Search Results - douglas+lake

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Galectin-1 (Gal-1) is a ubiquitously expressed galactoside-binding 14-kDa lectin that is differentially expressed by a variety of pathological as well as normal cell types. Extracellular Gal-1 has been shown to exert strong Immunomodulatory activity and has been implicated in numerous cancer and autoimmune diseases. Further, recent research has shown...

Published: 7/2/2024 | Inventor(s): Douglas Lake, Kirsten Pfeffer, Thai Ho

Keywords(s):

Category(s): Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Cancer, Diagnostic Assays/Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors

Tandem Antigen Capture ELISAs for Measuring Short and Long Isoforms of QSOX1

Quiescin sulfhydryl oxidase1 (QSOX1) is a sulfhydryl oxidase that is overexpressed in several malignancies and as such is a potential biomarker for multiple cancer types as well as acute decompensated heart failure (ADHF). Since its discovery, QSOX1 has been identified as a key player in the facilitation of tumor cell migration, creating a significant...

Published: 5/31/2024 | Inventor(s): Douglas Lake, Thai Ho, Calvin Koelbel

Keywords(s):

Category(s): Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Cancer, Diagnostic Assays/Devices, Medical Diagnostics/Sensors, Life Science (All LS Techs)

Tests for Diagnosis or Prognostic Monitoring of Valley Fever

Valley Fever (VF), or coccidioidomycosis, is a systemic fungal infection caused by the fungus Coccidioides that is endemic to the Southwestern United States but can occur in other regions of the world. Roughly 40% of VF patients experience vague or flu-like symptoms and approximately 5-10% of patients, progress to a disseminated form of the disease...

Published: 1/4/2024 | Inventor(s): Mitch Magee, Douglas Lake

Keywords(s):

Category(s): Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors, Proteomic Assays/Reagents/Tools

Novel Biomarkers for Valley Fever

Valley Fever (VF) or coccidioidomycosis is a systemic fungal infection that is endemic to the Southwestern United States although it can occur in other parts of the world. Roughly 40% of VF patients experience vague or flu-like symptoms and approximately 5-10% of patients, progress to a disseminated form of the disease with potentially fatal consequences....

Published: 1/29/2024 | Inventor(s): Douglas Lake, Natalie Mitchell, Thomas Grys

Keywords(s):

Category(s): Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Medical Diagnostics/Sensors, Life Science (All LS Techs)

Metabolic Profiling for Rapid and Accurate Coccidioidomycosis Diagnostics

Valley Fever (VF) or coccidioidomycosis is a systemic fungal infection that is endemic to the Southwestern United States although it can occur in other parts of the world. Studies suggest that as few as 10 inhaled spores are sufficient to cause an infection. Roughly 40% of VF patients experience vague or flu-like symptoms and approximately 5-10% of...

Published: 11/21/2023 | Inventor(s): Haiwei Gu, Douglas Lake, Thomas Grys, Natalie Mitchell, Paniz Jasbi

Keywords(s):

Category(s): Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors

QSOX1 as an anti-neoplastic drug target

Despite tremendous scientific progress and treatment advances, cancer continues to be the leading cause of death worldwide, with approximately 14 million new cases and 8.2 million deaths in 2012 alone (WHO). Because invasion and metastasis are arguably the most dangerous characteristics of cancer, therapeutics that suppress these characteristics could...

Published: 7/15/2024 | Inventor(s): Douglas Lake, Benjamin Katchman

Keywords(s): Bio-Technology, Drug Screening, Therapeutics

Category(s): Cancer Therapeutics, Life Science (All LS Techs), Pharmaceuticals