Search Results - cell+line

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Repurposing a Potent MDM2 Inhibitor for Leukemia Treatment
Application VERU-111, also known as sabizabulin, is a potent microtubule inhibitor and, notably, an MDM2 inhibitor. This repurposed compound demonstrates remarkable efficacy in the treatment of Acute Myeloid Leukemia (AML). Key Benefits Unique dual-action functionality as a microtubule and MDM2 inhibitor. Successful inhibition of MDM2, an oncogene...
Published: 12/4/2024   |   Inventor(s): Deborah DeRyckere, Muxiang Zhou, Lu Bing Gu, Douglas Graham, Tao Liu
Keywords(s): Cell Line, Hematology/Blood Products, Oncology, Repurposed Drug
Category(s): TechPub Algolia > Drug Discovery
Assay to Screen Anti-metastatic Drugs
Abstract: Scientists at the NCI developed a research tool, a murine cell line model (JygMC(A)) with a reporter construct, of spontaneous metastatic mammary carcinoma that resembles the human breast cancer metastatic process in a triple negative mammary tumor. The assay is useful for screening compounds that specifically inhibit pathways involved in...
Published: 12/6/2024   |   Inventor(s): Nadia Castro, David Salomon, Frank Cuttitta
Keywords(s): ANGIOGENESIS, Cell line, Metastasis, Triple Negative Breast Cancer, tumorigenesis
Category(s): TherapeuticArea > Oncology, Collaboration Sought > Licensing, Application > Research Materials
Target for Anti-Tumor Immune Responses
Abstract: The Surgery Branch of the National Cancer Institute is seeking statements of capability or interest from parties interested in collaborative research to carry out genotypic as well as phenotypic analysis of the 888 mel cell line in order to better understand the nature of tumor cells that respond to therapy. In addition, this cell line can...
Published: 4/8/2024   |   Inventor(s): Steven Rosenberg, Suzanne Topalian
Keywords(s): 888-mel, CANCER, Cell line, MELANOMA
Category(s): Application > Research Materials, TherapeuticArea > Oncology, Collaboration Sought > Licensing
Reporter Assay for Detection and Quantitation of Replication-Competent Gammaretrovirus
Abstract: Gammaretroviral vectors were the first viral gene-therapy vectors to enter clinical trials and remain in use. One potential hazard associated with the use of such vectors is the presence of replication-competent retroviruses (RCR) in the vector preparations – either as a result of: 1) recombination events between the plasmids used for...
Published: 4/8/2024   |   Inventor(s): Alan Rein, Amanda (Declined Royalty) Aloia
Keywords(s): Cell line, Gammaretrovirus, Gaussia Luciferase, GENE THERAPY, PLASMID, RCR, Rein, Replication-Competent Retrovirus, Vector Preparation
Category(s): Application > Research Materials, Collaboration Sought > Licensing, TherapeuticArea > Immunology
Adriamycin-Resistant Ovarian Tumor Cell Line, NCI/ADR-RES
Abstract: Cancer cells may acquire drug resistance after prolonged chemotherapy. In many cases, cancer cells develop resistance to several drugs with distinct structures and modes of action. This multi-drug resistance phenomenon increases the complexity of cancer treatment. Researchers at the National Cancer Institute (NCI) have derived an Adriamycin-resistant...
Published: 4/8/2024   |   Inventor(s): Kenneth Cowan
Keywords(s): ADENOCARCINOMA, Adriamycin-resistant, Cell line, Cowan, MCF-7/ADR-RES, MDR1, Multi-Drug Resistance, NCI/ADR-RES, OVARIAN CANCER, OVCAR-8, P-GLYCOPROTEIN
Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Oncology
Tni-FNL: An Improved Trichoplusia Ni Cell Line for Protein Expression
Abstract: Researchers at the National Cancer Institute (NCI) have developed an improved insect cell line, Tni-FNL, derived from the cabbage looper, Trichoplusia ni.  The Tni-FNL cell line is capable of high level expression of heterologous proteins using baculovirus-based expression systems.  When compared to commercially available cell lines used for...
Published: 5/22/2024   |   Inventor(s): Dominic Esposito, Ralph (Butch) Hopkins, Veronica Roberts
Keywords(s): Baculovirus, Cell line, Esposito, Insect Cell, Protein Expression, Tni-FNL
Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Oncology
Stem Cell Factor-responsive FcepsilonRI Bearing Human Mast Cell Line LAD2
A human mast cell line LAD2 that more closely resembles normal in vivo and in vitro human mast cells by expressing functional FcepsilonRI receptors and responding to stem cell factor (SCF) with proliferation, as described in Leuk Res. 2003 Aug;27(8):677-82 and developed by the laboratory of Dr. Dean Metcalfe at the National Institute of Allergy and...
Published: 10/28/2024   |   Inventor(s): Arnold Kirshenbaum, Cem Akin, Dean Metcalfe
Keywords(s): Cell line, IA3XXX, IAXXXX, IDXXXX, IXXXXX, Mast cell disease, Mastocytosis, RM, WIXXXX
Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Therapeutics, TherapeuticArea > Immunology
Caspase-3 Deficient MEFs with Mutant Caspase-3 Re-Introduced
Application Mouse embryonic fibroblast (MEF) line deficient in caspase-3 that are reconstituted with constitutively expressed mutant versions of the protease. Key Benefits An immortalized caspase-3-deficient MEF cell line. Tool to study protease induced apoptosis. Technical Summary Emory inventors have discriminated a previously unknown role...
Published: 9/26/2024   |   Inventor(s): Lawrence Boise, Katelyn Ponder
Keywords(s): Cell Line, Enzyme/Protein
Category(s): TechPub Algolia > Research Tools
Non-Human Primate Model for Urinary Bladder Regeneration
NU 2010-150InventorsEarl Cheng*Natalie FullerDerek MatokaArun SharmaMatthew BuryAndrew MarksAbstractNorthwestern researchers have developed a model for bladder regeneration using bone marrow stem and progenitor cells (BMSPCs). BMSPCs are non-exclusively comprised of mesenchymal stem cells (MSCs), endothelial progenitor cells (EPCs), and hematopoietic...
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Cell Line, Research tool, Stem cell, Therapeutics
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
A Mouse Model to Visualize Motor Neurons
NU 2012-053 Inventor Pembe Hande Ozlinder AbstractNorthwestern researchers have developed a novel mice model that enables the visualization of both corticospinal and spinal motor neurons. In addition to enabling the in vivo visualization of these neurons at different stages of motor neuron disorders, this method also provides the capability to isolate...
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Animal Model, Cell Line, Research reagent
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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