Search Results - yanming+zhao

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Tumor-pH–Triggered Doxorubicin Prodrug with On-Demand Shelf-Stable Precursor
This invention introduces a small-molecule doxorubicin prodrug that remains inert in blood and rapidly activates in the mildly acidic tumor microenvironment. Featuring a shelf-stable maleimide pre-prodrug that converts on demand to the ultra-acid-labile DMA form, it enables targeted chemotherapy with improved selectivity, scalable synthesis, and reduced...
Published: 10/10/2025   |   Inventor(s): Ming An, Lan Yao, Vladyslav Nazarenko
Keywords(s): Technologies
Category(s): Campus > Binghamton University
Multi-parametric Acoustic, Optical and Mechanical Imaging of Cervical Tissue Insufficiencies to Predict Preterm Birth
An enhanced image-guidance system that integrates ultrasound and photoacoustic into existing ablation systems to provide an enhanced image-guidance system for identification of cervical tissue changes during pregnancy and postpartum. Technology Summary Preterm delivery is a main cause of perinatal morbidity and mortality worldwide, which is associated...
Published: 10/1/2025   |   Inventor(s): Mohammad Mehrmohammadi, Sonia Hassan, Edgar Hernandez-Andrade, Yan Yan, Maryam Basij
Keywords(s): Driving Lifelong Health
Category(s): Technology Category > Women's Health, Technology Category > Medical Devices, Technology Category > Life Science, Technology Category > Imaging, Technology Category > Acoustics
Self-Supervised Quantization-Aware Knowledge Distillation
Background Deep neural networks (DNNs) are an important tool in enhancing deep learning capabilities, but they have substantial computational and memory requirements. Quantization is one of the important model compression approaches to address the mismatch between resource-hungry DNNs and resource-constrained devices, by converting the full-precision...
Published: 6/27/2025   |   Inventor(s): Kaiqi Zhao, Ming Zhao
Keywords(s):  
Category(s): Physical Science, Artificial Intelligence/Machine Learning, Wireless & Networking
DNA Gridiron
Self-assembling nucleic acid molecules have been utilized extensively for constructing unique nanoscale structures, and designing increasingly complex structures is a top nanotechnology challenge. Current methods to create NDA nanostructures are restricted to discrete domains of parallel lines as a result of the double crossover based unit motif, which...
Published: 2/13/2025   |   Inventor(s): Dongran Han, Hao Yan
Keywords(s): DNA nanotechnology
Category(s): Advanced Materials/Nanotechnology, Life Science (All LS Techs), Biomaterials, Chemical/Biological Sensors, Genomic Assays/Reagents/Tools
Tumor-Targeted Killing with Aptamer-Nucleic Acid Nanostructures
Despite decades of research, cancer remains one of today’s most pressing health concerns. Traditional treatment approaches such as radiation therapy and chemotherapy can cause systemic toxicity and become ineffective when resistant tumors emerge. Recently, anticancer strategies have focused on drugs which specifically target tumor-related biological...
Published: 10/7/2025   |   Inventor(s): Yung Chang, Hao Yan
Keywords(s): Bio-Technology, Drug Screening, Therapeutics
Category(s): Life Science (All LS Techs), Cancer Therapeutics, Genomic Assays/Reagents/Tools
Method of Simultaneous Frequency-Sweeping Lifetime Measurements on Multiple Excitation Wavelengths
A new lifetime imaging system that can fully measure the FRET network between five fluorescent labels in a single image scan has been developed at the University of Arizona. This technology is capable of performing hyper-dimensional lifetime imaging on multiple excitation wavelengths simultaneously, allowing for previously not achievable FRET imaging...
Published: 4/3/2023   |   Inventor(s): Leilei Peng, Ming Zhao
Keywords(s): fluorescence lifetime, frequency-sweeping
Category(s): Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Imaging & Optics > Microscopy, Spectroscopy, Polarimetry, Technology Classifications > Imaging & Optics
Porous Corrole Materials
Competitive Advantages A more efficient corrole-functionalized porous material Excellent catalyst performance High chemical stability Framework robustness within a wide range of pH values Summary USF inventors have developed novel corrole-based MOFs which possess a very rare (3,9)-c gfy network and feature 1D hexagonal mesoporous...
Published: 7/18/2023   |   Inventor(s): Shengqian Ma, Yanming Zhao
Keywords(s): Chemistry and Chemical Engineering, Materials
Category(s): Technology Classifications > Advance Materials
DNA Nanocaged Enzymes
Compartmentalization increases the overall activity and specificity of encapsulated enzymes by protecting the enzymes, maintaining a high concentration of enzymes and substrates, and promoting substrate channeling. While there have been artificial enzymatic particles that have been created using compartmentalization by virus-like proteins, liposomes,...
Published: 2/13/2025   |   Inventor(s): Jinglin Fu, Hao Yan, Neal Woodbury, Zhao Zhao
Keywords(s): Bioanalysis, Catalysis, Enzymes
Category(s): Advanced Materials/Nanotechnology, Bioanalytical Assays, Chemistries & Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors
DNA Nanocaged Enzymes
Compartmentalization increases the overall activity and specificity of encapsulated enzymes by protecting the enzymes, maintaining a high concentration of enzymes and substrates, and promoting substrate channeling. While there have been artificial enzymatic particles that have been created using compartmentalization by virus-like proteins, liposomes,...
Published: 2/13/2025   |   Inventor(s): Jinglin Fu, Hao Yan, Neal Woodbury, Zhao Zhao
Keywords(s): Bioanalysis, Catalysis, Enzymes
Category(s): Advanced Materials/Nanotechnology, Bioanalytical Assays, Chemistries & Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors
Infusion of Food Grade Coatings with Propylene Glycol into Ham Nets to Control Pest Infestations
Overview of Technology Food grade, sustainable coating formulations can be combined with nets to protect foods from pests during curing processes. Dry-cured ham is extremely susceptible to mold mite infestations during the aging process due to its moldy surface buildup and high fat and protein composition. Currently, Methyl bromide is the only fumigant...
Published: 6/10/2022   |   Inventor(s): Mark (Wes) Schilling, Yan Zhao, Yan Campbell, Thomas Phillips, Salehe Abbar, Barbara Amoah
Keywords(s): Food
Category(s): Agriculture & Food Science
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