Search Results - zeyuan+(johnson)+chen

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A Process for Identifying Health Modifying Interventions Through Epigenetic Prediction (Case No. 2023-107)
Summary: UCLA researchers in the Department of Neurology have developed a novel method that leverages epigenetic markers to identify recommended and necessary health interventions. Background: Disease risk prediction and intervention involves identifying individuals or populations with a higher likelihood of developing a particular condition based...
Published: 3/22/2024   |   Inventor(s): Noah Zaitlen, Eran Halperin, Elior Rahmani, Michael Thompson, Zeyuan (Johnson) Chen
Keywords(s): Clinical decision support system, clinical outcome, Clinical Trial, disease outcome, Epigenetics, health risk assessment, outcome probability, patient outcome, prognostic, Public Health, public health monitoring, Risk Assessment, risk reduction, risk score, Simulation & Modeling, statistical modeling, treatment efficacy
Category(s): Software & Algorithms, Software & Algorithms > Data Analytics, Software & Algorithms > Digital Health, Software & Algorithms > Statistical Models, Medical Devices, Medical Devices > Monitoring And Recording Systems
Novel Small Molecule Inhibitors Targeting Clostridioides Difficile Sporulation
­Advantages: The development of DBO compounds represents a novel therapeutic approach to tackling CDI. By inhibiting C. difficile sporulation, DBO compounds address a major cause of CDI recurrence, reducing the likelihood of patients experiencing repeated infections. DBO compounds improve the effectiveness of existing antibiotics used to treat...
Published: 10/2/2023   |   Inventor(s): Yu Chen, Michael Sacco, James Leahy, Elena Bray, Xingmin Sun, Xiujun Zhang
Keywords(s): Drug Discovery, Infectious Diseases Treatment
Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Biotechnology
Novel Multi-Omics Aging Clock
­A multi-omics clock analyzes multiple layers of omics data with machine learning to predict remaining lifespan of mammals, particularly for animal model studies. Large omics data sets may be used from combinations of genomics, proteomics, lipids, etc. available from blood or other simple sample collection. This tool can robustly capture changes...
Published: 3/12/2024   |   Inventor(s): George Sutphin, Samuel Freitas, Megha Padi, Chen Chen
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Simulators and Modeling Tools
Autonomous Drone for railroad track inspection
Reference #: 01564 The University of South Carolina is offering licensing opportunities for Autonomous Drone for railroad track inspection Background: The current practices suffer from three main drawbacks: 1) Human pilot cost is significant. The schedule of the drone-based track inspection is contingent on the pilot’s availability rather than...
Published: 3/15/2023   |   Inventor(s): Yu Qian, Yi Wang, Chen Chen
Keywords(s): autonomous drone, flight control, image processing, railroad track inspection, self-navigation
Category(s): Engineering and Physical Sciences
Tetrazole & Coumarin Phosphonate Based Broad-Spectrum Beta-Lactamase Inhibitors
Competitive Advantages Combats bacterial antibiotic resistance to β-Lactamase Effectively inhibits against the different classes of β-Lactamase Enhances effectiveness of current β-lactam antibiotics treatments Summary Our inventors have discovered tetrazole and coumarin phosphonate based compounds can actively inhibit...
Published: 6/27/2024   |   Inventor(s): Yu Chen, Orville Pemberton, Adam Renslo, Priyadarshini Jaishankar
Keywords(s): Infectious Diseases Treatment, Pharmaceuticals
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical
Beta-Lactamase Inhibitor Compositions, Methods of Use, and Methods of Treatment
Competitive Advantages Can restore the efficacy of beta-lactam antibiotics Overcomes antibiotic resistance May help to develop new antibiotic treatment regimens Treats multi-drug resistant organisms Summary Our researchers have developed compositions comprised of a beta-lactamase inhibitor and methods of use to treat various infections and...
Published: 6/27/2024   |   Inventor(s): Adam Renslo, Derek Nichols, Priyadarshini Jaishankar, Yu Chen, Erica Lauterwasser
Keywords(s): Infectious Diseases Treatment, Pharmaceuticals
Category(s): Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical
2020-862 Early Prediction of Mechanical Ventilation Need in COVID-19 Patients Using Clinician-Constrained Decision Trees
SUMMARYUCLA researchers in the Department of Computer Science have developed a tree model with machine learning to determine the need for mechanical ventilators, which is important during a shortage of mechanical ventilators in a hospital.BACKGROUNDMechanical ventilation is used to help a patient breath when they find it difficult to breathe on their...
Published: 7/19/2023   |   Inventor(s): Elior Rahmani, Brian Hill, Zeyuan (Johnson) Chen, Eran Halperin, Vladimir Manuel
Keywords(s):  
Category(s): Software & Algorithms > Programs
2015-671 Underground Shafts for Hydrogen Storage
SummaryResearchers at UCLA have developed an underground drilled shaft concept for storage of hydrogen or other gases.BackgroundOne challenge in creating a hydrogen economy is developing hydrogen gas storage solutions. Increased interest has helped the global hydrogen storage market grow to $2.6 billion in 2016, and it is expected to reach over $5...
Published: 7/19/2023   |   Inventor(s): Adrienne Lavine, Hossein Kavehpour, Dante Simonetti, Richard Wirz, Chen Chen, Gabriela Bran, Gopinath Warrier, Hamarz Aryafar, Jonathon Kennedy, Joshua Jordan, Keith Lovegrove
Keywords(s): Energy & Water
Category(s): Energy & Environment > Energy Generation > Solar, Energy & Environment > Energy Storage
Designed Defects in Laminate Composites
Designed Defects in Laminate Composites Need: As defects are a common problem occurring in laminated composite materials, it is important to determine whether a defect exists in laminated parts or structures. A conventional method of creating a delamination defect involves the insertion of a thin plastic membrane in the composite sample to simulate...
Published: 8/13/2020   |   Inventor(s): Joseph Mello, John Chen, Luz Gomez
Keywords(s):  
Category(s): Engineering, Mechanical, Materials
Mitochondrial-Targeted Peptide Modulators of Delta Protein Kinase C Interaction with the d-subunit of F1Fo ATP Synthase/ATPase as Therapeutics Against Cardiac Injury
Current State of the Art: Current clinical therapy for heart attack victims focuses on the rapid restoration of blood flow by thrombolysis, angioplasty, stenting and when appropriate surgical coronary artery bypass grafts. Problems with the Current Art: The majority of cardiac cell death associated with a heart attack actually occurs during the...
Published: 4/29/2020   |   Inventor(s): John Johnson, Tiffany Tuyen Nguyen, Mourad Ogbi
Keywords(s): Cardiovascular, Heart Attack, Therapeutics
Category(s): Therapeutics
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