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Interactive Systems and Methods for Identifying Target Proteins in Drug Discovery (Case No. 2025-098)

Summary: UCLA researchers from the Department of Electrical and Computer Engineering have developed a novel computational system for target protein identification, enabling integrative drug discovery. Background: Target identification (Target ID) in drug discovery involves the identification and evaluation of protein candidates that could interact...

Published: 10/1/2025 | Inventor(s): Xiang Chen, Youngseung Jeon, Christopher Hwang, Ziwen Li, Jesus Campagna, Varghese John, Whitaker Cohn, Eunice Jun

Keywords(s): AI-driven drug discovery, Alzheimer’s disease target discovery, Bioinformatics software platform, Drug, Drug Discovery, Functional annotation of proteins, High-throughput docking, large language models (LLMs), Ligand-protein docking, Mechanism-of-action prediction, Molecular docking simulation, Multi-criteria decision support, Neurodegenerative disease therapeutics, Pathway-centric drug targeting, personalized medicine, PPI-Comparator, PPI-Explorer, Protein structure prediction, Protein-protein interaction (PPI) analysis, Rational drug design, Retrieval-augmented generation (RAG), Semantic similarity modeling, Small molecule screening, Systems biology interface, Target identification (Target ID), Therapeutic impact modeling, User-guided AI exploration

Switchable Magnetic Device Holder

The Problem: The prolific use of mobile devices has driven demand for secure, convenient mounting solutions across various environments. Traditional docking stations often rely on adhesive pads and mechanical clamps can be bulky, not universally compatible, and difficult to operate with one hand. Suction based holders are prone to stability issues....

Published: 8/4/2025 | Inventor(s): Greg Berkeley, Ian Shen

Keywords(s):

Category(s): Technology Classifications, Technology Classifications > Lifestyle & Leisure

Methods and Systems for Low-Cost Medical Image Annotation Using Non-experts (Case No. 2025-108)

Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed an AI-based interface designed to enable individuals without specialized training to identify arthritis in medical imaging. Background: The use of artificial intelligence (AI) for medical imaging analysis holds great promise for the future of healthcare....

Published: 10/24/2025 | Inventor(s): Xiang Chen, Youngseung Jeon, Christopher Hwang

Keywords(s): 3D tissue imaging, AI-guided diagnostics, AI-guided medical imaging, AI-guided medical intervention, arthritis, Artifical Intelligence (Machine Learning, Data Mining), Artificial Intelligence, artificial intelligence algorithms, artificial intelligence augmentation, artificial intelligence/machine learning models, Artificial Neural Network, bioimaging, Computer-Aided Diagnosis, computer-aided radiology, Diagnostic Markers & Platforms, Diagnostic Test, diagnostics, generative artificial intelligence, Image Analysis, Image Resolution, Imaging, infrared thermal imaging, Machine Learning, machine learning modeling, machine perception, Magnetic Resonance Imaging Medical Physics, Magnetic Resonance Imaging Pathology, Medical artificial intelligence (AI), Medical diagnostics, Medical Imaging, Microscopy And Imaging, non-invasive imaging, osteoarthritis, radial MRI, radiologic imaging, Radiology, Radiology / Radiomitigation, radiosurgery

Category(s): Software & Algorithms, Software & Algorithms > AI Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Digital Health, Software & Algorithms > Image Processing, Life Science Research Tools, Life Science Research Tools > Lab Equipment, Life Science Research Tools > Microscopy And Imaging, Medical Devices, Medical Devices > Medical Imaging, Medical Devices > Monitoring And Recording Systems, Therapeutics, Therapeutics > Musculoskeletal Disease, Therapeutics > Radiology

Batch Processing Automation for Imaris Stitcher (Case No. 2025-089)

Summary: Researchers in UCLA’s Department of Neurobiology have developed a novel software tool that enhances the capabilities of Imaris Stitcher. The tool enables batch processing and automated execution of multiple image stitching jobs, significantly improving workflow efficiency and reducing hands-on time. This results in readily available,...

