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Search Results - weilong+he
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Language-Agnostic Voice Biomarker Platform for Early Detection of Alzheimer’s Disease and Related Dementias (GloVoAD)
This technology enables early, non-invasive detection of Alzheimer’s disease and related dementias using a large-scale multilingual voice dataset and language-agnostic AI models that analyze vocal biomarkers without relying on speech transcription. BACKGROUND: Early detection of Alzheimer’s disease and related dementias (ADRD) remains...
Published: 4/9/2026
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Updated: 4/8/2026
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Inventor(s):
Wei Bo
,
Wenyao Xu
,
Aditya Challamarad
,
Harry Lin
Keywords(s):
Technologies
Category(s):
Campus > University at Buffalo
,
Technology Classifications > Artificial Intelligence
,
Technology Classifications > Diagnostics
Beamforming Device and Architectures for Large Language Model Enabled Personal Monitoring
WisperWatcher is a wearable audio-based system that automatically monitors eating behavior by capturing and analyzing mastication and swallowing sounds. Leveraging beamforming techniques combined with Large Audio-Language Models (LALM), it provides accurate, real-time insights into food intake, meal timing, and user disposition while minimizing user...
Published: 4/10/2026
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Updated: 3/17/2026
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Inventor(s):
Alexander Gherardi
,
Wenyao Xu
,
Wei Bo
,
Shuwei Hou
Keywords(s):
Technologies
Category(s):
Campus > University at Buffalo
,
Technology Classifications > Artificial Intelligence
,
Technology Classifications > Medical Devices
Small-Molecule IL-6 Inhibitors Targeting gp130 for Anti-Cancer Therapy
Blocks IL-6-gp130 Signaling for Cost-Effective Treatment of Autoimmune Diseases and IL-6–Driven Cancers These small-molecule interleukin-6 (IL-6) inhibitors target glycoprotein 130 (gp130) by blocking IL-6-gp130 signaling, delivering a cost-effective therapy for autoimmune diseases and IL-6-driven cancers. IL-6-gp130 signaling drives tumor growth...
Published: 3/31/2026
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Updated: 3/2/2026
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Inventor(s):
Chenglong Li
,
Liguang Mao
,
Daniel Schultz
,
Zhihang Shen
,
Xiaozhi Yang
,
Wei Zhou
Keywords(s):
Category(s):
Technology Classifications > Human Health Care > Therapeutics
Ultrasound-triggered anesthetic drug delivery for on-demand chronic pain management
A nanoparticle-based ultrasound-responsive drug delivery system for precise, controlled, and targeted therapeutic release This technology uses ultrasound-triggered nanoparticles to deliver local anesthetics precisely and safely for pain management, reducing side effects and opioid risks, with potential for targeted delivery of other drugs in cancer,...
Published: 3/10/2026
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Updated: 2/17/2026
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Inventor(s):
Huiliang Wang
,
Weilong He
,
Xi Shi
,
George Bittner
,
Cathy Yang
,
Yanxing Wang
,
Wenliang Wang
,
Pengyu Ren
Keywords(s):
Category(s):
Life sciences > Medical technology > Medical devices
Efficient Genome Editing Tool Using CODE Systems for Precise Modifications
Complements Existing Prime Editors to Expand Toolbox for Genome Manipulations This precision-driven genome editing tool uses chimeric oligonucleotide-directed editing (CODE) to replace, insert, or delete specific genes with exceptional accuracy. The genome editing market, valued at nearly $10 billion in 2024 and anticipated to grow to $25 billion by...
Published: 2/4/2026
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Updated: 10/9/2025
|
Inventor(s):
Piyush Jain
,
Noah Rakestraw
,
Briana Pizzano
,
Cameron Myhrvold
,
Long Nguyen
Keywords(s):
Category(s):
Technology Classifications > Human Health Care > Therapeutics
,
Technology Classifications > Research Tools > Therapeutics
Reagents Targeting Neurodegenerative Diseases and Traumatic Brain Injury
Misfolding and aggregation of proteins, such as beta-amyloid (Aß), alpha-synuclein (a-syn), tau and TAR DNA-binding protein 43 (TDP-43), have been strongly correlated with early onset of neurodegenerative diseases such as Alzheimer's Disease (AD), Parkinson's Disease (PD), Frontotemporal Dementia (FTD), amyotrophic lateral sclerosis (ALS) and...
Published: 2/26/2026
|
Updated: 8/27/2025
|
Inventor(s):
Michael Sierks
,
Lalitha Venkataraman
,
Wei Xin
Keywords(s):
Alzheimer's Disease
,
CNS Therapeutics
,
Dementias
,
Neurodegenerative Disorders
,
Neurological Disorders
,
Phage display
Category(s):
Bioanalytical Assays, Chemistries & Devices
,
Diagnostic Assays/Devices
,
Life Science (All LS Techs)
,
Neurodegenerative Disease Technologies
,
Non-Cancer Therapeutics
,
Proteomic Assays/Reagents/Tools
SECURE BIOMETRIC RECOGNITION USING EFFICIENT NEURAL NETWORKS
Value proposition Face Recognition (FR) has become integral to identity management in many practical applications, from unlocking personal devices to facilitating law enforcement and accessing financial services. These systems process sensitive biometric data that, if compromised, can lead to privacy invasions, identity theft, and unauthorized surveillance....
Published: 3/31/2026
|
Updated: 8/19/2025
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Inventor(s):
Vishnu Boddeti
,
Wei Ao
Keywords(s):
Category(s):
Computer Software
,
Informatics
,
Data Processing/Analysis
Reducing Ischemic Kidney Injury Through Synchronization Modulation Electric Field (SMEF)
Advantages SMEF enables ATP regeneration under ischemic conditions Non-invasive, broad-spectrum applicability to multiple cell and tissue types Enhances organ viability during transplantation Broad Applicability: mechanism is relevant to other ischemic injuries (e.g., heart, brain, liver), opening doors to multi-organ applications Summary Kidney...
Published: 8/8/2025
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Updated: 8/8/2025
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Inventor(s):
Wei Chen
,
Ruisheng Liu
Keywords(s):
Organ Transplantation
,
Renal / Kidney
Category(s):
Technology Classifications > Medical > Cell & Tissue Engineering
Just-In-Time Analytics on Large File and Storage Systems
Traditional file systems, such as NTFS and ext3, often struggle to support complex analytics due to limited metadata and the absence of global views. Performing aggregate or top-k queries typically requires exhaustive scanning or pre-built indexes, which are time-consuming and resource-intensive. These limitations hinder efficient data management and...
Published: 1/9/2026
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Updated: 8/6/2025
|
Inventor(s):
Hao (Howie) Huang
,
Nan Zhang
,
Gautam Das
,
Alexander Szalay
,
Wei Wang
Keywords(s):
Category(s):
Technology Classifications > Computers Electronics & Software > Computing Architecture
,
Technology Classifications > Computers Electronics & Software > Databases
Chip-based Nano-optoelectrodes for Optical Voltage Sensing
THE CHALLENGE The challenge in developing reliable, scalable optical voltage sensors lies at the intersection of technical complexity and commercial viability. Current solutions—ranging from fluorescent dyes to random plasmonic nanostructures—face critical limitations: they either require invasive labeling, suffer from photobleaching,...
Published: 10/22/2025
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Updated: 7/3/2025
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Inventor(s):
Yuming Zhao
,
Chuan Xiao
,
Wei Zhou
Keywords(s):
Category(s):
Technology Classifications > Electronics
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