Search Results - replacement

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Modulating Autophagy as a Treatment for Lysosomal Storage Diseases
Researchers at NIAMS have developed a technology for treatment of lysosomal storage diseases by inhibition of autophagy. Pompe disease is an example of a genetic lysosomal storage disease caused by a reduction or absence of acid alpha-glucosidase (GAA). Patients with Pompe disease have a lysosomal buildup of glycogen in cardiac and skeletal muscle...
Published: 8/14/2024   |   Inventor(s): Cynthia Schreiner, Paul (Estate of) Plotz, Shoichi Takikita, Tao Xie, Rebecca Baum, Nina Raben
Keywords(s): Acid, A-glucosidase, Autophagy, B, Clearance, Complete, DEFICIENCY, Disabling, Disease, Enzyme, ERT, GB1XXX, GBXXXX, Genetic, GLYCOGEN, GXXXXX, IBXXXX, Inactivation, IXXXXX, Lysosomal, Model, Mouse, MUSCLE, Near, Patent Category - Biotechnology, Permits, Pompe, REPLACEMENT, SKELETAL, Storage, STORED, THERAPY, UA1XXX
Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Rare / Neglected Diseases, Application > Diagnostics, Application > Research Materials
A non-electronic reference implant for detection of implant loosening after joint replacement surgery
Joint replacement is an effective surgical intervention for some joint diseases. Implant loosening is a disabling condition that can affect patients after joint replacement surgery. Unfortunately, subtle progression of tissue deterioration around the implant remains a major challenge, because signs and symptoms may not be clinically apparent until...
Published: 3/5/2024   |   Inventor(s): Hanna Dietrich, Joseph DiFranceisco, Miguel Isaga, Luke Austin, Erik Brewer, Hamid Seyyedhosseinzadeh, Mary Staehle, Ann DiGuglielmo
Keywords(s): Arthroplasty, Implant, Joint, Radiography, Replacement , Surgery
Category(s): Human Health Care > Medical Devices, Human Health Care > Biomarkers, Diagnosis and Detection