Published: 7/14/2025 | Inventor(s): Ian Bowman, Mitchell Rudd, Hong Wei Dong

Keywords(s): 3D tissue imaging, 3D ultrasound imaging, Artifical Intelligence (Machine Learning, Data Mining), Artificial Intelligence, artificial intelligence algorithms, artificial intelligence augmentation, artificial intelligence/machine learning models, artificial-intelligent materials, bioimaging, Cell Counting/Imaging, cell imaging, cell mapping, computational imaging, Data Acquisition, Data Aggregator, Data Analytics, Data Recovery, Data Structure, Fluorescence Microscope, histopathology images, Image Analysis, image restoration, image signal processing, Imaging, Magnetic Resonance Imaging, Medical artificial intelligence (AI), Medical Imaging, Microscope, Microscopy, Microscopy And Imaging, Molecular Imaging, multi-contrast imaging, Neuroimaging, non-invasive imaging, pathology image analysis, Phase-Contrast Imaging, three dimensional imaging, volumetric image

Category(s): Software & Algorithms, Software & Algorithms > AI Algorithms, Software & Algorithms > Digital Health, Software & Algorithms > Image Processing

PET Imaging Agents for Fungal Infections

Available for licensing and commercial development are patent rights covering PET imaging agents, methods of their synthesis, and their uses in imaging specific fungal infections. Fungal infections remain a global health problem resulting in over 1.5 million annual deaths. Immunocompromised patients, especially those undergoing cancer treatments or...

Published: 8/13/2025 | Inventor(s): Dima Hammoud, Swati Shah, Peter Williamson, Rolf Swenson, Xiang Zhang, Falguni Bhattacharyya

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Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Collaboration Sought > Licensing

Methods and Sequences for mRNA and Other HIV Vaccine Development

Unique sequences eliciting broadly neutralizing antibodies (bNAbs) against human immunodeficiency virus (HIV) that could be used to develop effective mRNA-based and other types of HIV vaccine. Problem: Despite decades of research, there is currently no vaccine to prevent HIV infection. A major goal of HIV vaccine programs is to generate bNAbs, which...

Published: 8/1/2025 | Inventor(s): George Shaw, Edward (Ted) Kreider, Beatrice Hahn, Ashwin Skelly, Hui Li, Drew Weissman

Keywords(s): Bioengineering, HIV/AIDS, Immunology, Infectious Disease, Protein/Peptide (Non-Antibody)

Category(s): Technology Classifications > Vaccines

IRF4-Engineered T Cells Induce T Cell Function As a Treatment Strategy for Solid Tumors

Asset/Technology Type New Therapeutic Strategy Description of Invention The invention includes compositions and methods of delivering therapeutic anti-tumor T cells by forcing them to overexpress interferon regulatory factor (IRF4) as a treatment for various solid tumors, including but not limited to melanoma, lymphoma, and colon cancer. The inventors...

Published: 5/21/2025 | Inventor(s): Wenhao Chen, Xian Li

Keywords(s):

Category(s): Clinical Area > Transplantation, Clinical Area > Cancer, Clinical Area > Metabolic Disease, Inflammation, and Immunology, Research Area > Cancer, Research Area > Immunobiology and Inflammation, Technology Classifications > Therapeutic > Cell and Gene Therapies

Sensitive Point-of-Care miRNA Detection Using a One-Pot, Isothermal Assay

Rapid, RNA Extraction-Free Detection of miRNAs Biomarkers for Accurate Cancer Diagnosis and Prognosis This CRISPR-Cas12a-based assay allows for the rapid, sensitive detection of microRNAs using a one-pot, isothermal process. MicroRNAs(miRNAs) are endogenous and short, non-coding single-stranded RNAs. They participate in various biological functions...

Published: 5/30/2025 | Inventor(s): Yong Zeng, He Yan

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Category(s): Technology Classifications > Human Health Care > Diagnostics, Technology Classifications > Veterinary > Diagnostics

Acquisition – Software to Control Acquisition of Images for Near-Earth Object Survey Operations

The Acquisition subsystem in the Catalina Sky Survey (CSS) software suite manages the operation of telescopes and instruments to capture data on asteroids and Near-Earth Objects (NEOs). Once areas of the sky are selected for observation, Acquisition takes over, accepting the input from the Planner subsystem and coordinating the telescope, camera, and...

Published: 12/9/2024 | Inventor(s): A Departmental Work

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Category(s): Technology Classifications > Software & Information Technology > Open Source, Technology Classifications > Software & Information Technology

Planner – Planning Software for Near-Earth Object Survey Operations

The Planner subsystem in the Catalina Sky Survey (CSS) software suite is designed to help observers efficiently plan nightly asteroid and Near-Earth Object (NEO) observations. By displaying a virtual map of the sky, it helps ensure that areas previously searched, or areas unlikely to be productive, are avoided. The map shows the telescope’s current...

Published: 12/9/2024 | Inventor(s): A Departmental Work

Keywords(s):

Category(s): Technology Classifications > Software & Information Technology > Open Source, Technology Classifications > Software & Information Technology

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