Search Results - yuan-i+chen

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Enhanced fluorescence via DNA aptamer optimization

This invention improves the fluorescence of DNA-based aptamers by substituting the original fluorophore with TO1-biotin and identifying a critical mutation that further enhances fluorescence. Background Fluorogenic DNA aptamers (FAPs) are a crucial tool in molecular biology, particularly for applications like live-cell imaging and highly specific...

Published: 12/6/2024 | Inventor(s): Hsin-Chih (Tim) Yeh, Yuan-I Chen, Yu-An Kuo, Yujie He, Trung Nguyen, Soonwoo Hong, Anh-Thu Nguyen, Sohyun Kim, Saeed Seifi

Keywords(s):

Category(s): Life sciences > Research tools > Tool/assay/screening platform

Fluorescence lifetime imaging for retinal function assessment

This invention uses a laser-based imaging system to study the eye’s retina. By measuring light responses, it provides insights into retinal health and potential diseases like age-related macular degeneration. Background Two-photon excited fluorescence (TPEF) is a powerful technique used to study the eye. TPEF allows researchers to excite intrinsic...

Published: 10/24/2024 | Inventor(s): Hsin-Chih (Tim) Yeh, Trung Nguyen, Yuan-I Chen, H. Grady Rylander, Yu-An Kuo, Soonwoo Hong, Anh-Thu Nguyen, Yujie He

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Category(s): Life sciences > Imaging, Life sciences > Imaging > Microscopy

Novel Small Molecule Inhibitors Targeting Clostridioides Difficile Sporulation

Advantages: The development of DBO compounds represents a novel therapeutic approach to tackling CDI. By inhibiting C. difficile sporulation, DBO compounds address a major cause of CDI recurrence, reducing the likelihood of patients experiencing repeated infections. DBO compounds improve the effectiveness of existing antibiotics used to treat...

Published: 10/2/2023 | Inventor(s): Yu Chen, Michael Sacco, James Leahy, Elena Bray, Xingmin Sun, Xiujun Zhang

Keywords(s): Drug Discovery, Infectious Diseases Treatment

Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Biotechnology

Low-cost fluorescent reporters for nuclease activity detection

Problem DNA cleavage or nuclease activity detection is important in many forms of nucleic acid amplification tests. The current detection technologies rely on the use of fluorescence resonance energy transfer (FRET) reporters that light up upon digestion, such as the Taqman® probe and the DNaseAlert®. Although these FRET reporters well serve...

Published: 6/6/2024 | Inventor(s): Hsin-Chih (Tim) Yeh, Soonwoo Hong, Yuan-I Chen, Yu-An Kuo, Trung Nguyen, Hsin-Chin Li

Keywords(s):

Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Agriculture > Animal/veterinary

Deep learning for rapid and robust fluorescence lifetime imaging

Deep-learning approach has the potential to unlock fluorescent lifetime imaging for clinical applications. Fluorescence lifetime imaging microscopy (FLIM) is a widely used tool for biomedical imaging that offers many unique advantages over typical intensity-based fluorescence microscopy. FLIM is advancing fundamental biological research by enabling...

Published: 11/1/2023 | Inventor(s): Hsin-Chih (Tim) Yeh, Yuan-I Chen, Yin-Jui Chang, Shih-Chu Liao, Trung Nguyen, Soonwoo Hong, Yu-An Kuo, Hsin-Chin Li

Keywords(s): Artificial intelligence (AI), Cancer, Diagnostics, Imaging, Machine learning, Medical imaging, Microscopy

Category(s): Life sciences > Imaging > Microscopy, Life sciences > Imaging

Novel Multi-Omics Aging Clock

A multi-omics clock analyzes multiple layers of omics data with machine learning to predict remaining lifespan of mammals, particularly for animal model studies. Large omics data sets may be used from combinations of genomics, proteomics, lipids, etc. available from blood or other simple sample collection. This tool can robustly capture changes...

Published: 3/12/2024 | Inventor(s): George Sutphin, Samuel Freitas, Megha Padi, Chen Chen

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Category(s): Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Simulators and Modeling Tools

Autonomous Drone for railroad track inspection

Reference #: 01564 The University of South Carolina is offering licensing opportunities for Autonomous Drone for railroad track inspection Background: The current practices suffer from three main drawbacks: 1) Human pilot cost is significant. The schedule of the drone-based track inspection is contingent on the pilot’s availability rather than...

Published: 3/15/2023 | Inventor(s): Yu Qian, Yi Wang, Chen Chen

Keywords(s): autonomous drone, flight control, image processing, railroad track inspection, self-navigation

Category(s): Engineering and Physical Sciences

Tetrazole & Coumarin Phosphonate Based Broad-Spectrum Beta-Lactamase Inhibitors

Competitive Advantages Combats bacterial antibiotic resistance to β-Lactamase Effectively inhibits against the different classes of β-Lactamase Enhances effectiveness of current β-lactam antibiotics treatments Summary Our inventors have discovered tetrazole and coumarin phosphonate based compounds can actively inhibit...

Published: 6/27/2024 | Inventor(s): Yu Chen, Orville Pemberton, Adam Renslo, Priyadarshini Jaishankar

Keywords(s): Infectious Diseases Treatment, Pharmaceuticals

Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical

Beta-Lactamase Inhibitor Compositions, Methods of Use, and Methods of Treatment

Competitive Advantages Can restore the efficacy of beta-lactam antibiotics Overcomes antibiotic resistance May help to develop new antibiotic treatment regimens Treats multi-drug resistant organisms Summary Our researchers have developed compositions comprised of a beta-lactamase inhibitor and methods of use to treat various infections and...

Published: 6/27/2024 | Inventor(s): Adam Renslo, Derek Nichols, Priyadarshini Jaishankar, Yu Chen, Erica Lauterwasser

Keywords(s): Infectious Diseases Treatment, Pharmaceuticals

Category(s): Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical

2015-671 Underground Shafts for Hydrogen Storage

SummaryResearchers at UCLA have developed an underground drilled shaft concept for storage of hydrogen or other gases.BackgroundOne challenge in creating a hydrogen economy is developing hydrogen gas storage solutions. Increased interest has helped the global hydrogen storage market grow to $2.6 billion in 2016, and it is expected to reach over $5...

Published: 7/19/2023 | Inventor(s): Adrienne Lavine, Hossein Kavehpour, Dante Simonetti, Richard Wirz, Chen Chen, Gabriela Bran, Gopinath Warrier, Hamarz Aryafar, Jonathon Kennedy, Joshua Jordan, Keith Lovegrove

Keywords(s): Energy & Water

Category(s): Energy & Environment > Energy Generation > Solar, Energy & Environment > Energy Storage

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