Search Results - william+figg

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Cancer Therapeutic Based on Hypoxia Inducible Factor 1 (HIF-1) Inhibitors
Abstract: Hypoxia is a characteristic of many solid tumors resulting from accelerated cellular proliferation and inadequate vascularization. HIF-1 is a transcription factor critical for maintaining cellular homeostasis in, and adaptively responding to, low oxygen environments. HIF-1 becomes activated through binding to the transcriptional co-activator...
Published: 4/8/2024   |   Inventor(s): Kirk Gustafson, Martin Schnermann, Susanna Chan, Paresma Patel, William Figg, James McMahon
Keywords(s): CANCER, Hypoxia Inhibitor, Malaria, small molecule
Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics
Natural product-based anti-cancer agents: aza-Englerin analogues
Abstract: Chemotherapy resistance in a wide array of cancers is often associated with enhanced glucose uptake and dysregulation of the insulin signaling pathway.  Therapeutics capable of inhibiting insulin signaling would be valuable as a stand-alone treatment and for sensitizing resistant tumors to standard chemotherapy regiments.  Researchers at NCI’s...
Published: 7/3/2024   |   Inventor(s): Willaim Chain, John Beutler, William Figg, Joe Ramos, Florian Suizmaier, Zhenwu Li, Daniel Fash, Ian Talisman, Cody Peer
Keywords(s): Ewing, Glycolytic, insulin, Resistance, Sarcoma
Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology
SLCO1B3 Genotyping to Predict a Survival Prognosis of Prostate Cancer
Abstract: Steroid hormones have been implicated to play a fundamental role in the pathogenesis of prostate cancer. Polymorphisms in the genes that code for enzymes, or hormones involved in androgen regulatory pathway, reportedly influence risk for developing prostate cancer. Since many membrane transporters are modulators of steroid hormones absorption...
Published: 4/8/2024   |   Inventor(s): William Figg, Alex Sparreboom, Douglas Price, Akinobu Hamada
Keywords(s): Androgen-directed Therapy, Biomarkers, diagnostic, Figg, genetic markers, Genomics, Hormone-Refractory, personalized medicine, predictive markers, prognostic, PROSTATE, SLCO1B3
Category(s): TherapeuticArea > Endocrinology, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Diagnostics, TherapeuticArea > Oncology
Aryl Hydantoin Heterocycle Compounds that Target the Androgen Receptor for Prostate Cancer Treatment
Abstract: Prostate cancer is the most prevalent form of cancer among all men in the United States (US). It is also the second leading cause of cancer-related deaths in the US among men, largely due to the progressively treatment resistant nature of the disease. Treatment options for early stage prostate cancer include watchful waiting, radical prostatectomy,...
Published: 4/8/2024   |   Inventor(s): Berkley Gryder, Adegboyega Oyelere, Eric Raftery, Subhasish Tapadar, Nicholas Aboreden, William Figg
Keywords(s): Androgen Deficiency Disorders, Androgen dysfunctional Disorders, Androgen Receptor, Androgen Receptor Inverse Agonists, Anti-androgens, AR, ARIA, BREAST CANCER, Georgia Institute of Technology, GIT, Gryder, Hyperandrogenism, PROSTATE CANCER
Category(s): Application > Therapeutics, TherapeuticArea > Endocrinology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology
Thalidomide Analogs that Inhibit Inflammation and Angiogenesis
Abstract: Thalidomide and its close analogs (lenalidomide and pomalidomide) are widely used to treat a variety of diseases, such as multiple myeloma and other cancers as well as the symptoms of several inflammatory disorders. However, thalidomide is known for its teratogenic adverse effects when first clinically introduced in the 1950s, and is associated...
Published: 4/8/2024   |   Inventor(s): Nigel Greig, Weiming Luo, David Tweedie, Nell Vargesson, Shaunna Beedle, William Figg
Keywords(s): anti-angiogenesis, ANTI-INFLAMMATORY, Lenalidomide, Pomalidomide, THALIDOMIDE
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics
PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids
The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...
Published: 7/30/2024   |   Inventor(s): Payman Dehghanian, Shiyuan Wang, Li Li
Keywords(s):  
Category(s): Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment
Distributed Feedback Fiber Laser Pumped by Multimode Diode Lasers
Researchers at the University of Arizona College of Optical Sciences and Canada's Carleton University recently succeeded in fabricating high reflectivity (>99%) Fiber Bragg Gratings (FBGs) into phosphate glass fibers using UV light and a phase mask technique. With this new manufacturing technique, fiber lasers can be created as single monolithic...
Published: 4/3/2023   |   Inventor(s): Nasser Peyghambarian, Axel Schülzgen, Li Li, Jacques Albert
Keywords(s):  
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Lasers & Other Sources
All-Fiber Multicore Fiber Laser Devices
Researchers at the University of Arizona have developed a compact, power-scalable, alignment-free fiber laser that takes a new approach to stabilizing phase-locked operation of multi-core fiber lasers by completely removing all free space optical components. This high-brightness, all-fiber laser package uses passive optical fiber spliced at both ends...
Published: 4/3/2023   |   Inventor(s): Nasser Peyghambarian, Axel Schülzgen, Li Li
Keywords(s):  
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Fiber Optics, Technology Classifications > Imaging & Optics > Lasers & Other Sources