Search Results - yanming+zhao

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Viral-Targeted Nanostructured Drug (VTND) Platform
The outbreak of COVID-19 and subsequent mutant variants has caused millions of deaths and severe acute respiratory illness worldwide. Therapeutics such as monoclonal antibodies, small molecule drugs inhibiting viral replication and immune modulators suppressing hyperinflammation have shown promise, but each comes with limitations including viral variant...
Published: 10/24/2024   |   Inventor(s): Hao Yan, Yang Xu, Deeksha Satyabola, Yize (Henry) Li, Abhay Prasad
Keywords(s):  
Category(s): COVID-19, SARS-CoV-2, Coronavirus, Advanced Materials/Nanotechnology, Life Science (All LS Techs), Pharmaceuticals, Non-Cancer Therapeutics
Label-Free Detection Platform for CircRNAs
Circular RNAs (circRNAs) hold great potential as novel biological and clinical biomarkers for diagnosis and prognosis of cancer and other diseases. Conventional detection techniques such as northern blotting, microarray, qRT-PCR and RNA-seq suffer from many issues including low sensitivity and background noise, which limit the use of circRNA in clinical...
Published: 1/19/2024   |   Inventor(s): Hao Yan, Yang Xu, Shaopeng Wang, Zijian Wan, Liangxiao Chen
Keywords(s):  
Category(s): Life Science (All LS Techs), Medical Diagnostics/Sensors, Imaging, Advanced Materials/Nanotechnology, Biomaterials, Bioanalytical Assays, Chemistries & Devices, Cancer
Structure Assisted Directed Evolution of Multivalent Ligands
Nanotechnology needs organization and precise control, which is why DNA self-assembly into nanostructures has been a remarkable breakthrough. The challenges in creating nanostructures and also the opportunities lie in how to achieve self-sustained replication. This allows for the system to amplify itself in unlimited cycles, which is not enabled in...
Published: 9/20/2024   |   Inventor(s): Hao Yan
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Genomic Assays/Reagents/Tools
DNA Gridiron
Self-assembling nucleic acid molecules have been utilized extensively for constructing unique nanoscale structures, and designing increasingly complex structures is a top nanotechnology challenge. Current methods to create NDA nanostructures are restricted to discrete domains of parallel lines as a result of the double crossover based unit motif, which...
Published: 4/14/2023   |   Inventor(s): Dongran Han, Hao Yan
Keywords(s): DNA nanotechnology
Category(s): Advanced Materials/Nanotechnology, Life Science (All LS Techs), Biomaterials, Chemical/Biological Sensors, Genomic Assays/Reagents/Tools
Tumor-Targeted Killing with Aptamer-Nucleic Acid Nanostructures
Despite decades of research, cancer remains one of today’s most pressing health concerns. Traditional treatment approaches such as radiation therapy and chemotherapy can cause systemic toxicity and become ineffective when resistant tumors emerge. Recently, anticancer strategies have focused on drugs which specifically target tumor-related biological...
Published: 4/14/2023   |   Inventor(s): Yung Chang, Hao Yan
Keywords(s): Bio-Technology, Drug Screening, Therapeutics
Category(s): Life Science (All LS Techs), Cancer Therapeutics, Genomic Assays/Reagents/Tools
Creation of Multivalent Aptamers to Target Effector T Cells to Attack Tumor Cells
Despite decades of research effort, cancer remains one of today’s most pressing health concerns. Present day treatment methods tend to include debilitating side effects mainly due to low specificity of the treatments. Recently, some attempts have been made to augment tumor immunity by using bi-specific, hybrid antibodies that direct immune cells...
Published: 4/14/2023   |   Inventor(s): Yung Chang, Hao Yan
Keywords(s):  
Category(s): Life Science (All LS Techs), Cancer Therapeutics, Genomic Assays/Reagents/Tools, Pharmaceuticals
Method of Simultaneous Frequency-Sweeping Lifetime Measurements on Multiple Excitation Wavelengths
A new lifetime imaging system that can fully measure the FRET network between five fluorescent labels in a single image scan has been developed at the University of Arizona. This technology is capable of performing hyper-dimensional lifetime imaging on multiple excitation wavelengths simultaneously, allowing for previously not achievable FRET imaging...
Published: 4/3/2023   |   Inventor(s): Leilei Peng, Ming Zhao
Keywords(s): fluorescence lifetime, frequency-sweeping
Category(s): Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Imaging & Optics > Microscopy, Spectroscopy, Polarimetry, Technology Classifications > Imaging & Optics
Porous Corrole Materials
Competitive Advantages A more efficient corrole-functionalized porous material Excellent catalyst performance High chemical stability Framework robustness within a wide range of pH values Summary USF inventors have developed novel corrole-based MOFs which possess a very rare (3,9)-c gfy network and feature 1D hexagonal mesoporous...
Published: 7/18/2023   |   Inventor(s): Shengqian Ma, Yanming Zhao
Keywords(s): Chemistry and Chemical Engineering, Materials
Category(s): Technology Classifications > Advance Materials
DNA Nanocaged Enzymes
Compartmentalization increases the overall activity and specificity of encapsulated enzymes by protecting the enzymes, maintaining a high concentration of enzymes and substrates, and promoting substrate channeling. While there have been artificial enzymatic particles that have been created using compartmentalization by virus-like proteins, liposomes,...
Published: 2/23/2023   |   Inventor(s): Jinglin Fu, Hao Yan, Neal Woodbury, Zhao Zhao
Keywords(s): Bioanalysis, Catalysis, Enzymes
Category(s): Advanced Materials/Nanotechnology, Bioanalytical Assays, Chemistries & Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors
DNA Nanocaged Enzymes
Compartmentalization increases the overall activity and specificity of encapsulated enzymes by protecting the enzymes, maintaining a high concentration of enzymes and substrates, and promoting substrate channeling. While there have been artificial enzymatic particles that have been created using compartmentalization by virus-like proteins, liposomes,...
Published: 2/23/2023   |   Inventor(s): Jinglin Fu, Hao Yan, Neal Woodbury, Zhao Zhao
Keywords(s): Bioanalysis, Catalysis, Enzymes
Category(s): Advanced Materials/Nanotechnology, Bioanalytical Assays, Chemistries & Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors
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