Search Results - james+snyder

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PI3Kα Inhibitors for the Treatment of Cancer
Application Compounds that inhibit the kinase activity of phospoinostidie 3-kinase (PI3Kα) for the treatment of cancer. Key Benefits Potential therapeutic targeted to pathway without a clinically approved inhibitor. Provides a useful pharmacological probe for research purposes. Market Summary In order to grow, cancer cells must have the...
Published: 7/30/2024   |   Inventor(s): Qi Shi, Thomas Kaiser, Dennis Liotta, James Snyder, Zackery Dentmon, John Diraddo
Keywords(s): Oncology, Small Molecule
Category(s): TechPub Algolia > Therapeutics
Assay for Non-Nucleoside Inhibitors of the Measles and Nipah Viruses
Application A cell-based assay to screen for inhibitors of the measles virus (MV). Highly active compounds have been identified and analogs have been synthesized and evaluated. Key Benefits Potent (sub-nM range), non-peptidic, non-nucleosidic compounds. Robust, cell-based, high-throughput screening assay. Technical Summary Vaccination serves...
Published: 9/26/2024   |   Inventor(s): Richard Plemper, James Snyder, Aiming Sun
Keywords(s): Assay, Microbiology/Infectious Diseases, Rare/Orphan Diseases
Category(s): TechPub Algolia > Therapeutics, TechPub Algolia > Drug Discovery, TechPub Algolia > Research Tools
Multi-Target CCR5/CXCR4 Chemokine Compounds for the Treatment of HIV
Application Chemical compounds that bind to both CCR5 and CXCR4 chemokine GPCRs as therapeutics to block HIV entry and infection. Key Benefits Targets both chemokine receptors used for cell entry by HIV: CCR5 & CXCR4. Eliminates the requirement of a tropism pre-test used for drug administration of single chemokine agents. Does not interfere...
Published: 7/30/2024   |   Inventor(s): Bryan Cox, Lawrence (larry) Wilson, Anthony Prosser, James Snyder, Dennis Liotta
Keywords(s): Microbiology/Infectious Diseases, Small Molecule
Category(s): TechPub Algolia > Therapeutics
OSIRIS: An Information Management Application for Use in Drug Discovery and Development
Application A web-based information management application for data tracking and sharing during the discovery and development of new small molecule therapeutics. Key Benefits Can be used to register compounds and display information about chemical structures and calculations. Easily customizable and has a ticket system to allow administrators...
Published: 7/30/2024   |   Inventor(s): Serdar Kurtkaya, Iestyn Lewis, Michael Natchus, James Snyder
Keywords(s): Chemistry, Mobile Enabled
Category(s): TechPub Algolia > Drug Discovery, TechPub Algolia > Software
CXCR4 Antagonists in Treatment of Cancer
Application Nonpeptidic molecules that block the chemokine receptor, CXCR4, for treatment of proliferative disorders including inhibition of cancer metastasis. Key Benefits Modulate CXCR4 receptor activity by interfering with SDF-1 ligand binding. Inhibit migration of metastatic cancer cells by blocking chemokine receptor signaling. Show increased...
Published: 7/30/2024   |   Inventor(s): Dennis Liotta, James Snyder, Weiqiang Zhan
Keywords(s): Oncology, Small Molecule
Category(s): TechPub Algolia > Therapeutics
Small Molecule Non-Nucleoside Inhibitors of the Measles Viruses
Application Small molecule measles virus RNA Dependent RNA Polymerase (RDRP) inhibitors. Key Benefits Potent (nM) non-nucleoside small molecule inhibitors of the measles virus RDRP protein. No current drug therapy for measles. Market Summary The target market for this therapeutic agent is in the developing world where measles has been known...
Published: 9/26/2024   |   Inventor(s): Richard Plemper, James Snyder, Aiming Sun, John Maina Ndungu, Jeong-Joong Yoon
Keywords(s): Microbiology/Infectious Diseases, Small Molecule
Category(s): TechPub Algolia > Therapeutics
Small Molecule Inhibitors Show Promise with RNA Viruses
Application Potent small molecule inhibitors of RNA viruses that cause many highly contagious and dangerous diseases such as canine distemper, RSV, influenza, and measles. Key Benefits Inhibits measles, canine distemper, human parainfluenza, and influenza A viruses. May be used for the management of a disease and for rapid control of possible...
Published: 7/30/2024   |   Inventor(s): Richard Plemper, James Snyder, Aiming Sun, John Maina Ndungu, Jeong-Joong Yoon
Keywords(s): Microbiology/Infectious Diseases, Small Molecule
Category(s): TechPub Algolia > Therapeutics
Triptolide Analog as Potent Anti-Inflammatory Drug Candidate
Application Small molecule therapeutics for the treatment of inflammation and autoimmune disorders. Key Benefits Decreased toxicity compared to the natural product triptolide. Improved aqueous solubility compared to triptolide. Market Summary Inflammation is known to be a component in a wide range of disease states including arthritis, asthma,...
Published: 9/26/2024   |   Inventor(s): Hariharan Venkatesan, James Snyder, Dennis Liotta, Susheng Wang
Keywords(s): Immunology/Inflammation, Small Molecule
Category(s): TechPub Algolia > Therapeutics