Search Results - dennis+kyle

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Leishmania Inhibitors Derived from Deep-Sea Coral

Competitive Advantages Specific inhibition of Leishmania donovani parasites A natural drug candidate Does not produce toxic side effects Summary Our researchers have identified a novel metabolite derived from an Antarctic marine coral that shows promise as a new treatment option for leishmaniasis infections. Antactic marine invertebrates are...

Published: 11/7/2024 | Inventor(s): Bill Baker, Nerida Wilson, Dennis Kyle, Anne-Claire Limon

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Category(s): Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical

Quinolone-Based Compounds, Formulations, and Uses Thereof

Competitive Advantages High aqueous solubility Targets multiple stages of malaria Effective against multidrug resistant malaria strains Prevents malaria infections and treats current infections Summary USF researchers have developed quinolone-based compounds and methods of treatment that can be used to prevent and treat malaria....

Published: 8/25/2023 | Inventor(s): Alexis LaCrue, Dennis Kyle, Jordany Maignan, Roman Manetsch

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Category(s): Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical

Anti-infective Agents with Novel Chemical Scaffolds

Competitive Advantages Potentially more effective than current treatments Less toxic than current treatments Treats a variety of bacterial pathogens Compound can be administered in a variety of delivery methods Summary Heat Shock Protein 90 (Hsp90) is known to be a highly conserved protein amongst these bacterial pathogens and...

Published: 8/26/2023 | Inventor(s): Ankush Kanwar, Benjamin Eduful, Brian Vesely, Dennis Kyle, Linda Barbeto, James Leahy

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Category(s): Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical

Treatment for the Neglected Tropical Disease Leishmaniasis

Competitive Advantages Potent activity against Leishmaniasis parasite Low toxicity to healthy cells Parasite shows no resistance Summary The marine sponge, Dendrilla membranosa, produces a series of compounds with varying degrees of biological activity against the parasite Leishmania donovani. USF researchers have developed novel...

Published: 11/7/2024 | Inventor(s): Brian Vesely, Christopher Witowski, Dennis Kyle, John Maschek, Bill Baker

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Category(s): Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical

4(1H)-Quinolones Having Antimalarial Activity with Reduced Chemical Resistance

Competitive Advantages Potent anti-malarial activity Improved chemical resistance against multi-drug resistant (MDR) parasites Acts on both MDR parasites and drug susceptible anti-malarial strains equally well Summary This invention promises a great approach to treat those affected with malaria. The compound possesses a potent EC50...

Published: 8/27/2023 | Inventor(s): Alexis LaCrue, Dennis Kyle, Fabian Saenz, Jordany Maignan, Niranjan Namelikonda, Richard Cross, Tina Mutka, Roman Manetsch

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Category(s): Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical

Compounds Having Anti-Parasitic or Anti-Infective Activity

Competitive Advantages Effective on liver and blood stages of malaria Effective against drug-resistant strains of Plasmodium parasites Summary Chloroquine replacement drugs are urgently needed to treat and prevent malaria. The endoperoxides, like artemisinin are being used in other parts of the world for malaria therapy. However, the...

Published: 8/27/2023 | Inventor(s): Aaron Nilsen, David Hinrichs, Dennis Kyle, Jane Kelly, Jeremy Burrows, Martin Smilkstein, Michael Riscoe, Richard Cross, Rolf Winter, Roman Manetsch

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Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Pharmaceuticals