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Search Results - yuan-i+chen
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Novel Small Molecule Inhibitors Targeting Clostridioides Difficile Sporulation
Advantages: The development of DBO compounds represents a novel therapeutic approach to tackling CDI. By inhibiting C. difficile sporulation, DBO compounds address a major cause of CDI recurrence, reducing the likelihood of patients experiencing repeated infections. DBO compounds improve the effectiveness of existing antibiotics used to treat...
Published: 10/2/2023
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Inventor(s):
Yu Chen
,
Michael Sacco
,
James Leahy
,
Elena Bray
,
Xingmin Sun
,
Xiujun Zhang
Keywords(s):
Drug Discovery
,
Infectious Diseases Treatment
Category(s):
Technology Classifications > Medical > Therapeutics
,
Technology Classifications > Medical > Pharmaceuticals
,
Technology Classifications > Medical > Medical Diagnostics
,
Technology Classifications > Medical > Infectious Diseases
,
Technology Classifications > Medical > Biotechnology
Low-cost fluorescent reporters for nuclease activity detection
Problem DNA cleavage or nuclease activity detection is important in many forms of nucleic acid amplification tests. The current detection technologies rely on the use of fluorescence resonance energy transfer (FRET) reporters that light up upon digestion, such as the Taqman® probe and the DNaseAlert®. Although these FRET reporters well serve...
Published: 6/6/2024
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Inventor(s):
Hsin-Chih (Tim) Yeh
,
Soonwoo Hong
,
Yuan-I Chen
,
Yu-An Kuo
,
Trung Nguyen
,
Hsin-Chin Li
Keywords(s):
Category(s):
Life sciences > Research tools > Tool/assay/screening platform
,
Life sciences > Agriculture > Animal/veterinary
Deep learning for rapid and robust fluorescence lifetime imaging
Deep-learning approach has the potential to unlock fluorescent lifetime imaging for clinical applications. Fluorescence lifetime imaging microscopy (FLIM) is a widely used tool for biomedical imaging that offers many unique advantages over typical intensity-based fluorescence microscopy. FLIM is advancing fundamental biological research by enabling...
Published: 11/1/2023
|
Inventor(s):
Hsin-Chih (Tim) Yeh
,
Yuan-I Chen
,
Yin-Jui Chang
,
Shih-Chu Liao
,
Trung Nguyen
,
Soonwoo Hong
,
Yu-An Kuo
,
Hsin-Chin Li
Keywords(s):
Artificial intelligence (AI)
,
Cancer
,
Diagnostics
,
Imaging
,
Machine learning
,
Medical imaging
,
Microscopy
Category(s):
Life sciences > Imaging > Microscopy
,
Life sciences > Imaging
Novel Multi-Omics Aging Clock
A multi-omics clock analyzes multiple layers of omics data with machine learning to predict remaining lifespan of mammals, particularly for animal model studies. Large omics data sets may be used from combinations of genomics, proteomics, lipids, etc. available from blood or other simple sample collection. This tool can robustly capture changes...
Published: 3/12/2024
|
Inventor(s):
George Sutphin
,
Samuel Freitas
,
Megha Padi
,
Chen Chen
Keywords(s):
Category(s):
Technology Classifications > Life Sciences > Biomarkers
,
Technology Classifications > Research Tools > Animal Models
,
Technology Classifications > Research Tools > Screening assays
,
Technology Classifications > Research Tools > Simulators and Modeling Tools
Autonomous Drone for railroad track inspection
Reference #: 01564 The University of South Carolina is offering licensing opportunities for Autonomous Drone for railroad track inspection Background: The current practices suffer from three main drawbacks: 1) Human pilot cost is significant. The schedule of the drone-based track inspection is contingent on the pilot’s availability rather than...
