Search Results - trung+nguyen

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Enhanced fluorescence via DNA aptamer optimization
This invention improves the fluorescence of DNA-based aptamers by sub­stituting the original fluorophore with TO1-biotin and identifying a critical mutation that further enhances fluorescence. Background Fluorogenic DNA aptamers (FAPs) are a crucial tool in molecular biology, particularly for applications like live-cell imaging and highly specific...
Published: 12/6/2024   |   Inventor(s): Hsin-Chih (Tim) Yeh, Yuan-I Chen, Yu-An Kuo, Yujie He, Trung Nguyen, Soonwoo Hong, Anh-Thu Nguyen, Sohyun Kim, Saeed Seifi
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform
Fluorescence lifetime imaging for retinal function assessment
This invention uses a laser-based imaging system to study the eye’s retina. By measuring light responses, it provides insights into retinal health and potential diseases like age-related macular degeneration. Background Two-photon excited fluorescence (TPEF) is a powerful technique used to study the eye. TPEF allows researchers to excite intrinsic...
Published: 10/24/2024   |   Inventor(s): Hsin-Chih (Tim) Yeh, Trung Nguyen, Yuan-I Chen, H. Grady Rylander, Yu-An Kuo, Soonwoo Hong, Anh-Thu Nguyen, Yujie He
Keywords(s):  
Category(s): Life sciences > Imaging, Life sciences > Imaging > Microscopy
­Low-cost fluorescent reporters for nuclease activity detection
Problem DNA cleavage or nuclease activity detection is important in many forms of nucleic acid amplification tests. The current detection technologies rely on the use of fluorescence resonance energy transfer (FRET) reporters that light up upon digestion, such as the Taqman® probe and the DNaseAlert®. Although these FRET reporters well serve...
Published: 6/6/2024   |   Inventor(s): Hsin-Chih (Tim) Yeh, Soonwoo Hong, Yuan-I Chen, Yu-An Kuo, Trung Nguyen, Hsin-Chin Li
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Agriculture > Animal/veterinary