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Pegylated aminoglycoside compounds for enhanced treatment of biofilm infections
Pegylated aminoglycoside compounds, like m-PEG-tobramycin, combine antibiotics with polyethylene glycol to enhance solubility, stability, and bioavailability, effectively penetrating and disrupting biofilm infections resistant to standard treatments. Background Biofilm-associated infections present a significant challenge in medical and industrial...
Published: 9/16/2024   |   Inventor(s): Hugh Smyth, Ju Du
Keywords(s):  
Category(s): Life sciences > Therapeutics > Small molecule, Life sciences > Agriculture > Animal/veterinary
Oxynitidine Derivatives Useful as Inhibitors of Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) for Treating Cancer
Summary: The National Cancer Institute (NCI) is actively seeking potential licensees and/or co-development research collaboration partners interested in advancing oxynitidine derivatives as novel inhibitors of topoisomerase IB (TOP1) and tyrosyl-DNA phosphodiesterase 1 (TDP1) for cancer treatment. These TOPI and TDP1 inhibitors, when administered...
Published: 9/18/2024   |   Inventor(s): Yves Pommier, Lin-kun An, Keli Agama, Evgeny Kiselev, Azhar Ravji
Keywords(s): Benzophenanthridine Derivatives, Benzophenanthridinone, Camptothecin, Dihydrobenzophenanthridine, IRINOTECAN, Oxynitidine, Pommier, Tdp1, TOP1, Topoisomerase 1B, Topotecan, Tyrosyl-DNA Phosphodiesterase 1
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Application > Therapeutics
Antibodies against CD5L for therapeutic and diagnostic uses
Provided herein are anti-CD5L monoclonal antibodies. Further provided herein are methods of use thereof for the treatment of a disease or disorder, such as cancer. UTHealth Ref. No.: 2020-0016 Inventors: Dr. Zhiqiang An and Dr. Ningyan Zhang at UTHealth; Dr. Anil Sood at UT M.D. Anderson Cancer Center Patent Status: PCT application PCT/US2021/025429...
Published: 5/28/2024   |   Inventor(s): Zhiqiang An, Ningyan Zhang, Anil Sood
Keywords(s):  
Category(s): Biologics, Oncology, Therapeutics
Giant Second-Harmonic Generation in Bulk Monolayer MoS2 Thin Films (Case No. 2024-186)
Summary: UCLA researchers in the department of Chemistry and Biochemistry have developed a method to control electron density in molybdenum disulfide (MoS2) thin films that can be used to improve optical material characteristics. Background: Second harmonic generation (SHG) is an optical process in which light interacts with a nonlinear material...
Published: 7/3/2024   |   Inventor(s): Xiangfeng Duan, Yu Huang, Boxuan Zhou
Keywords(s): Adaptive Optics, Algorithm Optical Coherence Tomography, all-optical diffractive computing, all-optical transformation, Atomic Force Microscopy Optical Tweezers, bulk monolayer, Composite Material, Composite Materials, Dispersion (Optics), Electro-Optics, Focus (Optics), Functional Materials, Infrared Electromagnetic Spectrum Dispersion (Optics), linear optics, material characterization, Materials, molybdenum disulfide (MOS2), monolayer, Nanomaterials, Near-Field Scanning Optical Microscope, nonlinear dynamics, Nonlinear Optics, non-linear optics, Nonlinear Optics Molecular Dynamics, Optical Coherence , Optical Communication , Optical computing, optical implementation, Optical networks, optical processor, optical transmission, Optics Parabolic Reflector Curved Mirror, Optoelectronic materials, reverse engineered optical system, second harmonic generation, start to end optics design, Surgical Instrument Optical Coherence Tomography
Category(s): Materials, Materials > Functional Materials, Optics & Photonics, Chemical, Chemical > Instrumentation & Analysis
A Method for Label-Free, Non-Invasive Acquisition and Mapping of -Omics Data
This technology describes a novel process to generate -omics data, such as genomics, proteomics, and more, through optical imaging. The invention is intended to implement spatial imaging techniques to identify optical imaging markers that can be predictors of -omics. This technology has potential for usage in a variety of fields including in vivo or...
