Search Results - research+reagent

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A platform for mapping reactive cysteines within the immunopeptidome
NU 2024-044 INVENTORS Xiaoyu Zhang* Chenlu Zhang Chen Zhou SHORT DESCRIPTION This invention provides novel chemical probes for mapping reactive cysteine residues within the major histocompatibility complex class I (MHC-I) immunopeptidome. BACKGROUND The immune system's recognition of infected or malignant cells hinges on the presentation...
Published: 12/11/2025   |   Updated: 10/31/2025   |   Inventor(s):  
Keywords(s): Biomarker, Immunology, Research reagent, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
WR (Western Reserve) Strain of Vaccinia Virus with K151E Mutation in A34R Gene
Mutation in gene A34R can regulate the release of progeny virions from the surface of parental cells.
Published: 5/12/2025   |   Updated: 12/6/2022   |   Inventor(s): Rafael Blasco, Bernard Moss
Keywords(s): A34, AC4XXX, AC5XXX, ACXXXX, AXXXXX, Cell, DDXXXX, DISSOCIATION, DXXXXX, GCXXXX, GLYCOPROTEIN, MEMBRANE, Progeny, REGULATED, research, RESEARCH MATERIAL, research reagent, RESEARCH TOOL, RM, RXXXXX, vaccinia, viral, virus, WIXXXX, XEXXXX, XKXXXX
Category(s): Collaboration Sought > Licensing, Application > Vaccines, Application > Therapeutics, Application > Research Materials, TherapeuticArea > Infectious Disease
Immortalized Stria Vascularis Cell Line SV-k1
Available for nonexclusive licensing for research uses is the cell line, SV-k1, derived from the Organ of Corti. The line was developed from the stria vascularis, an organ localized on the lateral wall of the cochlea, adjacent to the Organ of Corti, containing cell populations specialized in the production of an endolymph very rich in K+ characteristic...
Published: 10/28/2024   |   Updated: 12/6/2022   |   Inventor(s): Federico Kalinec, Gilda Canseco De Kalinec
Keywords(s): ID1XXX, IDXXXX, immortalized, RESEARCH MATERIAL, research reagent, RESEARCH TOOL, Stria, SV-k1, Vascularis, VPXXXX, WIXXXX
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Ophthalmology, Application > Research Materials, TherapeuticArea > Oncology, TherapeuticArea > Cardiology, TherapeuticArea > Infectious Disease, TherapeuticArea > Endocrinology, TherapeuticArea > Dental
Photocontrolled Dynamic Covalent Linkers for Polymer Networks
NU 2018-066 INVENTORS Julia Kalow* Joseph Accardo Boyeong Kang SHORT DESCRIPTION Dynamic crosslinkers that offer reversible stiffening and softening of polymer networks by a photoswitch BACKGROUND Polymer networks can be linked by weak, reversible physical interactions or strong but irreversible covalent bonds. Dynamic covalent bonds...
Published: 11/6/2025   |   Updated: 6/12/2019   |   Inventor(s):  
Keywords(s): Drug delivery, Materials, Polymer, Research reagent
Category(s): Physical Sciences > Materials and Industrial Processes
A Novel Class of Zinc-Chelating Ratiometric Fluorescent Probes
NU 2003-054 Inventors Masayasu Taki Thomas O'Halloran* AbstractNorthwestern scientists have synthesized a new class of zinc-chelating probes that are useful as ratiometric probes for zinc (Zn(II)). These reagents incorporate 2-(2'-hydroxypheny) benzooxazole (HBO) as a fluorophore with an aminomethyl pyridine moiety, to bind heavy metal ions selectively....
Published: 11/6/2025   |   Updated: 3/22/2019   |   Inventor(s):  
Keywords(s): Diagnostics, Research reagent, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Ultrasensitive Fluorescent Biosensors for Zinc
NU 2012-160 InventorsEmily Que Theresa Woodruff* Thomas O'Halloran* Short DescriptionNovel chemical sensor for zinc that can be used to monitor this ion in cells and the extracellular environment AbstractResearchers from Northwestern University have developed a new class of fluorescent zinc sensors, called ZincBYs, which can detect nanomolar concentrations...
Published: 11/6/2025   |   Updated: 3/12/2019   |   Inventor(s):  
Keywords(s): Research reagent, Research tool, Sensors
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
A Mouse Model to Visualize Motor Neurons
NU 2012-053 Inventor Pembe Hande Ozlinder AbstractNorthwestern researchers have developed a novel mice model that enables the visualization of both corticospinal and spinal motor neurons. In addition to enabling the in vivo visualization of these neurons at different stages of motor neuron disorders, this method also provides the capability to isolate...
Published: 3/18/2026   |   Updated: 3/12/2019   |   Inventor(s):  
Keywords(s): Animal Model, Cell Line, Drug discovery, Neurology, Research reagent
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Nanoparticle-Based Reagent for DNA and mRNA Detection
NU 2014-071 InventorsChad Mirkin* Chad Shade Robert Kennedy Short DescriptionNovel, highly sensitive reagent for detection of double stranded DNA in living cells AbstractNorthwestern scientists have developed a new reagent for detection of double stranded DNA in cells based on the well-known ruthenium DNA intercalator. Detection of specific genetic...
Published: 11/6/2025   |   Updated: 3/1/2019   |   Inventor(s):  
Keywords(s): Devices, Health IT, Medical device, Nanoparticle, Research reagent
Category(s): Life Sciences > Healthcare Devices, Tools & IT
Non-Toxic Probe for Cell Staining
NU 2014-010 InventorsMing Zhao* Songwang Hou Short DescriptionNovel non-toxic reagent for specifically detecting a cell membrane component AbstractNorthwestern University researchers have developed a new reagent for specifically staining phosphatidylethanolamine (PE) in cell membranes. PE is a major phospholipid found in cellular membranes, but it is...
Published: 11/6/2025   |   Updated: 3/1/2019   |   Inventor(s):  
Keywords(s): Biomedical, Materials, Research reagent, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Novel Cross-Linkers that Stabilize E3 Ubiquitin Ligase and Substrate Pairs
NU 2012-088InventorsNeil KelleherSungjin ParkIoanna NtaiPaul ThomasAlexander Statsuk* Short DescriptionNovel cross-linkers that stabilize E3 ubiquitin ligase-substrate complexesAbstractNorthwestern researchers have identified small molecule cross-linkers that are designed to stabilize the interaction between HECT-E3 ubiquitin ligases and their downstream...
Published: 11/6/2025   |   Updated: 2/22/2019   |   Inventor(s):  
Keywords(s): Cancer/Oncology, Diagnostics, Neurodegenerative disease, Research reagent, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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