Search Results - jacques+roberge

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Tricyclic Inhibitors of Ribosome‐Inhibiting Proteins
​ An image that shows p-stalk binding blockage would lead to the prevention of damage caused by Shiga or Ricin toxins Invention Summary: Shiga Toxin-producing E. coli (STEC) are very common bacteria that can cause infections that lead to approximately 100,000 illnesses, 3,000 hospitalizations, and about 90 deaths annually in the United States....
Published: 3/31/2025   |   Inventor(s): Jacques Roberge, Xiao-Ping Li, Anastasiia Tsymbal, Nilgun Tumer
Keywords(s):  
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
DEVELOPMENT OF SPECIFIC CRK-LIKE ADAPTOR PROTEIN INHIBITORS FOR CANCER THERAPY
NC5 inhibits tumor growth and prolongs survival in vivo. NC5 treatment inhibits TNBC tumor growth and prolongs mice survival in xenograft and PDX mouse models. (A) Survival of mice bearing MDA-MB-231-Luc orthotopic xenograft tumors following treatment with vehicle (black line), Gleevec (blue line), or NC5 (red line). (B) Survival of mice bearing PDX...
Published: 10/29/2024   |   Inventor(s): Dongfang Liu, Xuening Wang, Jacques Roberge
Keywords(s): Anti-cancer, Proteins
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cancer
PKC412 restores functionality of the keratin cytoskeleton in the skin disorder epidermolysis bullosa simplex
­​ ​ Invention Summary: Epidermolysis bullosa simplex (EBS) is a highly penetrant genetic condition that causes fragility of skin keratinocytes resulting in fluid-filled skin blisters that erode upon scratching or minor pressure on the skin. There is no good cure for EBS, and treatment typically involves preventive and/or supportive care...
Published: 10/21/2024   |   Inventor(s): Bishr Omary, Thomas Magin, Jacques Roberge, Katrin Rietscher, Pei Li
Keywords(s): Dermatology
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Rare Disease
Nipple Shield with Adhesive Lining and Conduit for Supplemental Nursing
Keeps Nipple Shield in Place and Allows Simultaneous Use of Supplemental Nursing Systems This nipple shield features a gecko-inspired adhesive inner surface and has a design that accommodates a supplemental nursing system (SNS). The breastfeeding accessories market will reach $1.6 billion by 2025. Standard nipple shields are prone to fall off easily...
Published: 6/27/2021   |   Inventor(s): Ge Qu, Bruce Spiess
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Others
Novel Ricin Inhibitors
(A) Model showing the interaction of Ricin toxin A (RTA) with the P stalk to access the sarcin/ricin loop (SRL) of the eukaryotic ribosome. 26S rRNA and 60S subunit are shown in light gray and dark gray, respectively. (B) The 50% inhibitory concentration (IC50) of fragments against RTA. Invention Summary: Ricin toxin is lethal to human at small doses,...
Published: 12/13/2024   |   Inventor(s): Nilgun Tumer, Xiao-Ping Li, Jacques Roberge, David Augeri, Bin Cao
Keywords(s): Drug Discovery/Screening
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
A New Method to Treat Asthma and Allergic Reaction
PBS PeptideIntranasal peptide treatment inhibits ILC2-dependent mucus productionInvention Summary:Although most patients with asthma respond to regular inhaled glucocorticoid (corticosteroid) therapy, 5% to 25% of people with asthma have more severe disease and do not respond...
Published: 12/10/2024   |   Inventor(s): Mark Siracusa, Jacques Roberge
Keywords(s): Autoimmune, Peptides, Respiratory Disease
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics