Search Results - application

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Broadly neutralizing influenza hemagglutinin stem-directed antibodies
In 2023, the World Health Organization (WHO) reported roughly 3 to 5 million cases of severe influenza worldwide, resulting in approximately 290,000 to 650,000 deaths. Given the high disease burden, the needs for both prophylactic and therapeutic influenza strategies remain significant. However, current treatments for influenza are susceptible to resistance...
Published: 5/8/2025   |   Inventor(s): Sarah Andrews, Grace Mantus, Ankita Chopde, Adrian Creanga, Rebecca Gillespie, Masaru Kanekiyo, Julie Raab
Keywords(s):  
Category(s): Application, Application > Therapeutics, Application > Vaccines, Collaboration Sought, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Collaboration Sought > Materials Available, ResearchProducts > Antibodies, TherapeuticArea > Infectious Disease, TherapeuticArea > Immunology
A Novel Strategy to Produce 6-cys Proteins Based on Pfs230D1 Domain Fusions
The Plasmodium parasite has a complex lifecycle during human infection and in the mosquito vector. Most advanced malaria vaccine candidates can confer only partial, short-term protection in malaria-endemic areas. A means of breaking the transmission of malaria to subsequent individuals could prevent a significant amount of human disease. The primary...
Published: 5/8/2025   |   Inventor(s): Patrick Duffy, Jonathan Renn
Keywords(s):  
Category(s): Application, Application > Research Materials, Application > Therapeutics, Application > Vaccines, Collaboration Sought, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, ResearchProducts > Sequences, TherapeuticArea > Immunology, TherapeuticArea > Infectious Disease
Francisella Lipids as Broad Anti-inflammatory Therapeutics
Anti-inflammatory treatments, particularly those used in the context of viral infection, have been shown to greatly inhibit the overall immune response, which can result in poor immunity and failure to control or clear the infection. Novel alternatives that can effectively attenuate inflammation without the more serious side effects of steroid medications...
Published: 5/13/2025   |   Inventor(s): Catharine Bosio, Glenn Nardone, Robin Ireland
Keywords(s):  
Category(s): Application, Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, TherapeuticArea > Immunology
Fluorinated MU-Opioid Receptor Agonists
Summary: Investigators at the National Institute on Drug Abuse seek co-development partners and/or licensees for collection of mu opioid receptor (MOR) agonists as alternatives for existing compounds. Description of Technology: Although existing opioids are excellent analgesics and useful as positron emission tomography (PET) radiotracers, they come...
Published: 4/22/2025   |   Inventor(s): Michael Michaelides, Juan Gomez, Kenner Rice, Agnieszka Sulima, Michael Baumann
Keywords(s):  
Category(s): Application, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Immunology, TherapeuticArea > Neurology, TherapeuticArea > Radiology, Collaboration Sought > Licensing
Suppression Of Uveitis By A STAT3 Single Domain Antibody
Summary: The National Eye Institute seeks research co-development partners and/or licensees for a STAT3 antibody that can suppress uveitis. Description of Technology: Uveitis is caused by inflammation in the eye that causes pain and reduce vision in affected patients. Rates of uveitis in the United States occurs 1 in every 200 people with eye-related...
Published: 4/22/2025   |   Inventor(s): Charles Egwuagu, Sunanda Singh
Keywords(s):  
Category(s): Application, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Neurology, TherapeuticArea > Ear, Nose, & Throat, Collaboration Sought > Licensing
Novel Kinase Inhibitory Thiazines
Summary The National Cancer Institute (NCI) seeks research co-development partners and/or licensees for a class of novel aplithianine-derived small molecule analogs that compete with ATP for binding on a range of clinically relevant kinases including: Oncogenic gene fusion DNAJB1-PRKACA (PKADJ) Wild type protein kinase A (PKA) Protein kinase...
Published: 4/22/2025   |   Inventor(s): Barry O'Keefe, Lin Du, Brice Wilson, Ping Zhang, William Moore, Dongdong Wang, Juliana Martinez Fiesco, Ning Li
Keywords(s):  
Category(s): Application, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing, TherapeuticArea > Rare/Neglected Diseases
Improved Methods For Cryopreservation Of Cells, Tissues, And Organs
Summary: The National Eye Institute seeks research co-development partners and/or licensees for novel methods of cryopreserving cells, tissues, and organs via FOXO1 activation and other mechanisms. Description of Technology: The cornea is a critical part of the eye that helps prevent debris from entering and refracts light for proper vision. Corneal...
Published: 5/15/2025   |   Inventor(s): Jingxing Ou, Kiyoharu Miyagishima, Guanghui Jin, Wei Li, Lihao Ge
Keywords(s):  
Category(s): Application, Application > Research Materials, Collaboration Sought > Collaboration, TherapeuticArea > Ear, Nose, & Throat, Collaboration Sought > Licensing
TYROSINASE Gene Therapy for Oculocutaneous Albinism type 1A
Summary: The National Eye Institute seeks research co-development partners and/or licensees for an adeno-associated viral gene therapy for Oculocutaneous Albinism type 1A. Description of Technology: Oculocutaneous albinism (OCA) is a genetically heterogeneous congenital disorder characterized by decreased or absent pigmentation in the hair,...
Published: 4/22/2025   |   Inventor(s): Brian Brooks, Aman George
Keywords(s):  
Category(s): Application, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Ophthalmology, TherapeuticArea > Ear, Nose, & Throat, Collaboration Sought > Licensing, TherapeuticArea > Rare/Neglected Diseases
Free Breathing Motion Corrected Pixel-wise MRI Myocardial T1 Parameter Mapping for Clinical Cardiac Imaging
This technology includes a method for performing cardiac imaging without the need for the patient to hold their breath. Free breathing pixel-wise myocardial T1 parameter mapping includes performing a free-breathing scan of a cardiac region at a plurality of varying saturation recovery times to acquire a k-space dataset; generating an image dataset based...
Published: 8/12/2024   |   Inventor(s): Bruce Spottiswoode, Peter Kellman
Keywords(s):  
Category(s): Application, Application > Medical Devices, Application > Software / Apps, ResearchProducts > Computational models/software, ResearchProducts > Research Equipment, TherapeuticArea > Cardiology
Selective A3 Adenosine Receptor Agonists for the Treatment of Chronic Neuropathic Pain and Other Conditions
This technology includes the creation and use of A3 adenosine receptor (A3AR)-selective agonists for treating chemotherapy-induced peripheral neuropathy, chronic neuropathic pain, rheumatoid arthritis, psoriasis, and other conditions. A3 receptors for adenosine are found in most cells and endogenous activation of the A3 receptors can result in apoptosis,...
Published: 8/12/2024   |   Inventor(s): Daniela Salvemini, Dilip Tosh, Kenneth Jacobson
Keywords(s):  
Category(s): Application, Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Cardiology, TherapeuticArea > Dermatology, TherapeuticArea > Immunology, TherapeuticArea > Oncology
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