Search Results - xianghui+he

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An Acoustic Device for Large Area Single Cell Trapping and Selective Release (Case No. 2025-047)

Summary: UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed an acoustic microfluidic platform that offers a cost-effective and practical approach for handling individual cells at the microscale. Background: Single-cell manipulation is essential for understanding cellular behavior, disease progression, and therapeutic...

Published: 7/23/2026 | Updated: 7/23/2026 | Inventor(s): Pei-Yu Chiou, Xiang Zhang

Keywords(s): acoustic microfluidics, acoustic potential wells, acoustics, cell proliferation, cell viability, Diagnostic Platform Technologies (E.G. Microfluidics), diagnostic platforms, Digital Microfluidics, disposable microfluidic platforms, high throughput, high throughput assays, high throughput testing, High-Content Screening, high-throughput cell handling, low-cost fabrication, MEMS, MEMS metasurface, micro-electromechanical systems (MEMS), Microfluidics, Microfluidics And Mem's, Microfluidics Dielectrophoresis, Microfluidics Multi-Band Device, Microfluidics Nanosphere, near-infrared laser, photolithography-free fabrication, research instrumentation, scalable platform, single cell analysis, single cell analysis and testing, Single cell data, single-cell handling, single-cell manipulation, single-cell resolution, single-cell trapping

Category(s): Chemical, Chemical > Chemical Processing & Manufacturing, Chemical > Instrumentation & Analysis, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Diagnostic Markers > Immunology, Diagnostic Markers > Cancer, Life Science Research Tools, Life Science Research Tools > Lab Equipment, Life Science Research Tools > Microfluidics And Mems, Life Science Research Tools > Research Methods, Mechanical, Mechanical > Instrumentation, Platforms, Platforms > Diagnostic Platform Technologies

Summary: UCLA researchers have developed a webcam-based eye-tracking tool for Qualtrics online surveys that verifies human presence and participation during survey completion, while also allowing researchers to collect eye-tracking data without specialized hardware. Background: Online survey research is facing growing data integrity problems as AI...

Published: 7/21/2026 | Updated: 7/21/2026 | Inventor(s): Ian Krajbich, Kianté Fernandez, Stephanie Smith, Xiaozhi Yang

Keywords(s):

Category(s): Software & Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Programs, Software & Algorithms > Data Analytics, Software & Algorithms > Digital Health

Modulation and Utility of DCAF10-associated CRL4 Ubiquitin Ligase Complexes Targeting Proteins for Proteolysis

This technology utilizes the CRL4-DCAF10 ubiquitin ligase complex to target and tag specific proteins for proteasomal degradation. By using chemical inhibitors and engineered PROTAC molecules, the system recruits target proteins to catalyze their destruction and control cellular protein levels. This mechanism provides a powerful platform for drug discovery...

Published: 7/17/2026 | Updated: 7/17/2026 | Inventor(s): Hui Zhang

Keywords(s):

Category(s): Technology Classifications > Therapeutics, Pharmaceuticals, Drug Delivery, Technology Classifications > Chemistry

SIGMA DELTA QUANTIZATION FOR IMAGES

VAlue proposition The value proposition of this technology lies in its innovative approach to image quantization using Sigma Delta quantization. By segmenting pixel values into columns and quantizing each column as a whole using Sigma Delta modulation, the technique minimizes accumulated quantization error, thereby enhancing the reconstruction quality...

Published: 6/27/2026 | Updated: 6/27/2026 | Inventor(s): Rongrong Wang, He Lyu

Keywords(s):

Category(s): Computer Software

clampFISH 2.0: Fast, Cost-Effective RNA Detection Using Potent Fluorescent Probes

Molecular diagnostic using clamping fluorescent probes to amplify RNA detection signal of single-cell assay Problem: The molecular diagnostics market is expected to reach $13 billion by 2024, including cancer detection, blood screening, histology assays, tests for transplant compatibility, and inherited and infectious diseases (The World Market for...

