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Directly Sprayed 2D Nanomaterial Coatings on Body Surfaces for Health Monitoring (Case No. 2025-051)

Summary: UCLA researchers from the Department of Chemistry and Biochemistry have developed a novel coating that is directly sprayed on body surfaces for improved health monitoring, particularly for deep tissues. Background: Deep tissue activities, such as blood circulation and brain function, provide crucial insight into normal and pathological...

Published: 12/16/2024 | Inventor(s): Xiangfeng Duan, Yu Huang, Dehui Zhang

Keywords(s):

Category(s): Electrical, Electrical > Flexible Electronics, Electrical > Sensors, Materials, Materials > Nanotechnology, Medical Devices, Medical Devices > Monitoring And Recording Systems

3D PRINTING OF ORGANOID SLURRIES

3D PRINTING OF ORGANOID SLURRIES Researchers at Stanford have developed methods for 3D printing and post-biomanufacturing of organoid slurries in a high yield stress matrix. Biomanufactured tissues and organs on demand has been a long-standing challenge in the field of tissue engineering. Despite the advancements allowed by 3D bioprinting, current...

Published: 11/6/2024 | Inventor(s): Mark Syklyar-Scott, Jianyi Du

Keywords(s): Bioink, Matrix, Organoid, Printing

Category(s): Technology Classifications > Biology

Novel Kinase Inhibitory Thiazines

Summary The National Cancer Institute (NCI) seeks research co-development partners and/or licensees for a class of novel aplithianine-derived small molecule analogs that compete with ATP for binding on a range of clinically relevant kinases including: Oncogenic gene fusion DNAJB1-PRKACA (PKADJ) Wild type protein kinase A (PKA) Protein kinase...

Published: 12/20/2024 | Inventor(s): Barry O'Keefe, Lin Du, Brice Wilson, Ping Zhang, William Moore, Dongdong Wang, Juliana Martinez Fiesco, Ning Li

Keywords(s):

Category(s): Application, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, TherapeuticArea > Rare / Neglected Diseases, TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing

Reverse Thiazine Kinase Inhibitors

Published: 12/19/2024 | Inventor(s): Barry O'Keefe, Lin Du, Brice Wilson, Ping Zhang, William Moore, Dongdong Wang, Juliana Martinez Fiesco, Ning Li

Keywords(s):

Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, TherapeuticArea > Rare / Neglected Diseases, Collaboration Sought > Licensing

Novel Kinase Inhibitory Aplithianines

Published: 12/20/2024 | Inventor(s): Barry O'Keefe, Lin Du, Brice Wilson, Ping Zhang, William Moore, Dongdong Wang, Juliana Martinez Fiesco, Ning Li

Keywords(s):

Category(s): Application > Therapeutics, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, TherapeuticArea > Rare / Neglected Diseases, Collaboration Sought > Collaboration, Collaboration Sought > Licensing

S100A4 Monoclonal Antibody for Therapeutic and Diagnostic Use

Cancer metastasis are responsible for ~90% of cancer associated deaths. Recent studies suggest that immune cells play critical roles in promoting metastasis, especially myeloid cells from the bone marrow. UTHealth researchers, with researchers from The Methodist Hospital, observed a highly conserved expression of S100A4 in immune suppressive myeloid...

Published: 10/21/2024 | Inventor(s): Zhiqiang An, Ningyan Zhang

Keywords(s):

Category(s): Neurology/Neurosurgery, Oncology, Therapeutics

LILRB2 Monoclonal Antibody for Therapeutic and Diagnostic Uses of Neurodegenerative Diseases

Triggering Receptor Expressed on Myeloid cells 2 (TREM2) plays a key regulatory role in Alzheimer’s disease (AD) by controlling microglia activation and metabolic activities in brain tissues. TREM2 signaling inhibition is mediated by leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2). UTHealth inventors created and engineered...

Published: 10/21/2024 | Inventor(s): Zhiqiang An, Ningyan Zhang

Keywords(s):

Category(s): Neurology/Neurosurgery, Therapeutics

Steric Hindrance Effect of Additives for Tuning the Perovskite Crystal Orientation (Case No. 2024-023)

Summary: UCLA Researchers in the Department of Materials Science and Engineering have developed a method to tune perovskite crystal orientation for increased performance, energy efficiency, and reduced material defect with a variety of field applications, including solar cells and LEDs. Background: Perovskite holds considerable promise as a highly...

Published: 10/25/2024 | Inventor(s): Yang Yang, Chunqing Ma, Haoxiang Duan, Dong Meng

Keywords(s): Energy Efficiency, energy-efficient, Imaging, Liquid-Crystal Display, Nanocrystal, OLED, Optoelectronics, organic photo detector, organic photovoltaics, perovskite, perovskite devices, perovskite solar cell, photodetection, Solar Cell, X-ray detectors

Category(s): Chemical > Chemical Processing & Manufacturing, Energy & Environment > Energy Efficiency, Energy & Environment, Materials > Composite Materials, Optics & Photonics, Optics & Photonics > Fiber Optics, Materials > Functional Materials

Pegylated aminoglycoside compounds for enhanced treatment of biofilm infections

Pegylated aminoglycoside compounds, like m-PEG-tobramycin, combine antibiotics with polyethylene glycol to enhance solubility, stability, and bioavailability, effectively penetrating and disrupting biofilm infections resistant to standard treatments. Background Biofilm-associated infections present a significant challenge in medical and industrial...

Published: 9/16/2024 | Inventor(s): Hugh Smyth, Ju Du

Keywords(s):

Category(s): Life sciences > Therapeutics > Small molecule, Life sciences > Agriculture > Animal/veterinary

Oxynitidine Derivatives Useful as Inhibitors of Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) for Treating Cancer

Summary: The National Cancer Institute (NCI) is actively seeking potential licensees and/or co-development research collaboration partners interested in advancing oxynitidine derivatives as novel inhibitors of topoisomerase IB (TOP1) and tyrosyl-DNA phosphodiesterase 1 (TDP1) for cancer treatment. These TOPI and TDP1 inhibitors, when administered...

Published: 9/18/2024 | Inventor(s): Yves Pommier, Lin-kun An, Keli Agama, Evgeny Kiselev, Azhar Ravji

Keywords(s): Benzophenanthridine Derivatives, Benzophenanthridinone, Camptothecin, Dihydrobenzophenanthridine, IRINOTECAN, Oxynitidine, Pommier, Tdp1, TOP1, Topoisomerase 1B, Topotecan, Tyrosyl-DNA Phosphodiesterase 1

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Application > Therapeutics

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