Search Results - microscopy

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Squeezed Light Field Microscopy (SLIM) (Case No. 2024-153)
Summary: UCLA researchers in the Department of Bioengineering have developed a computational imaging method that enables detection of 3D light signals using only a single camera sensor area for optimized surgical visualization. Background: Surgical procedures necessitate high precision imaging, especially when targeting specific anatomical structures....
Published: 8/5/2024   |   Inventor(s): Liang Gao, Zhaoqiang Wang, Ruixuan Zhao
Keywords(s): 3D tissue imaging, computational imaging, image-guided surgery, Imaging, Microscopy, Microscopy And Imaging, Neuroimaging
Category(s): Life Science Research Tools > Microscopy And Imaging, Medical Devices > Medical Imaging > Fluorescence
Universal Linear Intensity Transformations Using Spatially-Incoherent Diffractive Processors (Case No. 2023-192)
Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed a novel platform technology to facilitate the design of all-optical visual processors, which can be used to perform advanced computational tasks at the speed of light. Background: Information processing via light is a cutting-edge field among optics...
Published: 4/5/2024   |   Inventor(s): Aydogan Ozcan, MD Sadman Rahman, Xilin Yang
Keywords(s): Adaptive Optics, Algorithm Optical Coherence Tomography, all-optical diffractive computing, all-optical transformation, Artifical Intelligence (Machine Learning, Data Mining), Artificial Intelligence, Atomic Force Microscopy Optical Tweezers, computational imaging, deep diffractive network, Deep Learning, Deep learning-based sensing, diffractive processor, Dispersion (Optics), Electron Microscope, Electro-Optics, fluorescence microscopy, Focus (Optics), Infrared Electromagnetic Spectrum Dispersion (Optics), interference processor, large language model (LLNMs), linear optics, linear transformations, Machine Learning, Microscope, Microscopy, Microscopy And Imaging, Near-Field Scanning Optical Microscope, neural networks, Nonlinear Optics, non-linear optics, Optical Coherence , Optical Communication , Optical computing, Optical Fiber Copper Wire And Cable, optical implementation, Optical Microscope, Optical networks, optical processor, optical transmission, Optics Parabolic Reflector Curved Mirror, phase-only diffractive network, reverse engineered optical system, Software, Software & Algorithms, Software Development Tools, spatially-incoherent light, start to end optics design, Surgical Instrument Optical Coherence Tomography, three dimensional imaging, visual computing, Waferscale Processors
Category(s): Optics & Photonics, Optics & Photonics > Microscopy, Platforms, Software & Algorithms > Image Processing, Electrical, Electrical > Signal Processing, Electrical > Computing Hardware
Label-Free Optical Mapping for Large-Area Biomechanical Dynamics of Multicellular Systems (Case No. 2023-290)
Summary: UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a novel label-free optical mapping method for profiling real-time biomechanical dynamics over larger areas with high spatiotemporal resolution. Background: Mapping biomechanical dynamics often involves the use of various advanced technologies to measure...
Published: 6/27/2024   |   Inventor(s): Pei Yu Chiou, Yen-Ju Lin
Keywords(s): bioimaging, Biomechanics, cell imaging, Confocal Microscopy, dye, Fluorescence Microscope, labeling, Microscopy, Microscopy And Imaging, resolution, traction force microscopy
Category(s): Life Science Research Tools, Life Science Research Tools > Microscopy And Imaging, Life Science Research Tools > Cell Counting And Imaging, Medical Devices, Medical Devices > Medical Imaging, Platforms, Platforms > Diagnostic Platform Technologies
Mitotic Figures Electronic Counting Application for Surgical Pathology
Abstract: Cancer diagnosis depends on the assessment of patient biopsies to determine tumor type, grading, and stage of malignancy. Pathologists visually review specimens and count mitotic figures (MF) in a variety of cancer types to help gauge aggressiveness, guide treatment, and inform patient prognosis. Current technology for recording MF counts...
Published: 5/23/2024   |   Inventor(s): Robert Simpson, Munish Puri, Stephen Hewitt
Keywords(s): cell proliferation, COUNTING, ELECTRONIC, MATLAB, Matrix Laboratory, MF, MICROSCOPY, Mitotic Figures, PATHOLOGY, Simpson, SURGICAL
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Software / Apps, TherapeuticArea > Oncology
A New Class of Stable Heptamethine Cyanine Fluorophores and Biomedical Applications Thereof
Abstract: Heptamethine cyanines are among the most widely used near-IR fluorophores. The near-IR range (between about 650 nm and 900 nm) is very useful for imaging applications due to the absence of background autofluorescence. Despite extensive use, many of these fluorophores suffer from chemical instability. Specifically, most of the current and commonly...
