Search Results - yanming+zhao

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Structure Assisted Directed Evolution of Multivalent Ligands
Nanotechnology needs organization and precise control, which is why DNA self-assembly into nanostructures has been a remarkable breakthrough. The challenges in creating nanostructures and also the opportunities lie in how to achieve self-sustained replication. This allows for the system to amplify itself in unlimited cycles, which is not enabled in...
Published: 2/13/2025   |   Inventor(s): Hao Yan
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Genomic Assays/Reagents/Tools
DNA Gridiron
Self-assembling nucleic acid molecules have been utilized extensively for constructing unique nanoscale structures, and designing increasingly complex structures is a top nanotechnology challenge. Current methods to create NDA nanostructures are restricted to discrete domains of parallel lines as a result of the double crossover based unit motif, which...
Published: 2/13/2025   |   Inventor(s): Dongran Han, Hao Yan
Keywords(s): DNA nanotechnology
Category(s): Advanced Materials/Nanotechnology, Life Science (All LS Techs), Biomaterials, Chemical/Biological Sensors, Genomic Assays/Reagents/Tools
Tumor-Targeted Killing with Aptamer-Nucleic Acid Nanostructures
Despite decades of research, cancer remains one of today’s most pressing health concerns. Traditional treatment approaches such as radiation therapy and chemotherapy can cause systemic toxicity and become ineffective when resistant tumors emerge. Recently, anticancer strategies have focused on drugs which specifically target tumor-related biological...
Published: 2/13/2025   |   Inventor(s): Yung Chang, Hao Yan
Keywords(s): Bio-Technology, Drug Screening, Therapeutics
Category(s): Life Science (All LS Techs), Cancer Therapeutics, Genomic Assays/Reagents/Tools
Creation of Multivalent Aptamers to Target Effector T Cells to Attack Tumor Cells
Despite decades of research effort, cancer remains one of today’s most pressing health concerns. Present day treatment methods tend to include debilitating side effects mainly due to low specificity of the treatments. Recently, some attempts have been made to augment tumor immunity by using bi-specific, hybrid antibodies that direct immune cells...
Published: 2/13/2025   |   Inventor(s): Yung Chang, Hao Yan
Keywords(s):  
Category(s): Life Science (All LS Techs), Cancer Therapeutics, Genomic Assays/Reagents/Tools, Pharmaceuticals
Method of Simultaneous Frequency-Sweeping Lifetime Measurements on Multiple Excitation Wavelengths
A new lifetime imaging system that can fully measure the FRET network between five fluorescent labels in a single image scan has been developed at the University of Arizona. This technology is capable of performing hyper-dimensional lifetime imaging on multiple excitation wavelengths simultaneously, allowing for previously not achievable FRET imaging...
Published: 4/3/2023   |   Inventor(s): Leilei Peng, Ming Zhao
Keywords(s): fluorescence lifetime, frequency-sweeping
Category(s): Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Imaging & Optics > Microscopy, Spectroscopy, Polarimetry, Technology Classifications > Imaging & Optics
Porous Corrole Materials
Competitive Advantages A more efficient corrole-functionalized porous material Excellent catalyst performance High chemical stability Framework robustness within a wide range of pH values Summary USF inventors have developed novel corrole-based MOFs which possess a very rare (3,9)-c gfy network and feature 1D hexagonal mesoporous...
Published: 7/18/2023   |   Inventor(s): Shengqian Ma, Yanming Zhao
Keywords(s): Chemistry and Chemical Engineering, Materials
Category(s): Technology Classifications > Advance Materials
DNA Nanocaged Enzymes
Compartmentalization increases the overall activity and specificity of encapsulated enzymes by protecting the enzymes, maintaining a high concentration of enzymes and substrates, and promoting substrate channeling. While there have been artificial enzymatic particles that have been created using compartmentalization by virus-like proteins, liposomes,...
Published: 2/13/2025   |   Inventor(s): Jinglin Fu, Hao Yan, Neal Woodbury, Zhao Zhao
Keywords(s): Bioanalysis, Catalysis, Enzymes
Category(s): Advanced Materials/Nanotechnology, Bioanalytical Assays, Chemistries & Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors
DNA Nanocaged Enzymes
Compartmentalization increases the overall activity and specificity of encapsulated enzymes by protecting the enzymes, maintaining a high concentration of enzymes and substrates, and promoting substrate channeling. While there have been artificial enzymatic particles that have been created using compartmentalization by virus-like proteins, liposomes,...
Published: 2/13/2025   |   Inventor(s): Jinglin Fu, Hao Yan, Neal Woodbury, Zhao Zhao
Keywords(s): Bioanalysis, Catalysis, Enzymes
Category(s): Advanced Materials/Nanotechnology, Bioanalytical Assays, Chemistries & Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors
Infusion of Food Grade Coatings with Propylene Glycol into Ham Nets to Control Pest Infestations
Overview of Technology Food grade, sustainable coating formulations can be combined with nets to protect foods from pests during curing processes. Dry-cured ham is extremely susceptible to mold mite infestations during the aging process due to its moldy surface buildup and high fat and protein composition. Currently, Methyl bromide is the only fumigant...
Published: 6/10/2022   |   Inventor(s): Mark (Wes) Schilling, Yan Zhao, Yan Campbell, Thomas Phillips, Salehe Abbar, Barbara Amoah
Keywords(s): Food
Category(s): Agriculture & Food Science
Synbodies - High Throughput Development of Synthetic Antibodies
The development of new drugs and diagnostic assays requires the ability to identify and prepare high-affinity, high-specificity ligands. Monoclonal antibodies are useful reagents in this regard, but are difficult to humanize and express in large amounts. Monoclonal antibodies are also intrinsically limited by the immunological repertoire of the immunized...
Published: 2/13/2025   |   Inventor(s): Stephen Johnston, Neal Woodbury, John Chaput, Chris Diehnelt, Hao Yan
Keywords(s):  
Category(s): Life Science (All LS Techs), Diagnostic Assays/Devices, Bioanalytical Assays, Chemistries & Devices, Proteomic Assays/Reagents/Tools
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