Search Results - diagnostic+assays%2fdevices

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Microfluidic Digital Nanobiosensor for Point-of-Care Detection of NT-proBNP
Heart failure is a serious global burden affecting more than 64 million people worldwide. It has high morbidity and mortality and poor quality of life, making it a major public health priority. N-terminal proBNP (NT-pro-BNP) is a well-established clinical biomarker for monitoring and managing heart failure. Regular and frequent monitoring of patients...
Published: 9/3/2024   |   Inventor(s): Shaopeng Wang, Chao Chen
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors, Medical Devices
Breath-Based Diagnostics for Lower Respiratory Infections
Acute pulmonary infections, or pneumonia, are a leading cause of infectious death worldwide with more than 2.3 million deaths each year. Existing strategies for diagnosing pneumonia are based on clinical, radiological and microbial criteria, which is time-consuming, low accuracy, and subject to interobserver variability. Furthermore, obtaining a lower...
Published: 9/3/2024   |   Inventor(s): Heather Bean, Emily Higgins Keppler
Keywords(s):  
Category(s): Bioanalytical Assays, Chemistries & Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors, Diagnostic Assays/Devices
Anti-Galectin-1 Monoclonal Antibody
Galectin-1 (Gal-1) is a ubiquitously expressed galactoside-binding 14-kDa lectin that is differentially expressed by a variety of pathological as well as normal cell types. Extracellular Gal-1 has been shown to exert strong Immunomodulatory activity and has been implicated in numerous cancer and autoimmune diseases. Further, recent research has shown...
Published: 7/2/2024   |   Inventor(s): Douglas Lake, Kirsten Pfeffer, Thai Ho
Keywords(s):  
Category(s): Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Cancer, Diagnostic Assays/Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors
Tandem Antigen Capture ELISAs for Measuring Short and Long Isoforms of QSOX1
Quiescin sulfhydryl oxidase1 (QSOX1) is a sulfhydryl oxidase that is overexpressed in several malignancies and as such is a potential biomarker for multiple cancer types as well as acute decompensated heart failure (ADHF). Since its discovery, QSOX1 has been identified as a key player in the facilitation of tumor cell migration, creating a significant...
Published: 5/31/2024   |   Inventor(s): Douglas Lake, Thai Ho, Calvin Koelbel
Keywords(s):  
Category(s): Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Cancer, Diagnostic Assays/Devices, Medical Diagnostics/Sensors, Life Science (All LS Techs)
DNA Sequencing and Mutation Rate Estimation
DNA mutations are the basis of all heritable biological variation. Some variation gives rise to beneficial traits, many are neutral or nearly neutral, and some result in deleterious phenotypes. While it is commonly believed that DNA mutations affect evolutionary phenotypic trajectories over millions of years, scientific advances have shown that this...
Published: 5/7/2024   |   Inventor(s): Stephan Baehr, Jean-Francoi Gout, Michael Lynch
Keywords(s):  
Category(s): Applied Technologies, Computing & Information Technology, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Genomic Assays/Reagents/Tools, Life Science (All LS Techs)
Diagnostic and Prognostic Biomarkers for ALS
Amyotrophic Lateral Sclerosis (ALS) is a terminal neurodegenerative disease defined by the progressive loss of motor neuron function. Despite intense research efforts, clinical outcomes in ALS patients have remained limited. Because there are no diagnostic or prognostic biomarkers for ALS, patients are classified based on the site of symptom onset,...
Published: 4/18/2024   |   Inventor(s): Jarrett Eshima, Barbara Smith, Chris Plaisier
Keywords(s):  
Category(s): Diagnostic Assays/Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors, Neurodegenerative Disease Technologies
DNA Methylation Barriers
In normal differentiated cells, most of the genome is densely methylated, except CpG islands near promoters of actively transcribed genes. Maintaining this boundary between unmethylated promoter-associated and adjacent methylated regions is crucial as loss of segregation can lead to disease. Unfortunately, it is not clear where these boundaries are,...
Published: 6/5/2024   |   Inventor(s): Li Liu, Jingmin Shu
Keywords(s):  
Category(s): Applied Technologies, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Diagnostic Assays/Devices
System to Rapidly Screen and Detect Small Molecules
The analysis of small-molecule metabolites and drugs in body fluids and tissue extracts plays a vital role in human health, food safety and environmental monitoring. The current gold standard for small molecule detection is mass spectrometry, which is expensive, time consuming, and requires trained personnel. Universal point-of-care (POC) testing would...
Published: 2/27/2024   |   Inventor(s): Chao Wang, MD Ashif Ikbal
Keywords(s):  
Category(s): Bioanalytical Assays, Chemistries & Devices, Chemical/Biological Sensors, Life Science (All LS Techs), Diagnostic Assays/Devices
Tests for Diagnosis or Prognostic Monitoring of Valley Fever
Valley Fever (VF), or coccidioidomycosis, is a systemic fungal infection caused by the fungus Coccidioides that is endemic to the Southwestern United States but can occur in other regions of the world. Roughly 40% of VF patients experience vague or flu-like symptoms and approximately 5-10% of patients, progress to a disseminated form of the disease...
Published: 1/4/2024   |   Inventor(s): Mitch Magee, Douglas Lake
Keywords(s):  
Category(s): Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors, Proteomic Assays/Reagents/Tools
Method for Measuring Human Vision Cortical Magnification Factor
In human vision, varying amounts of neural resources are devoted to visual fields. Retinotopic mapping uses fMRI to give a projection of the visual field and its cortical representation in a subject. Cortical magnification factor (CMF) is a common measure of the ratio of the cortical areas devoted to each region of the visual field, to show visual acuity...
Published: 1/9/2024   |   Inventor(s): Yujian Xiong, Zhong-Lin Lu, Yalin Wang
Keywords(s):  
Category(s): Applied Technologies, Computing & Information Technology, Diagnostic Assays/Devices, Imaging, Life Science (All LS Techs), Medical Imaging
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