Search Results - suzanne+emerson

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Enhanced S10-3 Cell Line for Advanced Hepatitis E Virus Research and Therapeutic Development
The Huh-7 cell line underwent a detailed sub-cloning process to enhance its effectiveness for Hepatitis E Virus (HEV) infection studies. This involved diluting and culturing cells in 96-well plates until confluent monolayers formed, followed by selection and expansion of the most suitable cells. The sub-clone S10-3, derived from this process, was identified...
Published: 12/10/2024   |   Inventor(s): Suzanne Emerson, Hanh Nguyen, Udana Torian
Keywords(s):  
Category(s): Application > Research Materials, ResearchProducts, ResearchProducts > Human Cell Lines, TherapeuticArea > Infectious Disease
Hepatitis C Virus Cell Culture System
Hepatitis C virus (HCV) infection causes chronic liver disease and is a major global health problem with an estimated 170 million people affected worldwide and 3-4 million new cases every year. Therapeutic advances will be greatly aided by the ability of researchers to successfully replicate and characterize the virus in vitro. The study of HCV replication...
Published: 10/28/2024   |   Inventor(s): Rodney Russell, Robert Purcell, Suzanne Emerson
Keywords(s): Cells, CULTURE, DDXXXX, DXXXXX, Hepatitis A, HEPATITIS C, Hepatitis D, Hepatitis E, Hepatocellular carcinoma, adult, HEPATOMA, Huh-7, Huh-7.5, Subclone
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Research Materials
Monoclonal Antibodies Against Orthopoxviruses
Concerns that variola (smallpox) virus might be used as a biological weapon have led to the recommendation of widespread vaccination with vaccinia virus. While vaccination is generally safe and effective for prevention of smallpox, it is well documented that various adverse reactions in individuals have been caused by vaccination with existing licensed...
Published: 10/28/2024   |   Inventor(s): Bernard Moss, Suzanne Emerson, Robert Purcell, Patricia Earl, Zhaochun Chen
Keywords(s): Against, antibodies, DAXXXX, DB4BXX, DB4XXX, DBXXXX, DC5BXX, DC5XXX, DCXXXX, DDXXXX, DXXXXX, monoclonal, ORTHOPOXVIRUSES
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease
Monoclonal Antibodies that Neutralize B. anthracis Protective Antigen (PA), Lethal Factor (LF) and Edema Factor (EF)
Anthrax, whether resulting from natural or bioterrorist-associated exposure, is a constant threat to human health. The lethality of anthrax is primarily the result of the effects of anthrax toxin, which has 3 components: a receptor-binding protein known as "protective antigen" (PA) and 2 catalytic proteins known as "lethal factor" (LF) and "edema factor"...
Published: 10/28/2024   |   Inventor(s): Stephen Leppla, Suzanne Emerson, Robert Purcell, Mahtab Moayeri, Zhaochun Chen
Keywords(s): Anthrax, antibodies, ANTIBODY, ANTIGEN, Chimpaneze, DA3XXX, DAXXXX, DB3XXX, DBXXXX, DC4XXX, DCXXXX, DDXXXX, DXXXXX, Edema, FACTORS, Lethal, monoclonal, Neutralize, Neutralizes, PA, Protective, That, toxin, UAXXXX
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Vaccines, TherapeuticArea > Rare / Neglected Diseases, Application > Therapeutics, TherapeuticArea > Infectious Disease
Swine Hepatitis E Virus Available For Use in Diagnosis, Prevention and Treatment of Hepatitis E
Hepatitis E virus (HEV) is the cause of Hepatitis E, a liver disease that occurs primarily in developing countries due to fecal contaminated drinking water. Outbreaks of HEV infection have caused epidemics in Africa, Central and Southeast Asia and Mexico and cases of the disease have also been reported sporadically in more developed countries. Hepatitis...
