Search Results - amit+tiwari

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Antiproliferative necroptosis inducers or autophagy inhibitors or a combination thereof
​​​​​​Background Breast cancer is the leading cause of cancer-related deaths in women worldwide, and triple negative breast cancer (TNBC) accounts for approximately 15-20% of these cancers. TNBC tumors do not express three key therapeutically relevant cell-surface receptors: estrogen receptor (ER), progesterone receptor (PR), and overexpression of...
Published: 6/18/2024   |   Inventor(s): Amit Tiwari, Chandrabose Karthikeyan, Angelique Nyinawabera
Keywords(s):  
Category(s): Oncology
Cancer Therapy via Simultaneous Non-apoptotic Cell Death Mechanisms
Project ID: D2018-15 Background Most of current cancer therapy employs drugs that act through apoptotic signaling pathways. However, cancer cells often acquire mutations that can diminish apoptosis and lead to chemo-resistance when coupled with increased capacity for drug efflux and DNA repair. This results in chemotherapeutic failure especially...
Published: 6/18/2024   |   Inventor(s): Amit Tiwari, Chandrabose Karthikeyan, Haneen Amawi, Paul Erhardt, Piyush Trivedi
Keywords(s): Autophagy, Cancer, Drug-resistance, Methuosis, Non-apoptotic cell death
Category(s): Oncology
Targeting LASP1, eIF4A1, eIF4B, and CXC4 with Modulators for treating cancer
Project ID: D2019-32 Background: Breast cancer (BC) is a heterogeneous disease and is the second leading cause of death in women among the cancer mortalities. With the new estimates in 2019, 3 out of 10 women will develop BC in her lifetime and 1 in 7 will succumb to BC. Mortality in BC patients is mainly due to metastasis to the lungs, bone, and brain....
Published: 5/9/2024   |   Inventor(s): Dayanidhi Raman, Cory Howard, John Nemunaitis, F. Charles Brunicardi, Shi-He Liu, Amit Tiwari
Keywords(s): Cancer, CXCL12, CXCL8, CXCLB, CXCR4, eIF4A, LASP1, mTNBC, NACT, pCR, TNBC, Triple negative breast cancer
Category(s): Oncology