Published: 6/29/2026 | Updated: 6/26/2026 | Inventor(s): Arjun Raj, Ian Dardani, Benjamin Emert, Sara Rouhanifard

Keywords(s): Bioengineering, Infectious Disease, Nanotechnology, Oncology

Category(s): Technology Classifications > Research Tools & Reagents, Technology Classifications > Diagnostics

Systems and Methods for Concurrent Biochemical Immunoassay and Cellular Traction Force Measurement in Hydrogels

This invention relates to a platform that couples bead-based immunoassays with 3D traction force microscopy (TFM) within a single hydrogel substrate to quantify time-resolved biochemical cues and cell-generated mechanical forces at matched locations. This invention allows researchers to directly test how local molecular cues influence cell mechanics...

Published: 6/17/2026 | Updated: 3/23/2026 | Inventor(s): Alex McGhee, Kelvin Pond, A Departmental Work

Keywords(s):

Category(s): Technology Classifications > Imaging & Optics > Sensors and Detection, Technology Classifications > Engineering & Physical Sciences > Photonics, Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Research Tools > Screening assays

Polymerase-Theta Inhibition for Treating Epstein-Barr Virus (EBV) Cancers and Related Diseases

Proteolysis Targeting Chimeras (PROTACs) Block Microhomology or Theta-Mediated End Joining in Cancer Cells These polymerase theta inhibitors treat Epstein-Barr virus (EBV)-associated cancers and related diseases. EBV cancers are linked to two percent of the global cancer burden and are difficult to treat, demonstrating a strong need for effective...

Published: 4/13/2026 | Updated: 3/18/2026 | Inventor(s): Sumita Bhaduri-McIntosh, Michael McIntosh, Guangrong Zheng, Hui Chen

Keywords(s):

Category(s): Technology Classifications > Human Health Care > Therapeutics

Fully Wearable Band for Long-Term Peripheral Ultrasound Neuromodulation in Pain Management

Wearable ultrasound neuromodulation device for peripheral nerve pain relief A wearable ultrasound armband uses a focused piezoelectric transducer and acoustic hydrogel to deliver low-intensity ultrasound pulses to peripheral nerves, noninvasively reducing chronic and neuropathic pain for several hours. Background Peripheral nerve stimulation has...

Published: 3/11/2026 | Updated: 3/11/2026 | Inventor(s): Huiliang Wang, William Barrera, Jinmo Jeong, Thomas Wynn, Xiang Qian, QiLiang Chen, Yaoyao Jia, Yiming Han

Keywords(s):

Category(s): Life sciences > Medical technology > Medical devices

Student Outcomes & Predictions in Higher Education using Artificial Intelligence (SOPHEA-I )

RPI ID: 2021-021-401 Innovation Summary: A predictive analytics system uses student data to forecast retention rates across academic programs. The model incorporates behavioral, demographic, and performance metrics to identify at-risk students. Machine learning algorithms continuously refine predictions based on new inputs. The system supports institutional...

Published: 3/10/2026 | Updated: 3/10/2026 | Inventor(s): Jasmine Yang, Lu Enzhe, Jiarun Li, Yihui Yang, Hui Su, Yifan Liu, Keith Moo-Young

Keywords(s): AI, machine-learning, Student Persistent and success

Category(s): Media, Arts, Science and Technology

Ultrasound-triggered anesthetic drug delivery for on-demand chronic pain management

A nanoparticle-based ultrasound-responsive drug delivery system for precise, controlled, and targeted therapeutic release This technology uses ultrasound-triggered nanoparticles to deliver local anesthetics precisely and safely for pain management, reducing side effects and opioid risks, with potential for targeted delivery of other drugs in cancer,...

Published: 3/10/2026 | Updated: 2/17/2026 | Inventor(s): Huiliang Wang, Weilong He, Xi Shi, George Bittner, Cathy Yang, Yanxing Wang, Wenliang Wang, Pengyu Ren

Keywords(s):

Category(s): Life sciences > Medical technology > Medical devices

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