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Replication System, Novel Polymerases, and Uses for Threose Nucleic Acid
Synthetic genomics, though a relatively nascent field, is generating a lot of excitement in the scientific community, especially with the advent of unnatural nucleic acid polymers. Threose nucleic acid (TNA) is one such unnatural nucleic acid polymer that is particularly promising because of its high resistance to nuclease degradation, making it much...
Published: 8/27/2025   |   Inventor(s): John Chaput, Matthew Dunn
Keywords(s): Synthetic Polymerases
Category(s): Cancer Therapeutics, Diagnostic Assays/Devices, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Non-Cancer Therapeutics
Intracellular DNA Barcoding Method for Single-Cell Amplification and Sequencing
Studying single cells is difficult due to the laborious and costly cell isolation procedures which restrict throughput and impede the analysis of large numbers of cells or multiple samples in a single experiment. ASU researchers previously developed a method which used the cell’s membrane as a container for different reactions. One such reaction...
Published: 8/19/2025   |   Inventor(s): Kerry Geiler-Samerotte, Kara Schmidlin, Leandra Brettner, Parker Crossland
Keywords(s):  
Category(s): Bioanalytical Assays, Chemistries & Devices, Chemical/Biological Sensors, Diagnostic Assays/Devices, Genomic Assays/Reagents/Tools, Life Science (All LS Techs)
Massively Parallel Method to Quantify Protein Folding & Stability
Protein misfolding plays a role in degenerative diseases, cancer evolution, synthetic biology, bioproducts, and more. Despite its importance in all of these fields, researchers often struggle to understand even the basic mechanisms of protein misfolding. For example, there is no tool to determine how much misfolding is happening inside of any given...
Published: 8/19/2025   |   Inventor(s): Yuichi Eguchi, Kerry Geiler-Samerotte
Keywords(s):  
Category(s): Life Science (All LS Techs), Genomic Assays/Reagents/Tools, Proteomic Assays/Reagents/Tools, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Medical Diagnostics/Sensors
Nucleic Acid-Triggered Gated Pore Formation for Sensing and Signal Amplification
Cells have developed various means for transporting molecules across membranes as well as cellular compartments separated by membranes. Channels and pores can be formed with different protein assemblies to enable the regulated passage of molecules in and out of cells, which has led to them being exploited as molecular sensors for characterizing biomolecules...
Published: 6/23/2025   |   Inventor(s): Rizal Hariadi, Ranjan Sasmal
Keywords(s):  
Category(s): Biological Nanotechnology, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Bioanalytical Assays, Chemistries & Devices
System and Circuit of Compute-in-Memory Design for Genome Alignment
Next-generation sequencing (NGS) technologies have revolutionized genomics research because they enable faster, cheaper and accurate decoding of nucleotide sequences. This has resulted in breakthroughs in diagnostics, disease risk assessment, personalized medicines, screening and more. However, despite all the NGS-related advancements that have been...
Published: 5/1/2025   |   Inventor(s): Deliang Fan, Fan Zhang
Keywords(s): Bio-Technology, Computational Machine, Computing Architecture, Gene, Memory, Personalized medicine
Category(s): Artificial Intelligence/Machine Learning, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Manufacturing/Construction/Mechanical, Semiconductor Devices, Semiconductors, Materials & Processes
DNA/RNA Origami Assembly Mediated by Functional Peptides
DNA and RNA nanostructures, e.g., DNA Origami, have great potential in biological applications, including extracellular matrix scaffolds and delivery vehicles for drugs and gene therapies. While folding DNA origami under physiological conditions is plausible, significant challenges and limitations remain. For example, isothermal annealing of DNA origami...
Published: 4/2/2025   |   Inventor(s): Di Liu, Bing Xu, Zhishang Li, Jiaqi Guo
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Biological Nanotechnology, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Manufacturing/Construction/Mechanical, Nucleic Acid/Peptide/Protein Therapies
RNA Sensor Platform for Targeting Cancer Fusion Genes and Transcripts
Many cancers have recurrent chromosomal translocations leading to the fusion of two genes. Often, said cancers are aggressive, have a poor prognosis with metastasis or recurrence, and do not have effective and targeted treatment. The challenge of many fusion-positive cancers is the lack of established targets downstream of the gene fusion despite years...
Published: 7/21/2025   |   Inventor(s): Albert Cheng, Ching Lau, Nathaniel Jilette, Jacqueline Jufen Zhu
Keywords(s):  
Category(s): Cancer, Cancer Therapeutics, Chemical/Biological Sensors, Genomic Assays/Reagents/Tools, Life Science (All LS Techs)
DNA Sequencing by Molecular Recognition and Nanoscale Manipulation of Single Molecules
The US Government's pursuit of the "Thousand Dollar Genome" and the "X Prize" goal of even lower cost DNA sequencing are striking examples of the importance being assigned to advances in methods for the DNA sequencing of the human genome. The first technology that finally allows for truly routine genome sequencing will open a new...
Published: 2/13/2025   |   Inventor(s): Stuart Lindsay, Jin He, Peiming Zhang, Kevin Reinhart
Keywords(s):  
Category(s): Life Science (All LS Techs), Bioanalytical Assays, Chemistries & Devices, Genomic Assays/Reagents/Tools
DNA Sequencing and Mutation Rate Estimation
DNA mutations are the basis of all heritable biological variation. Some variation gives rise to beneficial traits, many are neutral or nearly neutral, and some result in deleterious phenotypes. While it is commonly believed that DNA mutations affect evolutionary phenotypic trajectories over millions of years, scientific advances have shown that this...
Published: 2/13/2025   |   Inventor(s): Stephan Baehr, Jean-Francoi Gout, Michael Lynch
Keywords(s):  
Category(s): Applied Technologies, Computing & Information Technology, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Genomic Assays/Reagents/Tools, Life Science (All LS Techs)
Liquid Mutation Accumulation Experiment
Mutation accumulation (MA) experiments are widely used in evolutionary biology for studying the effects, rates and properties of new spontaneous mutations. Despite this, they are laborious to execute, typically taking months to years to a acquire sufficient mutations to measure mutation rates and spectra. Further, typical tools such as agar plates and...
Published: 2/13/2025   |   Inventor(s): Stephan Baehr, Wei-Chin Ho, Michael Lynch
Keywords(s):  
Category(s): Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Genomic Assays/Reagents/Tools, Life Science (All LS Techs)
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