Search Results - umit+kayisli

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New Potential Therapeutic Method for Leiomyoma: Co-Inhibition of FKBP51 and HSD11B1
Advantages: Novel approach for leiomyoma treatment: Direct disruption of the FKBP51-GR-HSD11B1 signaling loop Stronger GR suppression than single-target hormone therapies Targeted leiomyoma treatment: Modulates GR activity, control cortisol production and ECM generation Minimizes hormonal side effects, offering a fertility-friendly alternative...
Published: 3/12/2025   |   Inventor(s): Charles Lockwood, Ozlem Guzeloglu-Kayisli, Carrie Malcom, Umit Kayisli
Keywords(s): Women’s Health
Category(s): Technology Classifications > Medical > Womens Health
Early Screening Method for Fetal Growth Restriction (FGR)
Advantages: Earlier diagnosis than traditional FGR screening: can detect risk as early as the 1st or 2nd trimester Non-invasive testing with maternal blood Superior sensitivity and specificity compared to ultrasound-based detection Can be potentially further developed into a commercial product/ standard prenatal screening test for DNA methylation...
Published: 3/4/2025   |   Inventor(s): Umit Kayisli, Anthony Odibo, Charles Lockwood, Ozlem Guzeloglu-Kayisli
Keywords(s): Women’s Health
Category(s): Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Womens Health
Prevention of Abnormal Uterine Bleeding Caused by Progestin-Only Long-Acting Reversible Contraceptives
Advantages: 15dPGJ2 blocks the proliferation of human endometrial endothelial cells, thereby preventing pLARC-induced aberrant endometrial angiogenesis, a major cause of unexpected uterine bleeding 15dPGJ2 enhances progestin responsiveness and prevents pLARC-induced inflammation, another contributor to uterine vascular instability, effectively reducing...
Published: 2/19/2025   |   Inventor(s): Charles Lockwood, Ozlem Guzeloglu-Kayisli, Umit Kayisli
Keywords(s): Women’s Health
Category(s): Technology Classifications > Medical, Technology Classifications > Chemistry, Technology Classifications > Medical > Pharmaceuticals
Neuronal suppression of FKBP51 expression by fatty acid derivatives to prevent mental disorders
­Advantages: The study highlights FKBP51 as a promising target for the treatment of disorders such as major depression, PTSD, anxiety disorders, and Alzheimer's disease. The research recognizes the influence of single nucleotide polymorphisms (SNPs) in the FKBP5 gene on FKBP51 levels and susceptibility to certain disorders. The researchers...
Published: 1/17/2025   |   Inventor(s): Charles Lockwood, Laura Blair, Ozlem Guzeloglu-Kayisli, Umit Kayisli
Keywords(s): Biotechnology, Medical Pharmaceuticals, Neurodegenerative Diseases, Therapeutics
Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Therapeutics
Novel target to treat the growth of uterine leiomyomas
Advantages: Our investigators have identified restricted patterns of CD73 expression that broadly implicate extracellular adenosine as a key mediator for the growth of uterine leiomyomas. Targeting activity at Type2B adenosine receptors could be potentially used as a strategy to shrink leiomyomas while avoiding potential limitation and systemic...
Published: 9/3/2024   |   Inventor(s): Matthew Anderson, Xiaofang Guo, Umit Kayisli
Keywords(s): Cancer Diagnostics, Cancer Treatment, Women’s Health
Category(s): Technology Classifications > Cancer > Cancer Diagnostics
PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids
The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...
Published: 2/18/2025   |   Inventor(s): Payman Dehghanian, Shiyuan Wang, Li Li
Keywords(s):  
Category(s): Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment
Distributed Feedback Fiber Laser Pumped by Multimode Diode Lasers
Researchers at the University of Arizona College of Optical Sciences and Canada's Carleton University recently succeeded in fabricating high reflectivity (>99%) Fiber Bragg Gratings (FBGs) into phosphate glass fibers using UV light and a phase mask technique. With this new manufacturing technique, fiber lasers can be created as single monolithic...
Published: 4/3/2023   |   Inventor(s): Nasser Peyghambarian, Axel Schülzgen, Li Li, Jacques Albert
Keywords(s):  
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Lasers & Other Sources
All-Fiber Multicore Fiber Laser Devices
Researchers at the University of Arizona have developed a compact, power-scalable, alignment-free fiber laser that takes a new approach to stabilizing phase-locked operation of multi-core fiber lasers by completely removing all free space optical components. This high-brightness, all-fiber laser package uses passive optical fiber spliced at both ends...
Published: 4/3/2023   |   Inventor(s): Nasser Peyghambarian, Axel Schülzgen, Li Li
Keywords(s):  
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Fiber Optics, Technology Classifications > Imaging & Optics > Lasers & Other Sources