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Antisense oligonucleotides for rescuing splicing mutations in hotspot exons
An antisense oligonucleotide to rescue multiple splicing mutations in hotspot exons Overview Research by William Fairbrother at Brown University centers around a therapeutic use of ASOs to enhance splicing for various mutations using a single ASO. This can allow for the expansion of treatment options for a broader range of patients with the same underlying...
Published: 10/29/2025   |   Inventor(s): William Fairbrother, Jeremiah Buerer, Chaorui Duan
Keywords(s):  
Category(s): Assay, Therapeutics
Tumor-pH–Triggered Doxorubicin Prodrug with On-Demand Shelf-Stable Precursor
This invention introduces a small-molecule doxorubicin prodrug that remains inert in blood and rapidly activates in the mildly acidic tumor microenvironment. Featuring a shelf-stable maleimide pre-prodrug that converts on demand to the ultra-acid-labile DMA form, it enables targeted chemotherapy with improved selectivity, scalable synthesis, and reduced...
Published: 10/10/2025   |   Inventor(s): Ming An, Lan Yao, Vladyslav Nazarenko
Keywords(s): Technologies
Category(s): Campus > Binghamton University
A Breakthrough for Corneal Regeneration: Bioengineered Membrane Immerged with Stem Cell Secretome/Extracellular Vesicles
Advantages Donor-Free Alternative: Eliminates the need for donor corneas in treating shallow corneal opacity, utilizes secretomes and/or extracellular vesicles from stem cells to promote natural healing and tissue regeneration Enhanced Healing Performance: Improves wound closure and reduce fibrosis Sustained and controlled Therapeutic Release ...
Published: 9/29/2025   |   Inventor(s): Rohit Sharma, Yiqin Du
Keywords(s): Ophthalmology
Category(s): Technology Classifications > Chemistry, Technology Classifications > Chemistry > Polymers, Technology Classifications > Medical, Technology Classifications > Medical > Biomaterials, Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications > Medical > Ophthalmology
Ampule-Based Synthesis of Sulfur-Porous Carbon Composites for Lithium-Sulfur Batteries
Background Lithium/sulfur (Li/S) batteries are garnering significant attention as a promising solution for next-generation electrochemical energy storage. Their potential to revolutionize the battery industry stems from several key advantages that address the limitations of current lithium-ion (Li-ion) technology. These advantages include an exceptionally...
Published: 10/30/2025   |   Inventor(s): Yoon Hwa, David Wright, Yuhui An
Keywords(s): Chemicals, Energy storage, Engineering, Materials, Nanomaterials, Synthesis
Category(s): Energy & Power, Physical Science, Advanced Materials/Nanotechnology, Semiconductors, Materials & Processes
Large-Area Solution-Processed Ionomer-Interlayered Bulk Monolayer MOS2 Membranes With Thickness-Scalable Bright Luminescence and Dual Electron-Ion Transport (Case No. 2025-281)
Summary: UCLA researchers have developed a novel hybrid 2D material platform that significantly improves the utility and optical performance of monolayer molybdenum disulfide (MoS2) by integrating a Nafion interlayer. Background: Monolayer transition metal dichalcogenides (TMDs), particularly MoS2, have shown promise in the fields of optics and...
Published: 9/25/2025   |   Inventor(s): Xiangfeng Duan, Yu Huang, Boxuan Zhou
Keywords(s):  
Category(s): Materials, Materials > Functional Materials, Materials > Semiconducting Materials, Materials > Membranes, Materials > Composite Materials, Electrical, Electrical > Flexible Electronics, Electrical > Electronics & Semiconductors, Electrical > Sensors, Chemical, Chemical > Chemical Sensors, Chemical > Polymers
A General Cation-Exchange Approach to Magnetic Intercalation Superlattices (Case No. 2025-9A1)
Summary: UCLA researchers in the Department of Chemistry have developed a general cation-exchange approach for tunable magnetic intercalation superlattices. Background: Layered materials are crucial for engineering quantum and magnetic phenomena at the atomic scale. Magnetic intercalation superlattices, a type of layered materials, enable tunable...