Published: 3/15/2023
|
Inventor(s):
Yu Qian
,
Yi Wang
,
Chen Chen
Keywords(s):
autonomous drone
,
flight control
,
image processing
,
railroad track inspection
,
self-navigation
Category(s):
Engineering and Physical Sciences
Tetrazole & Coumarin Phosphonate Based Broad-Spectrum Beta-Lactamase Inhibitors
Competitive Advantages Combats bacterial antibiotic resistance to β-Lactamase Effectively inhibits against the different classes of β-Lactamase Enhances effectiveness of current β-lactam antibiotics treatments Summary Our inventors have discovered tetrazole and coumarin phosphonate based compounds can actively inhibit...
Published: 6/27/2024
|
Inventor(s):
Yu Chen
,
Orville Pemberton
,
Adam Renslo
,
Priyadarshini Jaishankar
Keywords(s):
Infectious Diseases Treatment
,
Pharmaceuticals
Category(s):
Technology Classifications > Medical > Pharmaceuticals
,
Technology Classifications > Medical
Beta-Lactamase Inhibitor Compositions, Methods of Use, and Methods of Treatment
Competitive Advantages Can restore the efficacy of beta-lactam antibiotics Overcomes antibiotic resistance May help to develop new antibiotic treatment regimens Treats multi-drug resistant organisms Summary Our researchers have developed compositions comprised of a beta-lactamase inhibitor and methods of use to treat various infections and...
Published: 6/27/2024
|
Inventor(s):
Adam Renslo
,
Derek Nichols
,
Priyadarshini Jaishankar
,
Yu Chen
,
Erica Lauterwasser
Keywords(s):
Infectious Diseases Treatment
,
Pharmaceuticals
Category(s):
Technology Classifications > Medical > Infectious Diseases
,
Technology Classifications > Medical > Pharmaceuticals
,
Technology Classifications > Medical
2015-671 Underground Shafts for Hydrogen Storage
SummaryResearchers at UCLA have developed an underground drilled shaft concept for storage of hydrogen or other gases.BackgroundOne challenge in creating a hydrogen economy is developing hydrogen gas storage solutions. Increased interest has helped the global hydrogen storage market grow to $2.6 billion in 2016, and it is expected to reach over $5...
Published: 7/19/2023
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Inventor(s):
Adrienne Lavine
,
Hossein Kavehpour
,
Dante Simonetti
,
Richard Wirz
,
Chen Chen
,
Gabriela Bran
,
Gopinath Warrier
,
Hamarz Aryafar
,
Jonathon Kennedy
,
Joshua Jordan
,
Keith Lovegrove
Keywords(s):
Energy & Water
Category(s):
Energy & Environment > Energy Generation > Solar
,
Energy & Environment > Energy Storage
A System For Visual Presentation Of Concepts From Ontology And Text Documents
PAGE TITLEOverviewPAGE SUMMARYA system lets a user click on a location of a brain model to explore neuroscience ontology terms related to the location. The user can further explore the related terms and related documents through a visualization interface and learn new concept or document relationships derived from the ontology and annotated document...
Published: 7/24/2024
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Inventor(s):
Yuan An
,
Xia Lin
,
Mi Zhang
,
Yue Shang
Keywords(s):
Category(s):
Computing, Software, Analytics & Information Technology
,
Computing, Software, Analytics & Information Technology > Computing: Algorithms
,
Computing, Software, Analytics & Information Technology > Computing: Contextual Analytics
,
Computing, Software, Analytics & Information Technology > Computing: Data Mining
,
Computing, Software, Analytics & Information Technology > Computing: Databases
Chance-Constrained Optimization for Treatment of Prostate and Other Cancers in Intensity-Modulated Proton Therapy
The quality of IMPT treatment plans may be drastically diminished by uncertainties such as proton range and patient setup errors. If these uncertainties are not figured into treatment planning, the dose distribution that the patient receives may not be the same as the planned dose distribution. New treatment plans, which include optimized software/programming,...
Published: 4/19/2023
|
Inventor(s):
Jianming Liang
,
Yu An
,
Wei Liu
Keywords(s):
Category(s):
Computing & Information Technology
,
Life Science (All LS Techs)
,
Medical Imaging
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