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Enhancing CAR Macrophage Efferocytosis via Surface Engineered Lipid Nanoparticles Targeting LXR Signaling

CAR-Macrophage efficiently uptakes apoptotic cell and cholesterol crystals via β-cyclodextrin, activating the LXR pathway and promoting cholesterol efflux Invention Summary: Atherosclerosis is considered the major cause of cardiovascular disease, leading to ischemic heart disease and ischemic strokes, the 1st and 5th largest causes of...

Published: 9/20/2024 | Inventor(s): Skylar Chuang, Ki-Bum Lee

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Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Nanotechnology

Neural repair through inhibition of Reg3A signaling

Reference #: 1677 The University of South Carolina is offering licensing opportunities for Neural repair through inhibition of Reg3A signaling. Background: Human peripheral nerve regeneration is rarely successful when the nerve's axons must regrow more than 5-6 cm. By the time the regenerating axons in the nerve get past 5-6 cm, the environment...

Published: 9/18/2024 | Inventor(s): Jeffery Twiss, Courtney Buchanan, Jinyoung Lee, Lauren Vaughn, Ashley Kalinski

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Category(s): Biomedical and Life Sciences, Health Sciences

Intro Sentence: UCLA researchers from the Department of Computational Medicine have developed a novel model for tabulating electronic health records. Background: Electronic Health Records (EHR) provide healthcare systems with insights into health histories. Machine learning models have been developed to use EHR for inference tasks based on specific...

Published: 9/6/2024 | Inventor(s): Jeffrey Chiang, Simon Lee

Keywords(s): Artifical Intelligence (Machine Learning, Data Mining), clinical decision support, EHR, EHR integration, electronic health records (EHR), Hospital Systems And Devices, lab results analysis, large language model (LLNMs), Machine Learning, machine learning modeling, patient questionnaire, personalized medicine, predictive analytics, specialist referral

Category(s): Software & Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Data Analytics, Software & Algorithms > Programs, Medical Devices, Medical Devices > Hospital Systems

LARGE-SCALE WIRELESS BIOSENSOR NETWORKS FOR BIOMEDICAL DIAGNOSTICS

Overview Electronic sensors are increasingly prevalent in the world around us. Scalability, however, is complicated by the fact that the signals at each sensor location can vary both in time and in magnitude, but often must be read at once by a single transceiver. Current brain-computer interface research, as an example, is hampered by inefficiencies...

Published: 8/22/2024 | Inventor(s): Arto Nurmikko, Jihun Lee, Farah Laiwalla

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Category(s): Diagnostics

Bionic color structures as eco-friendly food dyes

This technology creates eco-friendly, food-safe colorants by forming edible photonic nanostructures from natural colorants in water. Using microfluidic devices and controlled thermal processes, it enhances color stability and brightness, providing a safer alternative to synthetic additives. https://nu.technologypublisher.com/files/sites/thumbnail.jpeg ...

Published: 9/10/2024 | Inventor(s): Leila Deravi, Wei-Ting Chang, Ji-Young Lee

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Category(s): Technology Classifications > 1. Life Science > Biotechnology, Technology Classifications > 2. Physical Science > Advanced materials/Nanomaterials, Technology Classifications > 1. Life Science > Green Chemistry

Photoactivated Selective Release (PHASR) of Droplets from Microwell Arrays

A photoresponsive polymer layer that can be integrated into microfluidic devices for selective release of unique droplets Problem: Droplet microfluidics are used for single molecule detection and analysis, such as isolation of protein biomarkers for monitoring of disease progression. Current techniques for recovering unique molecules or cells from droplet...

Published: 8/2/2024 | Inventor(s): Daeyeon Lee, Junhyong Kim, Yongwon Choi, Syung-Hun Han

Keywords(s): Artificial Intelligence (AI) & Machine Learning, Microfluidics, Nanotechnology

Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Research Tools & Reagents

Single-Step Wettability Patterning for Microfluidic Generation of Emulsions

Method to transfer wettability properties of a mold to microfluidic devices, defining hydrophobic/hydrophilic regions through variable perfluoropolyether concentration. Problem: Current wettability patterning methods involve sequentially flowing chemicals into channels, blocking areas where treatment is not desired. These multi-step methods are labor...

Published: 7/23/2024 | Inventor(s): Daeyeon Lee, David Issadore, Jingyu Wu

Keywords(s): Microfluidics

Category(s): Technology Classifications > Chemical Processes and Synthesis

Effective Anti-Fouling Surface Coating of Microfluidic Mixing Devices for Robust mRNA Lipid Nanoparticles (LNP) Manufacturing

Employment of omniphobic, thin-layer perfluorocarbon (TLP) coating to prevent fouling and clogging in microfluidic mixing devices during mRNA LNP formulations. Problem: Lipid nanoparticle (LNP)-based delivery systems for mRNA and other therapeutics recently gained popularity because of their application in the Pfizer/BioNTech and Moderna COVID-19 vaccines....

Published: 7/15/2024 | Inventor(s): Daeyeon Lee, Yoon-Ho Hwang, David Issadore

Keywords(s): Bioengineering, Microfluidics

Category(s): Technology Classifications > Hardware & Components, Technology Classifications > Materials

Poly(Tetramethylene Oxide)-Based Segmented Ionenes Block Copolymer with Aliphatic or DABCO Hard Segments

Background Ionenes contain charges in their polymer backbones, as opposed to traditional ionomers that have charges on the pendant site of the backbone. Ionenes, whether positive or negative, typically fall into two categories- either segmented or non-segmented. Segmented ionenes contain alternating hard and soft segments along the polymer backbone,...

Published: 7/1/2024 | Inventor(s): Matthew Green, Jae Sang Lee

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Category(s): Physical Science, Advanced Materials/Nanotechnology, Applied Technologies

A drug delivery system tuned to the endogenous mechanical environment

Technology Overview: Tissues within the body experience mechanical perturbations across multiple force magnitudes and length scales, from mechanotransduction at the cell level to the dynamics of load-bearing joints. These forces not only maintain tissue homeostasis, but can also initiate degenerative processes when applied at supra-physiologic levels....

Published: 6/21/2024 | Inventor(s): Robert Mauck, George Dodge, Daeyeon Lee

Keywords(s): Drug Delivery

Category(s): Technology Classifications > Therapeutics

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