Published: 7/24/2025   |   Inventor(s): Xiangfeng Duan, Yu Huang, Jingxuan Zhou
Keywords(s): Advanced Computing / AI, advanced packaging, Cation exchange, doping control, Fabrication Technologies, ferromagnetic semiconductor, layered materials, magnetic coupling, magnetic intercalation superlattices, quantum communication, Quantum Computer, quantum computing materials, Quantum Dot, quantum error correction (QEC), quantum incompressible fluid, quantum key, quantum network, quantum processing, quantum processor, room-temperature superconductivity, spin textures, spintronics, trapped ion quantum processor, tunable ferromagnetism, Van der Waals, Van Der Waals Force, VIN group metals
Category(s): Materials, Materials > Nanotechnology, Materials > Functional Materials, Materials > Semiconducting Materials, Materials > Fabrication Technologies, Materials > Metals, Optics & Photonics
Surface Oxophilic Single Atom Decoration of PT Catalyst for Anion Exchange Membrane Fuel Cells (Case No. 2025-263)
Summary: Researchers at UCLA's Department of Chemistry and Biochemistry have developed a novel catalyst design using oxophilic single-atom decorations that enhances the performance and durability of platinum (Pt) catalysts in alkaline exchange membrane fuel cells. Background: Hydrogen fuel cells are a promising alternative to internal combustion...
Published: 10/24/2025   |   Inventor(s): Xiangfeng Duan, Yu Huang, Chengzhang Wan
Keywords(s): anion exchange membrane fuel cells (AEMFCs), Catalysts, catalytic hydrogenation, clean energy, clean energy consumption, clean material production, Composite Material, Composite Materials, Construction Materials, Electrocatalyst, electrochemically active surface area, high-durability catalysts, Hydrogen, Hydrogen oxidation reaction, hydrogen oxidation reaction (HOR), hydrogen production, low overpotential catalysis, mass activity, material science, Materials, meta materials, Methane Reformer Hydrogen Production, microarchitectured materials, Nanomaterials, nanostructured materials, Nanotechnology, oxygen oxidation reaction, oxygen reduction reaction (ORR), Platinum group metal catalysts, proton exchange membrane fuel cells (PEMFCs), proton exchange water membrane electrolyzer (PEMWE), Rhodium-decorated Platinum nanowires (SARh-PtNW), specific activity, transition metal catalysts
Category(s): Materials, Materials > Nanotechnology, Materials > Functional Materials, Energy & Environment, Energy & Environment > Energy Generation, Energy & Environment > Energy Efficiency, Energy & Environment > Energy Transmission, Chemical, Chemical > Chemical Processing & Manufacturing, Chemical > Synthesis, Chemical > Catalysts
High-Potency Biased β2-adrenergic Receptor Agonist for Treating Respiratory Diseases
Advantages Ultra-potent β2-adrenergic receptor agonist that stimulates cAMP production with sub-nanomolar potency (EC50 = 0.25nM) Biased signaling profile selectively activates Gαs-mediated cAMP signaling while avoiding β-arrestin2 recruitment, reducing receptor desensitization characteristic of traditional treatments such as albuterol Maintains...
Published: 5/27/2025   |   Inventor(s): Stephen Liggett, Donghwa Kim, Yu Chen, Jesper Madsen, Steven An
Keywords(s): Pharmaceuticals, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals
Novel Potential Glaucoma Therapy via Secretome Treatment of Schlemm’s Canal Endothelial Cells
Advantages: Minimally invasive secretome therapy enhances Schlemm’s canal function, offering a non-surgical alternative to glaucoma treatment Secretome therapy promotes cellular repair and wound healing, addressing TM damage beyond Increased Intraocular Pressure (IOP) reduction Secretome therapy enhances aqueous outflow by upregulating tight...
Published: 10/14/2025   |   Inventor(s): Rong Du, Yiqin Du, Enzhi Yang
Keywords(s): Ophthalmology
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical, Technology Classifications > Chemistry
Novel Potential Glaucoma Therapy via Secretome Treatment of Schlemm’s Canal Endothelial Cells
Advantages: Minimally invasive secretome therapy enhances Schlemm’s canal function, offering a non-surgical alternative to glaucoma treatment Secretome therapy promotes cellular repair and wound healing, addressing TM damage beyond Increased Intraocular Pressure (IOP) reduction Secretome therapy enhances aqueous outflow by upregulating tight...
Published: 10/14/2025   |   Inventor(s): Rong Du, Yiqin Du, Enzhi Yang
Keywords(s): Ophthalmology
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical, Technology Classifications > Chemistry
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