Search Results - genomic+assays%2freagents%2ftools

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RNA Sensor Platform for Targeting Cancer Fusion Genes and Transcripts
Many cancers have recurrent chromosomal translocations leading to the fusion of two genes. Often, said cancers are aggressive, have a poor prognosis with metastasis or recurrence, and do not have effective and targeted treatment. The challenge of many fusion-positive cancers is the lack of established targets downstream of the gene fusion despite years...
Published: 10/8/2024   |   Inventor(s): Albert Cheng, Ching Lau, Nathaniel Jilette, Jacqueline Jufen Zhu
Keywords(s):  
Category(s): Cancer, Cancer Therapeutics, Chemical/Biological Sensors, Genomic Assays/Reagents/Tools, Life Science (All LS Techs)
DNA Sequencing by Molecular Recognition and Nanoscale Manipulation of Single Molecules
The US Government's pursuit of the "Thousand Dollar Genome" and the "X Prize" goal of even lower cost DNA sequencing are striking examples of the importance being assigned to advances in methods for the DNA sequencing of the human genome. The first technology that finally allows for truly routine genome sequencing will open a new...
Published: 10/17/2024   |   Inventor(s): Stuart Lindsay, Jin He, Peiming Zhang, Kevin Reinhart
Keywords(s):  
Category(s): Life Science (All LS Techs), Bioanalytical Assays, Chemistries & Devices, Genomic Assays/Reagents/Tools
DNA Sequencing and Mutation Rate Estimation
DNA mutations are the basis of all heritable biological variation. Some variation gives rise to beneficial traits, many are neutral or nearly neutral, and some result in deleterious phenotypes. While it is commonly believed that DNA mutations affect evolutionary phenotypic trajectories over millions of years, scientific advances have shown that this...
Published: 5/7/2024   |   Inventor(s): Stephan Baehr, Jean-Francoi Gout, Michael Lynch
Keywords(s):  
Category(s): Applied Technologies, Computing & Information Technology, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Genomic Assays/Reagents/Tools, Life Science (All LS Techs)
Liquid Mutation Accumulation Experiment
Mutation accumulation (MA) experiments are widely used in evolutionary biology for studying the effects, rates and properties of new spontaneous mutations. Despite this, they are laborious to execute, typically taking months to years to a acquire sufficient mutations to measure mutation rates and spectra. Further, typical tools such as agar plates and...
Published: 6/4/2024   |   Inventor(s): Stephan Baehr, Wei-Chin Ho, Michael Lynch
Keywords(s):  
Category(s): Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Genomic Assays/Reagents/Tools, Life Science (All LS Techs)
DNA Methylation Barriers
In normal differentiated cells, most of the genome is densely methylated, except CpG islands near promoters of actively transcribed genes. Maintaining this boundary between unmethylated promoter-associated and adjacent methylated regions is crucial as loss of segregation can lead to disease. Unfortunately, it is not clear where these boundaries are,...
Published: 6/5/2024   |   Inventor(s): Li Liu, Jingmin Shu
Keywords(s):  
Category(s): Applied Technologies, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Diagnostic Assays/Devices
Multiplexed HLA mRNA Preparation for Downstream Sequencing
Human Leukocyte Antigens (HLA) are protein complexes residing on cell surfaces responsible for regulating immune responses. HLA haplotype sequencing is integral to the development of personalized therapies and diagnostics. It is also paramount to the understanding of T cell mediated immunity. There are over six classical major HLA loci with over 32,000...
Published: 2/9/2024   |   Inventor(s): Oliver Kask, Mark Knappenberger, Karen Anderson
Keywords(s):  
Category(s): Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Life Science (All LS Techs), Genomic Assays/Reagents/Tools
Pathogen Molecular Detection Platform
Accurate detection and diagnosis of infectious diseases is paramount to appropriate treatment and better outcomes. Despite tremendous efforts to advance new diagnostic techniques, there are still critical gaps in the healthcare system in quickly diagnosing and responding to infectious diseases. Current diagnostic technologies identify pathogens by detecting...
Published: 1/31/2024   |   Inventor(s): Alexander Green, Keith Pardee, Margot Karlikow, Kaiyue Wu, Masoud Norouzi
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Medical Diagnostics/Sensors, Proteomic Assays/Reagents/Tools, COVID-19, Coronavirus, SARS-CoV-2
Pathogen Molecular Detection Platform
Accurate detection and diagnosis of infectious diseases is paramount to appropriate treatment and better outcomes. Despite tremendous efforts to advance new diagnostic techniques, there are still critical gaps in the healthcare system in quickly diagnosing and responding to infectious diseases. Current diagnostic technologies identify pathogens by detecting...
Published: 10/17/2023   |   Inventor(s): Alexander Green, Duo Ma
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Bioanalytical Assays, Chemistries & Devices, Chemical/Biological Sensors, Diagnostic Assays/Devices, Applied Technologies, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools, Medical Diagnostics/Sensors
Increasing the Antigenic Insertion Sites on the Recombinant Immune Complex Platform
Recombinant protein subunit vaccines offer an improved safety profile compared to live attenuated or inactivated vaccines, making them a promising vaccine strategy. These vaccines can further enhance immunogenicity through fusion with IgG-based protein scaffolds, such as immune complex (RIC) platforms. RIC consists of an antibody and antigen complex...
Published: 9/18/2023   |   Inventor(s): Hugh Mason, Mary Pardhe, Andrew Diamos
Keywords(s):  
Category(s): Vectors/Constructs/Plasmids, Vaccines/Antimicrobials, Non-Cancer Therapeutics, Life Science (All LS Techs), Genomic Assays/Reagents/Tools, Protein/Pharma Production in Plants
High-Throughput Direct-Measurement of Telomere Length
Telomeres are linear chromosome end-capping repetitive DNA sequences. They serve to protect the ends of chromosomes from undesirable fusion events, thus integrity and length are crucial for stability. Natural attrition as well as mutations can affect telomere integrity and length resulting in chromosome instability, senescence, cell death and human...
Published: 8/14/2023   |   Inventor(s): Julian Chen, Yang Li, Dhenugen Logeswaran
Keywords(s):  
Category(s): Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Medical Diagnostics/Sensors
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