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Assay to Screen Anti-metastatic Drugs
Abstract:
Scientists at the NCI developed a research tool, a murine cell line model (JygMC(A)) with a reporter construct, of spontaneous metastatic mammary carcinoma that resembles the human breast cancer metastatic process in a triple negative mammary tumor. The assay is useful for screening compounds that specifically inhibit pathways involved in...
Published: 12/6/2024
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Inventor(s): Nadia Castro, David Salomon, Frank Cuttitta
Keywords(s): ANGIOGENESIS, Cell line, Metastasis, Triple Negative Breast Cancer, tumorigenesis
Category(s): TherapeuticArea > Oncology, Collaboration Sought > Licensing, Application > Research Materials
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Target for Anti-Tumor Immune Responses
Abstract: The Surgery Branch of the National Cancer Institute is seeking statements of capability or interest from parties interested in collaborative research to carry out genotypic as well as phenotypic analysis of the 888 mel cell line in order to better understand the nature of tumor cells that respond to therapy. In addition, this cell line can...
Published: 4/8/2024
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Inventor(s): Steven Rosenberg, Suzanne Topalian
Keywords(s): 888-mel, CANCER, Cell line, MELANOMA
Category(s): Application > Research Materials, TherapeuticArea > Oncology, Collaboration Sought > Licensing
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Reporter Assay for Detection and Quantitation of Replication-Competent Gammaretrovirus
Abstract:
Gammaretroviral vectors were the first viral gene-therapy vectors to enter clinical trials and remain in use. One potential hazard associated with the use of such vectors is the presence of replication-competent retroviruses (RCR) in the vector preparations – either as a result of: 1) recombination events between the plasmids used for...
Published: 4/8/2024
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Inventor(s): Alan Rein, Amanda (Declined Royalty) Aloia
Keywords(s): Cell line, Gammaretrovirus, Gaussia Luciferase, GENE THERAPY, PLASMID, RCR, Rein, Replication-Competent Retrovirus, Vector Preparation
Category(s): Application > Research Materials, Collaboration Sought > Licensing, TherapeuticArea > Immunology
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Adriamycin-Resistant Ovarian Tumor Cell Line, NCI/ADR-RES
Abstract: Cancer cells may acquire drug resistance after prolonged chemotherapy. In many cases, cancer cells develop resistance to several drugs with distinct structures and modes of action. This multi-drug resistance phenomenon increases the complexity of cancer treatment.
Researchers at the National Cancer Institute (NCI) have derived an Adriamycin-resistant...
Published: 4/8/2024
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Inventor(s): Kenneth Cowan
Keywords(s): ADENOCARCINOMA, Adriamycin-resistant, Cell line, Cowan, MCF-7/ADR-RES, MDR1, Multi-Drug Resistance, NCI/ADR-RES, OVARIAN CANCER, OVCAR-8, P-GLYCOPROTEIN
Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Oncology
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Tni-FNL: An Improved Trichoplusia Ni Cell Line for Protein Expression
Abstract: Researchers at the National Cancer Institute (NCI) have developed an improved insect cell line, Tni-FNL, derived from the cabbage looper, Trichoplusia ni. The Tni-FNL cell line is capable of high level expression of heterologous proteins using baculovirus-based expression systems. When compared to commercially available cell lines used for...
Published: 5/22/2024
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Inventor(s): Dominic Esposito, Ralph (Butch) Hopkins, Veronica Roberts
Keywords(s): Baculovirus, Cell line, Esposito, Insect Cell, Protein Expression, Tni-FNL
Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Oncology
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Stem Cell Factor-responsive FcepsilonRI Bearing Human Mast Cell Line LAD2
A human mast cell line LAD2 that more closely resembles normal in vivo and in vitro human mast cells by expressing functional FcepsilonRI receptors and responding to stem cell factor (SCF) with proliferation, as described in Leuk Res. 2003 Aug;27(8):677-82 and developed by the laboratory of Dr. Dean Metcalfe at the National Institute of Allergy and...
Published: 10/28/2024
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Inventor(s): Arnold Kirshenbaum, Cem Akin, Dean Metcalfe
Keywords(s): Cell line, IA3XXX, IAXXXX, IDXXXX, IXXXXX, Mast cell disease, Mastocytosis, RM, WIXXXX
Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Therapeutics, TherapeuticArea > Immunology
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Non-Human Primate Model for Urinary Bladder Regeneration
NU 2010-150InventorsEarl Cheng*Natalie FullerDerek MatokaArun SharmaMatthew BuryAndrew MarksAbstractNorthwestern researchers have developed a model for bladder regeneration using bone marrow stem and progenitor cells (BMSPCs). BMSPCs are non-exclusively comprised of mesenchymal stem cells (MSCs), endothelial progenitor cells (EPCs), and hematopoietic...
Published: 4/4/2025
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Inventor(s):
Keywords(s): Cell Line, Research tool, Stem cell, Therapeutics
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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A Mouse Model to Visualize Motor Neurons
NU 2012-053 Inventor Pembe Hande Ozlinder AbstractNorthwestern researchers have developed a novel mice model that enables the visualization of both corticospinal and spinal motor neurons. In addition to enabling the in vivo visualization of these neurons at different stages of motor neuron disorders, this method also provides the capability to isolate...
Published: 7/3/2024
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Inventor(s):
Keywords(s): Animal Model, Cell Line, Research reagent
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Human Induced Pluripotent Stem Cells
ApplicationHuman induced pluripotent stem cells useful for human stem cell biology, Lesch-Nyhan disease or DYT1 dystonia.Technical SummaryLesch-Nyhan syndrome (juvenile gout) is a rare, inherited disorder caused by deficiency in hypoxanthine-guanine phosphoribosyltransferase (HGPRT). The disease causes overproduction of uric acid often leading to gout...
Published: 9/26/2024
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Inventor(s): Hyder Jinnah
Keywords(s): Cell Line, Genetic Disorders, Neuroscience/Pain
Category(s): TechPub Algolia > Research Tools
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CIITA Deficient Human B Cell Line
Application
Human B cell line deficient in class II transactivator (CIITA).
Key Benefits
Deficient in CIITA.
Useful for expression of tranfected MHC-II genes and alleles.
Technical Summary
The class II transactivator (CIITA) is essential for the expression of major histocompatibility complex class II (MHC-II) genes. However, the role of CIITA...
Published: 9/26/2024
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Inventor(s): Jeremy Boss, Christopher (Chris) Scharer
Keywords(s): Cell Line, Immunology/Inflammation
Category(s): TechPub Algolia > Research Tools
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