Published: 10/28/2024   |   Inventor(s): Suzanne Emerson, Robert Purcell, Xiang-jin Meng
Keywords(s): DC5BXX, DC5XXX, DCXXXX, Duke DNA Project, DXXXXX, e, Hepatitis, Hepatitis A, Hepatitis D, Hepatitis E, HEV, PCT/US98/14665, Swine, THEREOF, UAXXXX, USES, virus
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Rare / Neglected Diseases, TherapeuticArea > Infectious Disease, Application > Vaccines
Neutralizing Monoclonal Antibodies to Botulinum Neurotoxin Type A
Two chimpanzee mAbs specifically reacted with light chain of the botulinum neurotoxin A and neutralize the toxin in the mouse model. They can be used for emergency prophylaxis and treatment of either naturally acquired or terrorist associated botulism. Since the sequence of chimpanzee immune globulin is virtually identical to that of humans, the MAbs...
Published: 10/28/2024   |   Inventor(s): Robert Purcell, Suzanne Emerson, Zhaochun Chen
Keywords(s): Botulinum, DB3XXX, DBXXXX, DXXXXX, Hybridoma, Listed LPM Chang as of 4/15/2015, mabs, Neurotoxin, Neutralizing, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RM, UA1XXX, VJXXXX, WAXXXX, WIXXXX, XAXXXX
Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Rare / Neglected Diseases, Application > Diagnostics, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Immunology, TherapeuticArea > Infectious Disease, ResearchProducts > Antibodies
Monoclonal Antibodies That Bind or Neutralize Hepatitis B Virus
Hepatitis B virus (HBV) chronically infects over 300 million people worldwide. Many of them will die of chronic hepatitis or hepatocellular carcinoma. The present technology relates to the isolation and characterization of a novel neutralizing chimpanzee monoclonal antibody to HBV. The antibody was identified through a combinatorial antibody library...
Published: 10/28/2024   |   Inventor(s): Robert Purcell, Suzanne Emerson
Keywords(s): ANTIBODY, B, Chimpanzee, DB4BXX, DB4XXX, DBXXXX, DDXXXX, DXXXXX, Hepatitis, Hepatitis A, Hepatitis D, Hepatitis E, monoclonal, Neutralizes, That, virus
Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Infectious Disease, Application > Therapeutics
Four Chimpanzee Monoclonal Antibodies that Neutralize Hepatitis A Virus
This invention claims antibodies and/or fragments thereof specific for hepatitis A virus (HAV) and the use of the antibodies in the diagnosis, prevention, and treatment of hepatitis A. Hepatitis A is the most common type of hepatitis reported in the United States, which reports an estimated 134,000 cases annually, and infects at least 1.4 million people...
Published: 10/28/2024   |   Inventor(s): Darren Schofield, Suzanne Emerson, Robert Purcell
Keywords(s): DB4BXX, DBXXXX, DCXXXX, DXXXXX, Hepatitis A, Hepatitis D, Hepatitis E
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics, Application > Vaccines
Major Neutralization Site of Hepatitis E Virus and Use of this Neutralization Site in Methods of Vaccination
Hepatitis E is endemic in many countries throughout the developing world, in particular on the continents of Africa and Asia. The disease generally affects young adults and has a very high mortality rate, up to 20%, in pregnant women. This invention relates to the identification of a neutralization site of hepatitis E virus (HEV) and neutralizing...
Published: 10/28/2024   |   Inventor(s): Suzanne Emerson, Robert Purcell
Keywords(s): DC5BXX, DCXXXX, DXXXXX, Hepatitis A, Hepatitis D, Hepatitis E
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Vaccines
Recombinant Proteins of the Swine Hepatitis E Virus and Their Uses as a Vaccine and Diagnostic Reagents for Medical and Veterinary Applications
This invention is based on the discovery of the swine hepatitis E virus (swine HEV), the first animal strain of HEV identified and characterized, and its ability to infect across species. The inventors have found that the swine HEV is widespread in the general pig population in the United States and other countries and that swine HEV can infect non-human...
Published: 10/28/2024   |   Inventor(s): Xiang-jin Meng, Robert Purcell, Suzanne Emerson
Keywords(s): DA4BXX, DAXXXX, DC5BXX, DCXXXX, DXXXXX, Hepatitis A, Hepatitis D, Hepatitis E
Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Vaccines, TherapeuticArea > Infectious Disease
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