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Enhanced Radiation Shielding with Conformal Light-weight Nanoparticle-polymer Composite
INV-19025 Background The efficient shielding of ionizing X-ray and gamma radiation is required in medical, nuclear and aerospace industries. High Z elements such as lead, tungsten, bismuth and uranium are often used to attenuate X-ray radiation, where the shielding ability is dependent on the density and mass of the material, leading to heavy shielding...
Published: 9/10/2024   |   Inventor(s): Ming Su
Keywords(s):  
Category(s): -Materials, -Nanotechnology, -Biomedical Materials
High throughput toxicity assay on coordinately ordered single cells with individual identity
INV-18104 Background Cytotoxicity plays an important role in understanding biological mechanisms, detecting diseases, and screening therapeutics. Cytotoxicity measurement is usually carried out by incubating cells in different sized wells with a specific treatment, which yields results based on the average response of cells in the same well. However,...
Published: 9/10/2024   |   Inventor(s): Ming Su, Qingxuan Li, Liyuan Ma
Keywords(s):  
Category(s): Technology Classifications > 1. Life Science > Therapeutics, Technology Classifications > 1. Life Science > Drug Discovery
A Programmable Digitally Controlled Point-of-Load DC-DC Buck Converter Suitable for Space Applications
Buck converters are essential to modern electronics as they can maintain an output voltage at a desired range. Two of the main methods to accomplish this are hysteretic control and pulse width modulation (PWM). Hysteretic controllers continually monitor the output voltage and adjust it if it is too high or too low, but have bad frequency control. On...
Published: 2/23/2023   |   Inventor(s): Bertan Bakkaloglu, Ming Sun, Philippe Adell
Keywords(s): Fuel Cells, Energy, Materials and Electronics
Category(s): Computing & Information Technology, Physical Science
Assay for Non-Nucleoside Inhibitors of the Measles and Nipah Viruses
Application A cell-based assay to screen for inhibitors of the measles virus (MV). Highly active compounds have been identified and analogs have been synthesized and evaluated. Key Benefits Potent (sub-nM range), non-peptidic, non-nucleosidic compounds. Robust, cell-based, high-throughput screening assay. Technical Summary Vaccination serves...
Published: 12/4/2024   |   Inventor(s): Richard Plemper, James Snyder, Aiming Sun
Keywords(s): Assay, Microbiology/Infectious Diseases, Rare/Orphan Diseases
Category(s): TechPub Algolia > Therapeutics, TechPub Algolia > Drug Discovery, TechPub Algolia > Research Tools
Novel Inhibitors of NOX2/ROS
Applications Novel therapeutics for treatment of various inflammatory airway conditions including chronic obstructive pulmonary disease (COPD). Key Benefits NOX2/ROS inhibitors have potential for use in a wide variety of clinical indications. Current treatments are weakly effective or provide only symptomatic relief for inflammatory airway diseases. Technical...
Published: 7/30/2024   |   Inventor(s): Thota Ganesh, John David Lambeth, Susan Smith, Aiming Sun
Keywords(s): Cardiovascular, Immunology/Inflammation, Metabolic Diseases, Neuroscience/Pain, Respiratory, Small Molecule
Category(s): TechPub Algolia > Drug Discovery, TechPub Algolia > Therapeutics
Small Molecule Non-Nucleoside Inhibitors of the Measles Viruses
Application Small molecule measles virus RNA Dependent RNA Polymerase (RDRP) inhibitors. Key Benefits Potent (nM) non-nucleoside small molecule inhibitors of the measles virus RDRP protein. No current drug therapy for measles. Market Summary The target market for this therapeutic agent is in the developing world where measles has been known...
Published: 11/20/2024   |   Inventor(s): Richard Plemper, James Snyder, Aiming Sun, John Maina Ndungu, Jeong-Joong Yoon
Keywords(s): Microbiology/Infectious Diseases, Small Molecule
Category(s): TechPub Algolia > Therapeutics
Small Molecule Inhibitors Show Promise with RNA Viruses
Application Potent small molecule inhibitors of RNA viruses that cause many highly contagious and dangerous diseases such as canine distemper, RSV, influenza, and measles. Key Benefits Inhibits measles, canine distemper, human parainfluenza, and influenza A viruses. May be used for the management of a disease and for rapid control of possible...
Published: 11/20/2024   |   Inventor(s): Richard Plemper, James Snyder, Aiming Sun, John Maina Ndungu, Jeong-Joong Yoon
Keywords(s): Microbiology/Infectious Diseases, Small Molecule
Category(s): TechPub Algolia > Therapeutics