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Cyanobacterial Hosts and Methods for Producing Structurally Diverse Chemicals
Engineered Cyanobacterial System for the Production of Natural Products Such as ShinorineThis genetically modified cyanobacterial host system uses Synechocystis as the host bacteria to produce structurally diverse natural products. Cyanobacterial natural products and their analogs are useful chemicals in health, agriculture and other industries. While...
Published: 1/6/2025
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Inventor(s):
Guang Yang
,
Yousong Ding
Keywords(s):
Chemical
,
cyanobacterial
,
host development
,
precursor
,
Production
,
secondary metabolites
Category(s):
Technology Classifications > Others > Others
An Iterative Approach to Polish the Nanopore Sequencing Basecalling for Therapeutic RNA Quality Control
This invention is for the improvement of nanopore sequencing base calling accuracy via an iterative approach involving the use of existing machine learning algorithms and alignment with ground-truth references. This new method allows base calling accuracy to improve as the technology is trained, which in turn creates countless opportunities for sequencing...
Published: 12/11/2024
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Inventor(s):
Hongxu Ding
Keywords(s):
Category(s):
Technology Classifications > Life Sciences > Vaccines
,
Technology Classifications > Life Sciences > RNAi/siRNA
,
Technology Classifications > Research Tools > Simulators and Modeling Tools
,
Technology Classifications > Software & Information Technology > Health IT
Targeting mTOR-Related Autophagy Dysfunction to Treat Age-Related Hearing Loss with Rapamycin and Its Derivatives
Advantages: Novel Application of FDA approved drugs, rapamycin and its derivatives, for treating age-related hearing loss (ARHL). Targeting mTOR alleviates oxidative stress and inflammation in the cochlea, enhancing cellular health and resilience to age-related damage. Potential to Reverse or Delay Age-related hearing loss (ARHL) in patients. Summary: Age-related...
Published: 11/5/2024
|
Inventor(s):
Robert Frisina
,
Xiaohua Zhu
,
Bo Ding
,
Xiaoxia Zhu
Keywords(s):
Pharmaceuticals
,
Therapeutics
Category(s):
Technology Classifications > Medical > Therapeutics
,
Technology Classifications > Medical > Pharmaceuticals
,
Technology Classifications > Medical > Biotechnology
,
Technology Classifications > Medical > Biomedical Engineering
,
Technology Classifications > Medical > Medical Devices
Iridium-based Integrated Electrode for Solid Polymer Electrolyte Electrolyzer Cell System
Proton Exchange Membrane Electrolyzer Technologies From the EESC Lab Hydrogen power is one of several forms of energy expected to play a major role in a sufficiently advanced de-carbonized energy system, with electrolysis being a promising route for the green production of hydrogen from renewable energy sources. Among various other electrolyzer technologies,...
Published: 6/7/2024
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Inventor(s):
Feng Yuan Zhang
,
Lei Ding
,
Kui Li
,
Weitian Wang
Keywords(s):
Category(s):
Chemistry & Materials
mAbs Inhibit Human RAGE by Blocking Its Binding to Heparan Sulfate
Monoclonal antibodies that block heparan sulfate binding to human RAGE, preventing its activation in disease states to serve as a therapeutic treatment. Background: Receptor for Advanced Glycation End products (RAGE), a widely expressed inflammatory receptor for disease states such as atherosclerosis, cancer, Alzheimer disease, drug-induced liver...
Published: 7/9/2024
|
Inventor(s):
Ding Xu
,
Chih Yean Ong
,
Miaomiao Li
Keywords(s):
Featured
,
Technologies
Category(s):
Campus > University at Buffalo
,
Technology Classifications > Antibodies
,
Technology Classifications > Therapeutics and Vaccines
Human Serum Albumin-Transgenic Mouse
A novel human albumin transgenic mouse model was developed which can be used to establish human protein biomarkers of exposure to hazardous xenobiotics for human risk assessment via animal studies. This can provide a unique in vivo tool for the assessment of risks of toxicity associated with human exposure to environmentally hazardous chemicals and...
Published: 1/10/2024
|
Inventor(s):
Xinxin Ding
Keywords(s):
Category(s):
Technology Classifications > Research Tools > Animal Models
,
Technology Classifications > Life Sciences
Molecular Imaging of the Cochlea
Advantages: Microenvironment Sensitivity: Unveils subtle structural changes within the cochlear microenvironment, enhancing auditory health understanding. Treatment Response Tracking: Precisely quantifies potassium concentration changes, enabling accurate monitoring of treatment responses and disease progression. Non-Invasive Approach: Offers...
Published: 9/11/2024
|
Inventor(s):
Parveen Bazard
,
Mikalai Budzevich
,
Xiaoxia Zhu
,
Bo Ding
,
Robert Frisina
Keywords(s):
Diagnostics
,
Medical Imaging
Category(s):
Technology Classifications > Medical > Medical Imaging
,
Technology Classifications > Medical > Medical Diagnostics
Systems and Algorithms for Few-Shot Node Classification on Graphs
Node classification in real-world attributed networks is a central analytical task that is a growing research area. In real-world networks, a large portion of node classes only contain limited labeled instances. Many prevailing graph machine learning methods typically rely upon the availability of sufficient labeled data. However, the long-tail...
Published: 10/16/2023
|
Inventor(s):
Kaize Ding
,
Jianling Wang
,
Huan Liu
Keywords(s):
Algorithm Development
,
Data Mining
,
Machine Learning
,
Neural Computing
,
PS-Computing and Information Technology
,
Social Media
Category(s):
Physical Science
,
Computing & Information Technology
Hormone Treatment for Age-Related Hearing Loss-Presbycusis
Competitive Advantages Utilizes natural and FDA-approved compounds Suitable for systemic applications Minimal side effects Summary Our researchers have developed a novel drug combination of FDA-approved compounds that achieve significant therapeutic effects in the treatment of ARHL. These compounds include aldosterone, ammonium chloride,...
Published: 8/20/2024
|
Inventor(s):
Bo Ding
,
Joseph Walton
,
Xiaoxia Zhu
,
Robert Frisina
Keywords(s):
Category(s):
Technology Classifications > Medical > Pharmaceuticals
Fast Volumetric Imaging of Fluorescent Tissue Structures and Activities
Researchers at the University of Arizona have developed a novel microscope imaging technique that generates high-resolution large-volume 3D images of tissue at subcellular resolution, and captures transient activities within the volume at 100 volume frames per second (vps). The invention breaks away from the traditional plane-scanning approach and implements...
Published: 2/28/2024
|
Inventor(s):
Leilei Peng
,
Jun Ding
,
Dongli XU
Keywords(s):
Category(s):
Technology Classifications > Imaging & Optics
,
Technology Classifications > Imaging & Optics > Medical Imaging
,
Technology Classifications > Imaging & Optics > Microscopy, Spectroscopy, Polarimetry
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