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Search Results - yang+yang
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High-Potency Biased β2-adrenergic Receptor Agonist for Treating Respiratory Diseases
Advantages Ultra-potent β2-adrenergic receptor agonist that stimulates cAMP production with sub-nanomolar potency (EC50 = 0.25nM) Biased signaling profile selectively activates Gαs-mediated cAMP signaling while avoiding β-arrestin2 recruitment, reducing receptor desensitization characteristic of traditional treatments such as albuterol Maintains...
Published: 5/27/2025
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Inventor(s):
Stephen Liggett
,
Donghwa Kim
,
Yu Chen
,
Jesper Madsen
,
Steven An
Keywords(s):
Pharmaceuticals
,
Respiratory Diseases Treatment
Category(s):
Technology Classifications > Medical > Respiratory
,
Technology Classifications > Medical > Therapeutics
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Technology Classifications > Medical > Pharmaceuticals
Virus-Like Particles for mRNA Delivery
Virus-like particles have been engineered for drug delivery, gene editing applications, mRNA delivery and overcoming barriers in mouse lungs. Background: Recent biomedical research has shown increased interest in the use of virus-like particles as a drug delivery vehicle. Current viral vectors have been shown to cause adverse immunological responses,...
Published: 5/28/2025
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Inventor(s):
Sriram Neelamegham
,
Qi Yang
Keywords(s):
Featured
,
Technologies
Category(s):
Campus > University at Buffalo
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Technology Classifications > Biological Materials
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Technology Classifications > Drug Delivery
,
Technology Classifications > Healthcare
,
Technology Classifications > Gene Therapy
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Technology Classifications > Materials and Chemicals
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Technology Classifications > Research Tools and Reagents
,
Technology Classifications > Screens and Assays
Potent and Selective Inhibition of a Single AMPA Receptor Subunit by an RNA Aptamer
Inhibitors of AMPA type glutamate ion channels for the treatment of neurological disorders such as ALS, Alzheimer's, and Parkinson's. Background: Ionotropic glutamate receptors (iGluRs) play special roles in brain activities, such as memory and learning, and have been implicated in a variety of neurological diseases, such as post-stroke cellular...
Published: 5/13/2025
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Inventor(s):
Li Niu
,
Zhen Huang
,
Yan Han
,
Congzhou Wang
,
Jae Seon Park
Keywords(s):
RNA
,
Technologies
Category(s):
Technology Classifications > Biomedical Science and Engineering
,
Campus
,
Campus > University at Albany
Communication-Efficient Decentralized Multi-agent Machine Learning Method
Background In decentralized machine learning systems, agents often have varying computational and communication resources, leading to straggler problems and inefficient training. Existing federated learning methods typically rely on a central server, creating a bottleneck and limiting scalability in resource-constrained or failure-prone environments. Technology...
Published: 5/6/2025
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Inventor(s):
Lei Yang
,
Seyed Mahmoud Sajjadi Mohammadabadi
Keywords(s):
Category(s):
Technology Classifications > Software
,
Technology Classifications > Information & Communication Technologies
Deep learning-based wildfire smoke detection tools
Technology Overview Researchers at the University of Nevada, Reno have developed an early wildfire smoke detection software that uses AI to analyze real-time video from remote camera networks. The system, named Nemo, uses an end-to-end Transformer architecture (based on DETR) to detect small, low-density smoke plumes—often visible only as faint...
Published: 5/6/2025
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Inventor(s):
Lei Yang
,
Amir Yazdi
Keywords(s):
Category(s):
Technology Classifications > Software
,
Technology Classifications > Energy & Environment
PMU-based event detection tool for grid analytics and monitoring
Technology Overview: Researchers at the University of Nevada, Reno have developed real-time grid event detection software that analyzes phasor measurement unit (PMU) data. The software uses singular value decomposition (SVD) to measure changes in rank signatures across PMU data signals (voltage, current, frequency). It employs Bayesian optimization...
Published: 5/6/2025
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Inventor(s):
Lei Yang
,
Amir Ghasemkhani
,
Yunchuan Liu
Keywords(s):
Category(s):
Technology Classifications > Software
,
Technology Classifications > Energy & Environment
Novel Potential Glaucoma Therapy via Secretome Treatment of Schlemm’s Canal Endothelial Cells
Advantages: Minimally invasive secretome therapy enhances Schlemm’s canal function, offering a non-surgical alternative to glaucoma treatment Secretome therapy promotes cellular repair and wound healing, addressing TM damage beyond Increased Intraocular Pressure (IOP) reduction Secretome therapy enhances aqueous outflow by upregulating tight...
Published: 4/17/2025
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Inventor(s):
Rong Du
,
Yiqin Du
,
Enzhi Yang
Keywords(s):
Ophthalmology
Category(s):
Technology Classifications > Medical > Pharmaceuticals
,
Technology Classifications > Medical
,
Technology Classifications > Chemistry
Novel Real Time Scheduler
THE CHALLENGE Scheduling bandwidth for multiple cell phone users is presently accomplished almost on an arbitrary basis using a predefined algorithms developed to maximize throughput. Since the scheduling frames are updated every 1 ms, this approach has made it virtually impossible to allocate bandwidth in a real-time, on-demand basis, to achieve best...
Published: 4/9/2025
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Inventor(s):
Yan Huang
,
Yiwei Thomas Hou
,
Yongce Chen
Keywords(s):
Category(s):
Technology Classifications > Communication
3DVARIENTVISION: DECODE FUNCTIONAL IMPACTS OF GENETIC VARIANTS BASED ON 3D CHROMATIN
VAlue proposition Deciphering the effects and mechanisms of genetic variants is essential to understand human genetics and further precision medicine. A genetic variant is a permanent change in the nucleotide sequence that makes up a gene, also known as a gene mutation. Mutations can cause diseases or phenotypic changes. Typically, Genome Wide Association...
Published: 4/9/2025
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Inventor(s):
Jianrong Wang
,
Jiaxin Yang
Keywords(s):
Category(s):
Medical
,
Biotechnology
,
Computer Software
Highly Selective and Sensitive Carbon Monoxide Probe
Description This technology is a suite of fluorescent reagents for imaging and quantifying carbon monoxide (CO) in biological samples such as cells, tissue, and blood. Compared to existing methods of CO sensing and quantification for research, these CO detection probes feature CO sensing exclusivity, ultralow background fluorescence, ultrahigh sensitivity,...
Published: 4/8/2025
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Inventor(s):
Binghe Wang
,
Xiaoxiao Yang
Keywords(s):
Category(s):
Diagnostic
,
Research Tool
,
Assay
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