Published: 4/8/2024   |   Inventor(s): Martin Schnermann, Roger Nani, James Shaum
Keywords(s): Antibody labeling, DYE, Fluorescence-activated cell sorting (FACS), Fluorophore, Heptamethine Cyanines, IMAGING, Imaging Microscopy, Imaging reagent, MICROSCOPY, near-IR fluorophores, Optical-Guided Surgery
Category(s): TherapeuticArea > Oncology, Collaboration Sought > Licensing, Application > Research Materials, Collaboration Sought > Collaboration
Polymer-Cast Inserts for Cell Histology and Microscopy
Abstract: Three-dimensional (3D) cell cultures systems are important for studying cell biology because they provide in vivo-like microenvironments more physiologically relevant than two-dimensional (2D) culture systems. In 3D culture systems, cells are grown in culture matrixes and turn into spheroids and organoids later processed for downstream analysis...
Published: 4/8/2024   |   Inventor(s): Ralph Parchment, Thu Nguyen
Keywords(s): 3D Cell Culture, high-throughput screening, Histology, Histopathology, MICROSCOPY, Organoids, Parchment, Polymer-cast, Spheroids
Category(s): TherapeuticArea > Dermatology, TherapeuticArea > Immunology, TherapeuticArea > Infectious Disease, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Research Materials
Enhanced Tissue Clearing Solution, Clearing-Enhanced 3D (Ce3D), Compatible with Advanced Fluorescence Microscopy Imaging
NIH immunologists have created a solution, Clearing-enhanced 3D (Ce3D), that can be used to make entire organs extremely transparent (top right panel). This allows the tissue to be imaged using advanced fluorescence microscopy techniques (bottom panel). Unlike current tissue clearing solutions, the Ce3D tissue clearing solution is robustly compatible...
Published: 7/25/2024   |   Inventor(s): Michael Gerner, Weizhe Li, Ronald Germain
Keywords(s): 3D, AA3AXX, Ce3D:, Cellular, Clearing, Epitope, Fluorescence, histo-cytometry, IMAGING, imaging agent, Method, MICROSCOPY, REPORTER, Tissue
Category(s): Collaboration Sought > Collaboration
Microscopy System for Distinguishing Stimulated Emissions as a Means of Increasing Signal
The invention pertains to a system and method for distinguishing stimulated emissions as a means of enhancing signal strength of fluorescent markers in fluorescence microscopy applications. The system is arranged such that an excitation beam (e.g., laser beam) illuminates a sample along some axis exciting the fluorescent markers used in the sample....
Published: 7/25/2024   |   Inventor(s): Sanjay Varma, Andrew York
Keywords(s): AC1XXX, AC3XXX, AC4XXX, Distinguishing, Emission, Fluorescence, Increasing, MEANS, MICROSCOPY, Signal, STIMULATED, WMXXXX, XDXXXX, XFXXXX, XGXXXX, YAXXXX, YFXXXX
Category(s): Collaboration Sought > Collaboration, Application > Medical Devices, Application > Software / Apps, Application > Research Materials, Application > Diagnostics, Application > Non-Medical Devices, Application > Therapeutics, Application > Consumer Products
Resolution Enhancement for Line-Scanning Excitation Microscopy
The invention describes a method for improving the spatial resolution of optical microscopes that use line-scanning excitation, such as line-scanning confocal microscopes, line-scanning STED microscopes, or line-scanning light-sheet microscopes. Common elements of the invention include: a) an apparatus for exciting and scanning a line-like excitation...
Published: 7/25/2024   |   Inventor(s): Andrew York, John Giannini, Abhishek Kumar, Hari Shroff
Keywords(s): AC1XXX, AC2XXX, AC3XXX, fluorescent, MICROSCOPE, MICROSCOPY, RESOLUTION, XDXXXX, XFXXXX, YFXXXX
Category(s): Collaboration Sought > Collaboration, Application > Software / Apps, Application > Non-Medical Devices, Application > Medical Devices, Application > Diagnostics
Resolution Enhancement for Light Sheet Microscopy Systems
The invention pertains to a technique for enhancing the resolution of images in light sheet microscopy by adding additional enhanced depth-of-focus optical arrangements and high numerical aperture objective lenses. The technique employs an arrangement of three objective lenses and a processor for combining captured images. The image composition utilizes...
Published: 7/25/2024   |   Inventor(s): Yicong Wu, Sara Abrahamsson, Hari Shroff
Keywords(s): AA2XXX, AC1XXX, AC3XXX, ADXXXX, Light-emitting, Light-scattering, MICROSCOPY, VPXXXX, WIXXXX, XFXXXX, YBXXXX
Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Medical Devices, Application > Research Materials, Application > Software / Apps, TherapeuticArea > Cardiology, TherapeuticArea > Dental, TherapeuticArea > Endocrinology, TherapeuticArea > Ophthalmology, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, Application > Non-Medical Devices
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