoo Chang Shin, Le Lu, Ronald Summers
Keywords(s): Chest X-Rays, CNN, Computer Assisted Diagnostics, Convolutional Neural Networks, Deep Learning Model, Disease Mining from Images, Radiology, Recurrent Neural Networks, RNN, Shin
Category(s): Application > Software / Apps, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, TherapeuticArea > Cardiology
Progressive and Multipath Neural Network for Medical Image Segmentation
Abstract: The technology relates to software, systems, and methods for automated medical image segmentation via deep learning. Standard holistically-nested networks (HNNs) used in computer vision and medical imaging for segmentation and edge detection have a problem with coarsening resolution. The described technology addresses this.   Simple, progressive...
Published: 4/8/2024   |   Inventor(s): Adam Harrison, Ziyue Xu, Le Lu, Ronald Summers, Daniel Mollura
Keywords(s): Automated Medical Image, Coarsening Resolution, Computer Assisted Diagnostic, Deep Learning, Diagnostics, Holistically-nested networks (HNNs), Image Segmentation, Medical Imaging, Medical Imaging Processing, Segmentation
Category(s): Collaboration Sought > Collaboration, Application > Software / Apps, Collaboration Sought > Licensing
Method and System of Building Hospital-Scale Medical Image Database
Abstract: Developing computer systems that can recognize and locate image features associated with disease is a challenge for developing fully-automated and high precision computer assisted diagnostics. Joint learning of language tasks in association with vision tasks (association of image features with text annotation) adds an additional level of challenge. ...
Published: 4/8/2024   |   Inventor(s): Xiaosong Wang, Yifan Peng, Le Lu, Zhiyong Lu, Ronald Summers
Keywords(s): Computer Assisted Diagnostics, Computer Vision, Deep Learning, Medical Imaging Informatics, National Institutes of Health Clinical Center, NIHCC, PACS, Picture Archiving and Communication Systems
Category(s): Collaboration Sought > Licensing, Application > Software / Apps
y-AApeptide-based long-acting pan-coronavirus fusion inhibitor with dual targets in spike protein and oral bioavailability
­Advantages: S-20-1 demonstrates potent inhibitory action, this broad-spectrum activity suggests that S-20-1 could be effective against a wide range of coronaviruses, making it a valuable candidate for pandemic preparedness and management. The research provides insights into the mechanism of action of S-20-1, demonstrating its ability to bind...
Published: 9/25/2023   |   Inventor(s): Jianfeng Cai, Shibo JIANG, Lu LU, Songyi XUE, Xinling WANG, Lei WANG, Wei XU, Shuai XIA
Keywords(s): Drug Discovery, Immunology
Category(s): Technology Classifications > Medical > Biotechnology
Neuronal suppression of FKBP51 expression by fatty acid derivatives to prevent mental disorders
­Advantages: The study highlights FKBP51 as a promising target for the treatment of disorders such as major depression, PTSD, anxiety disorders, and Alzheimer's disease. The research recognizes the influence of single nucleotide polymorphisms (SNPs) in the FKBP5 gene on FKBP51 levels and susceptibility to certain disorders. The researchers...
Published: 9/3/2024   |   Inventor(s): Charles Lockwood, Laura Blair, Ozlem Guzeloglu-Kayisli, Umit Kayisli
Keywords(s): Biotechnology, Medical Pharmaceuticals, Neurodegenerative Diseases, Therapeutics
Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Therapeutics
Amphiphilic macromolecules with novel hydrophobic segments
­ ​ ​ Invention Summary: Cardiovascular diseases are the leading cause of mortality in developed countries. Atherosclerosis, defined as the buildup of lipid rich plaques within the vascular intima, is the foremost pathology underlying these conditions. This causes irregular uptake of oxidized low-density lipoproteins (OxLDL) which leads...
Published: 12/4/2024   |   Inventor(s): Kathryn Uhrich, Allison Faig, Dalia Abdelhamid, Li Gu
Keywords(s): Antibacterial, Biomaterials, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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