Published: 6/6/2024   |   Inventor(s): Travis Sawyer, Suzann Duan, Thomas Graham Knapp
Keywords(s):  
Category(s): Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Life Sciences > Diagnostics
A Library of Layered Hybrid Superlattices and Artificial Quantum Solids (Case No. 2024-098)
Summary: UCLA researchers have developed a novel approach for the generation of hybrid superlattices with tunable properties. Background: Heterostructures are composed of two or more semiconductor crystals with interfaces across which chemical makeup changes, and superlattices are simply composed of nanoscale layers that allow quantum confinement...
Published: 8/7/2024   |   Inventor(s): Xiangfeng Duan, Yu Huang, Jingyuan Zhou
Keywords(s):  
Category(s): Electrical, Electrical > Quantum Computing, Materials, Materials > Functional Materials, Materials > Semiconducting Materials
Monoclonal Antibodies Against PCDH7 for Therapeutic and Diagnostic Use
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-associated deaths worldwide. UTHealth researchers discovered that the cell surface protein Protocadherin 7 (PCDH7) is highly expressed in NSCLC and promotes lung cancer development. Inventors at UTH in collaboration with Dr. O’Donnell’s group at UTSW have discovered a panel...
Published: 5/28/2024   |   Inventor(s): Zhiqiang An, Ningyan Zhang, Kathryn O'Donnell
Keywords(s):  
Category(s): Diagnostics, Oncology, Therapeutics, Biologics
Intralipid as a Contrast Agent to Enhance Subsurface Blood Flow Imaging
This technology includes a blood flow imaging method that allows for a higher density of smaller particles to be detected. Current imaging methods that are based on Doppler measurements are limited by the discontinuity in the capillary flow in the space between red blood cells. The core technology is to use a scattering agent to enhance capillary flow...
Published: 8/12/2024   |   Inventor(s): Congwu Du, Yingtian Pan, Nora Volkow
Keywords(s):  
Category(s): Application > Diagnostics, Application > Medical Devices, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, ResearchProducts > Computational models/software, TherapeuticArea > Cardiology, TherapeuticArea > Neurology, TherapeuticArea > Oncology, TherapeuticArea > Ophthalmology, TherapeuticArea > Radiology
A Chemical-Dedoping Strategy to Tailor Electron Density in Molecular-Intercalated Bulk Monolayer MOS2 (Case No. 2024-022)
Summary: UCLA researchers in the Department of Chemistry & Biochemistry have developed a novel strategy to decouple the interlayer interactions in bulk MoS2 to produce a bulk material with desirable monolayer properties. Background: Molybdenum disulfide (MoS2) is a popular and well-studied 2D semiconducting layered material. A single layer, or...
Published: 8/8/2024   |   Inventor(s): Xiangfeng Duan, Yu Huang, Boxuan Zhou
Keywords(s): bulk material, bulk monolayer, chemical dedoping, direct bandgap, Doping (Semiconductor), Electronics & Semiconductors, exciton, indirect bandgap, intercalated materials, Microelectronics Semiconductor Device Fabrication, molybdenum disulfide (MOS2), monolayer, Optoelectronic materials, Organic Semiconductor, photoluminescence, photon absorption, Semiconductor, semiconductor chip foundries, Semiconductor Device, Semiconductor Device Fabrication, Semiconductor Ohmic Contact, Semiconductor Risk Assessment, Semiconductor Sapphire, Semiconductors, spin polarization, valley polarization, zzsemiconducting materials
Category(s): Materials, Materials > Functional Materials, Materials > Semiconducting Materials, Electrical, Electrical > Electronics & Semiconductors
A Potent Short Hairpin RNA (SHRNA734) to Positively Select and Eliminate Genetically Modified Cells (UCLA Case No. 2016-524)
BACKGROUND: Gene therapy strategies to modify human stem cells hold great promise for curing many human diseases. However, previous clinical studies have met with limited success, largely due to the low engraftment of gene modified stem cells. One strategy to overcome this challenge involves engineering stem cells in which HPRT expression is knocked...
Published: 3/8/2024   |   Inventor(s): Dong Sung An, Saki Shimizu
Keywords(s):  
Category(s): Therapeutics > Gene Therapy And Editing, Therapeutics > Infectious Diseases
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