Search Results - jean+bennett

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Problem: Optic neuritis is a condition commonly observed in MS patients that leads to temporary or permanent visual decline following demyelination of the optic nerve and loss of retinal ganglion cells. Current therapies for MS and ON include immunosuppressive agents that mitigate the inflammatory component of disease. Unfortunately, these treatments...

Published: 5/14/2026 | Updated: 5/14/2026 | Inventor(s): Kenneth Shindler, Devin McDougald, Junwei Sun, Jean Bennett

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Category(s): Technology Classifications > Therapeutics

PennSorter: A software platform for rapid neural signal analysis.

PennSorter is a specialized "spike-sorting" software designed to facilitate the precise assignment of electrical signals to cells with enhanced accuracy and efficiency. Problem: Biomedical researchers, particularly those studying neurons and other electrically excitable cells like cardiac or muscle cells, frequently gather electrical data...

Published: 9/8/2025 | Updated: 10/9/2023 | Inventor(s): William Beltran, Sergei Nikonov, Jean Bennett, Roman Nikonov, Puya Aravand

Keywords(s): Neurology, Software

Category(s): Technology Classifications > Research Tools & Reagents

Versatile virtual reality system for functional vision evaluation

Virtual reality-based system and software for quick, accurate, and reproducible evaluation of functional vision capacity following clinical treatment Problem: In 2013, the total economic burden of eye disorders and vision loss in the United States was $139 billion with projections to increase by ~20% over the following 10 years. Developing treatments...

Published: 8/6/2025 | Updated: 11/9/2021 | Inventor(s): Jean Bennett, Tomas Aleman, Manzar Ashtari, Alexander Miller, Albert Maguire, Nancy Bennett

Keywords(s): Augmented Reality (AR) & Virtual Reality (VR), Gene Therapy, Genetic Disorders, Ophthalmology

Category(s): Technology Classifications > Diagnostics

Gene Therapy for Achromatopsia

Problem: There currently is no cure for Achromatopsia which affects up to 1: 50,000 patients in the US. Solution: Dr. Jean Bennett, MD, PhD, Kirby Professor of Ophthalmology at the University of Pennsylvania’s Perelman School of Medicine, one of the first investigators to develop a gene therapy for a rare inherited form of retinal blindness...

Published: 6/28/2024 | Updated: 4/1/2020 | Inventor(s): Jean Bennett, Jeannette Bennicelli, Junwei Sun

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Category(s): Technology Classifications > Therapeutics

Enhanced Gene Transfer for Retinal Therapies

Technology Overview: While Adeno-Associated Viruses (AAVs) shows great promise in gene therapy applications for the treatment of inherited and acquired retinal diseases, a significant challenge to date has been the limitation of AAV vectors to transduce non-permissive retinal cells and to express in a single cell type. The inventors have generated...

Published: 6/28/2024 | Updated: 3/20/2020 | Inventor(s): Jean Bennett

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Category(s): Technology Classifications > Therapeutics