Search Results - shanthi+srinivasan

3 Results Sort By:
Growth Factor as a Treatment for Obesity
Applications Therapeutic use of Glial Cell Line-Derived Neurotrophic Factor (GDNF) to treat obesity. Potential drug target for further therapeutic development. Key Benefits Growth Factor expression in the brain causes a reduction in high fat diet-induced obesity. Fat level reduction has been shown in both mouse and human cells. Reducing...
Published: 12/4/2024   |   Inventor(s): Shanthi Srinivasan
Keywords(s): Metabolic Diseases
Category(s): TechPub Algolia > Drug Discovery, TechPub Algolia > Therapeutics
Mouse Enteric Neuronal Cell Line
Application Fetal and postnatal enteric neuronal cell lines for use in studying the enteric nervous system. Technical Summary We have developed fetal (IM-FEN) and postnatal (IM-PEN) enteric neuronal cell lines with features similar to primary enteric neurons. The IM-FEN and IM-PEN have been passaged 40 times since their isolation and have shown no...
Published: 10/3/2025   |   Inventor(s): Shanthi Srinivasan
Keywords(s): Cell Lines and Organoids, Neurology and Pain Treatments
Category(s): TechPub Algolia > Research Tools
Neurotrophic Factor as Therapeutic for Diabetes
Application The use of Glial Cell-derived Neurotrophic Factor (GDNF) or its mimics as a potential therapeutic for diabetes mellitus type 1 (IDDM). Key Benefits GDNF enhances pancreatic β-cell growth and survival in vitro and in vivo. GDNF transgenic mice have lower blood glucose levels and are more resistant to developing diabetes compared...
Published: 7/22/2025   |   Inventor(s): Shanthi Srinivasan
Keywords(s): Metabolic Disease Treatments
Category(s): TechPub Algolia > Therapeutics