Search Results - yanmin+zhang

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Selective Mitochondrial Imaging and Therapeutic Targeting
It is becoming increasingly apparent that mitochondrial dysfunction plays a critical role in numerous human diseases. Yet, there are no approved drugs designed to directly target mitochondria. To develop new therapeutics that target mitochondria, ideally, a mitochondrial targeting moiety would be utilized. Although several functionalities have been...
Published: 1/25/2024   |   Inventor(s): Arnaud Chevalier, Sidney Hecht, Yanmin Zhang, Omar Khdour
Keywords(s):  
Category(s): Bioanalytical Assays, Chemistries & Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors
Potent and Selective Inhibition of a Single AMPA Receptor Subunit by an RNA Aptamer
Inhibitors of AMPA type glutamate ion channels for the treatment of neurological disorders such as ALS, Alzheimer's, and Parkinson's. <.HDBackground>Background: Ionotropic glutamate receptors (iGluRs) play special roles in brain activities, such as memory and learning, and have been implicated in a variety of neurological diseases,...
Published: 1/29/2024   |   Inventor(s): Li Niu, Zhen Huang, Yan Han, Congzhou Wang, Jae Seon Park
Keywords(s): RNA, Technologies
Category(s): Technology Classifications > Biomedical Science and Engineering, Campus, Campus > University at Albany
Method for 3D Nonlinear Structured Illumination Super-resolution Imaging
Researchers at the University of Arizona have developed a super-resolution microscopy method that is faster, easier to use, and has less artifacts than current super-resolution methods. The result is a 3D dual-color stimulated emission depletion (STED) nonlinear structured illumination (NL-SIM) microscope. Using a combination of low coherent light and...
Published: 4/3/2023   |   Inventor(s): Leilei Peng, Yu Li, Han Zhang
Keywords(s):  
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Imaging & Optics > Microscopy, Spectroscopy, Polarimetry
Helical Sulfono-γ-AApeptide Antagonize β-Catenin Signaling
Competitive Advantages Potent, specific, and cell permeable to target intracellular PPIs High stability against enzymatic degradation More effective than other peptides at antagonizing Wnt/β-catenin signaling Summary Protein-protein interactions (PPIs) are vital to the survival of cancer cells and are therefore a good target for anti-cancer...
Published: 7/17/2023   |   Inventor(s): Jianfeng Cai, Peng Sang, Yan Shi, Haitao Ji, Min Zhang
Keywords(s): Cancer, Cancer Treatment Leukemias, Cancer Treatment Lymphomas, Peptides, Therapeutics
Category(s): Technology Classifications > Cancer
Compositions for Treatment of HER2 Positive Cancers
Many early stage cancers have a high rate of survival if promptly diagnosed and treated. Survival rates for stage 1-3 breast cancer can be as high as 95% at the 5 year mark. Unfortunately, late stage cancers have a much lower survival rate; stage 4 breast cancer only has about a 20% survival rate at the 5 year mark. Metastatic cancers pose a particularly...
Published: 2/23/2023   |   Inventor(s): Shengxi Chen, Yanmin Zhang, Sidney Hecht
Keywords(s): Cancer, Chemicals, DNA nanotechnology, Drug Delivery, Peptides
Category(s): Cancer Therapeutics, Life Science (All LS Techs), Pharmaceuticals, Advanced Materials/Nanotechnology
Automated Glomerular Segmentation Pipeline for 3D MRI
Recent studies conclude that a strong correlation exists between the numbers of glomerular in the kidney and renal diseases. These findings generate great interest in accurately counting glomeruli. Traditionally, the glomerulus is counted using histological sections, which have several limitations. First, histology based counting relies on techniques...
Published: 2/23/2023   |   Inventor(s): Teresa Wu, Min Zhang
Keywords(s): Algorithm Development, Imaging, Materials and Electronics, Mechanical and Manufacturing, Medical Devices and Imaging, Modeling, Nephrology, Networks, IT, Software and Communication
Category(s): Computing & Information Technology
A System For Visual Presentation Of Concepts From Ontology And Text Documents
PAGE TITLEOverviewPAGE SUMMARYA system lets a user click on a location of a brain model to explore neuroscience ontology terms related to the location. The user can further explore the related terms and related documents through a visualization interface and learn new concept or document relationships derived from the ontology and annotated document...
Published: 7/24/2024   |   Inventor(s): Yuan An, Xia Lin, Mi Zhang, Yue Shang
Keywords(s):  
Category(s): Computing, Software, Analytics & Information Technology, Computing, Software, Analytics & Information Technology > Computing: Algorithms, Computing, Software, Analytics & Information Technology > Computing: Contextual Analytics, Computing, Software, Analytics & Information Technology > Computing: Data Mining, Computing, Software, Analytics & Information Technology > Computing: Databases
Grouping Algorithm for Touchscreen Finger Position Detection (Case No. 2016-520)
Case 2016-520UCLA researchers in the Department of Electrical Engineering developed a new grouping algorithm for touchscreen finger position detection.BACKGROUNDTouchscreen technology plays an important role in the booming mobile devices market. Conventional touchscreens are designed with both horizontal and vertical electrodes. When these sensors are...
Published: 9/10/2024   |   Inventor(s): Mau-Chung Frank Chang, Chunchen Liu, Li Du, Yan Zhang
Keywords(s): Software & Algorithms
Category(s): Software & Algorithms, Software & Algorithms > Programs
Nest DNN, a Pruning-and-Recovery Paradigm for Deep Neural Networks
Executive SummaryNeural networks are employed ubiquitously in our lives today. Found in applications such as video games, face identification, autonomous vehicles navigation, and medical diagnostic tools, these algorithms require a hefty amount of computer resources. In instances where resource demand is greater than availability, accuracy and computational...
Published: 8/20/2022   |   Inventor(s): Mi Zhang, Biyi Fang, Xiao Zeng
Keywords(s):  
Category(s): Computer Software, Data Processing/Analysis, Informatics
Mobile Phone App for Real Time Pill Recognition
Executive SummaryThe ability to quickly and reliably be able to identify both prescription and non-prescription medications is not only important for a patient and his caretaker, but also important for pharmacists, nurses, and law enforcement agents. Despite unique FDA-approved identifiers for each pill, distinguishing the differences can be difficult...
Published: 8/20/2022   |   Inventor(s): Mi Zhang, Kai Cao, Xiao Zeng
Keywords(s):  
Category(s): Medical, Computer Software, Pharmaceutical
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