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Engineering Asymmetrically Glycosylated IgG Antibodies

Application A novel method to develop asymmetrically glycosylated therapeutic monoclonal IgG antibodies for preventing and treating diseases like cancer, infectious diseases, and autoimmune disorders. Key Benefits Different IgG antibody glycoforms can be produced, each with its unique effector functions and biological and therapeutic effects. Potential...

Published: 5/30/2025 | Inventor(s): Eric J. Sundberg, Jonathan Du, Tala Azzam

Keywords(s): Antibodies, Immunology and Inflammation Treatments, Microbiology and Infectious Disease Treatments, Oncology Treatments

Category(s): TechPub Algolia > Therapeutics

High-Potency Biased β2-adrenergic Receptor Agonist for Treating Respiratory Diseases

Advantages Ultra-potent β2-adrenergic receptor agonist that stimulates cAMP production with sub-nanomolar potency (EC50 = 0.25nM) Biased signaling profile selectively activates Gαs-mediated cAMP signaling while avoiding β-arrestin2 recruitment, reducing receptor desensitization characteristic of traditional treatments such as albuterol Maintains...

Published: 5/27/2025 | Inventor(s): Stephen Liggett, Donghwa Kim, Yu Chen, Jesper Madsen, Steven An

Keywords(s): Pharmaceuticals, Respiratory Diseases Treatment

Category(s): Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals

Novel Potential Glaucoma Therapy via Secretome Treatment of Schlemm’s Canal Endothelial Cells

Advantages: Minimally invasive secretome therapy enhances Schlemm’s canal function, offering a non-surgical alternative to glaucoma treatment Secretome therapy promotes cellular repair and wound healing, addressing TM damage beyond Increased Intraocular Pressure (IOP) reduction Secretome therapy enhances aqueous outflow by upregulating tight...

Published: 4/17/2025 | Inventor(s): Rong Du, Yiqin Du, Enzhi Yang

Keywords(s): Ophthalmology

Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical, Technology Classifications > Chemistry

Novel Potential Glaucoma Therapy via Secretome Treatment of Schlemm’s Canal Endothelial Cells

Published: 4/17/2025 | Inventor(s): Rong Du, Yiqin Du, Enzhi Yang

Keywords(s): Ophthalmology

Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical, Technology Classifications > Chemistry

IgG-Specific Enzymes with Reduced Residual Glycan Hydrolysis

Application Novel enzymes for IgG-specific glycosynthesis. Key Benefits Nearly full glycosylation of IgG antibodies. Improved antibody-mediated effector function properties. No measurable residual hydrolysis activity. Market Summary The global monoclonal antibodies market is experiencing significant growth due to the rising prevalence of chronic...

Published: 5/30/2025 | Inventor(s): Eric J. Sundberg, Jonathan Du, Tala Azzam

Keywords(s): Antibodies, Cardiovascular Treatments, Immunology and Inflammation Treatments, Oncology Treatments

Category(s): TechPub Algolia > Research Tools

Directly Sprayed 2D Nanomaterial Coatings on Body Surfaces for Health Monitoring (Case No. 2025-051)

Summary: UCLA researchers from the Department of Chemistry and Biochemistry have developed a novel coating that is directly sprayed on body surfaces for improved health monitoring, particularly for deep tissues. Background: Deep tissue activities, such as blood circulation and brain function, provide crucial insight into normal and pathological...

Published: 4/28/2025 | Inventor(s): Xiangfeng Duan, Yu Huang, Dehui Zhang

Keywords(s):

Category(s): Electrical, Electrical > Flexible Electronics, Electrical > Sensors, Materials, Materials > Nanotechnology, Medical Devices, Medical Devices > Monitoring And Recording Systems

3D PRINTING OF ORGANOID SLURRIES

3D PRINTING OF ORGANOID SLURRIES Researchers at Stanford have developed methods for 3D printing and post-biomanufacturing of organoid slurries in a high yield stress matrix. Biomanufactured tissues and organs on demand has been a long-standing challenge in the field of tissue engineering. Despite the advancements allowed by 3D bioprinting, current...

Published: 11/6/2024 | Inventor(s): Mark Syklyar-Scott, Jianyi Du

Keywords(s): Bioink, Matrix, Organoid, Printing

Category(s): Technology Classifications > Biology

Novel Kinase Inhibitory Thiazines

Summary The National Cancer Institute (NCI) seeks research co-development partners and/or licensees for a class of novel aplithianine-derived small molecule analogs that compete with ATP for binding on a range of clinically relevant kinases including: Oncogenic gene fusion DNAJB1-PRKACA (PKADJ) Wild type protein kinase A (PKA) Protein kinase...

Published: 4/22/2025 | Inventor(s): Barry O'Keefe, Lin Du, Brice Wilson, Ping Zhang, William Moore, Dongdong Wang, Juliana Martinez Fiesco, Ning Li

Keywords(s):

Category(s): Application, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing, TherapeuticArea > Rare/Neglected Diseases

Reverse Thiazine Kinase Inhibitors

Published: 4/22/2025 | Inventor(s): Barry O'Keefe, Lin Du, Brice Wilson, Ping Zhang, William Moore, Dongdong Wang, Juliana Martinez Fiesco, Ning Li

Keywords(s):

Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing, TherapeuticArea > Rare/Neglected Diseases

Novel Kinase Inhibitory Aplithianines

Published: 5/14/2025 | Inventor(s): Barry O'Keefe, Lin Du, Brice Wilson, Ping Zhang, William Moore, Dongdong Wang, Juliana Martinez Fiesco, Ning Li

Keywords(s):

Category(s): Application > Therapeutics, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Rare/Neglected Diseases

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