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Exogenous Acetate Formulations for Treating Alcohol Use Disorder and Withdrawal
Advantages Mechanistic Innovation: stabilizes brain energy metabolism and modulates adenosine signaling mechanisms not targeted by current addiction therapies. Targeted Brain Delivery: formulations enable effective acetate transport across the blood-brain barrier, (BBB) Controlled and sustained release Versatile Administration Routes: compatible...
Published: 9/30/2025   |   Inventor(s): Dominic D'Agostino
Keywords(s): Neuroscience, Pharmaceuticals
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Therapeutics, Technology Classifications > Chemistry, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Neuroscience
Fenchol: A Natural Therapeutic for Cognitive Health and Neurodegenerative Care
Advantages Targeting neuroinflammation and proteostasis Strong preclinical efficacy in cells, C. elegans, and Alzheimer’s mouse models GRAS-designated natural compound with excellent safety profile Multiple delivery formats: oral, nasal, buccal, topical, supplement Summary Neurodegenerative diseases such as Alzheimer’s Disease (AD)...
Published: 11/7/2025   |   Inventor(s): Hariom Yadav, Shalini Jain, Sidharth Mishra
Keywords(s): Neurodegenerative Diseases, Neuroscience, Nutrition / Diet Health
Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Neuroscience
Cardiac Dysfunction in Friedreich’s Ataxia: Remodelling of the Cardiac Calcium Handling Machinery
Advantages: This study discovered a potential novel mechanism of cardiac dysfunction in Friedreich's ataxia (FA) by uncovering dysregulation in key calcium-handling proteins and mitochondrial dysfunction The study correlates data from an FA mouse model (FXN-KO) with human clinical manifestations, linking frataxin deficiency to cardiac dysfunction...
Published: 7/11/2025   |   Inventor(s): Bojjibabu Chidipi
Keywords(s): Neurodegenerative Diseases
Category(s): Technology Classifications > Medical > Neuroscience
Conditional Hs3st1/4/5 Mouse Lines for In-vivo Study of Heparan Sulfate (HS)
Advantages: Cell and Stage-specific Cre-loxP mediated ablation of Hs3st1/4/5 First-ever floxed alleles for Hs3st4 and Hs3st5 Captures complex neurological and behavioral phenotypes Evaluates drugs on HS pathways and 3-O-sulfation dependent motifs Summary: Heparan sulfate (HS) is a polysaccharide which plays a vital role in various biological...
Published: 6/26/2025   |   Inventor(s): Lianchun Wang
Keywords(s): Animal Models, Neuroscience
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models, Technology Classifications > Medical > Neuroscience
A Microfluidic-coupled in vitro Model of the Blood-Brain Barrier (BBB)
Advantages Real-time trans endothelial electrical resistance (TEER) monitoring: embedded Ag/AgCl electrodes enables high-resolution impedance spectroscopy, outperforming conventional models Physiologically relevant tri-culture design: microfluidic flow mimics in vivo BBB hemodynamics with spatially separated HUVECs, astrocytes, and pericytes Enhanced...
Published: 6/5/2025   |   Inventor(s): Shyam Mohapatra, Subhra Mohapatra, Tao Wang, Taylor Martinez
Keywords(s):  
Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications, Technology Classifications > Research Tools/Copyright, Technology Classifications > Medical > Neuroscience
A novel mouse model (TRE-HuAmy line) to achieve spatial and temporal control of human amylin transgene expression
Advantages Enables the in vivo switching on or off human amylin expression through the administration/ withdrawal of DOX Spatially restricted transgene activation: crossing tissue-specific rtTA/tTA lines achieves localized amylin expression without off-target effects. Single-copy Rosa26 knock-in for consistent expression: integration at Rosa26...
Published: 6/3/2025   |   Inventor(s): Gopal Thinakaran, Florin Despa
Keywords(s):  
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models, Technology Classifications > Medical > Neuroscience, zzDiabetes
RNA Binding Motif 3 (RBM3) Overexpressing Transgenic Mouse
Advantages RBM3 upregulation reverses multiple tau phosphorylations post-TBI Novel RBM3 Overexpressing Transgenic Mouse Model allows researchers to study the effects of RBM3 activation on tissue function, brain function, and brain injury Summary Traumatic brain injury (TBI) not only causes immediate neuronal damage but also predisposes survivors...
Published: 9/26/2025   |   Inventor(s): Travis Jackson
Keywords(s): Animal Models, Neuroscience
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Biotechnology
Computerized Cognitive Training for Insomnia (COGMUSE)
Advantages Gamified cognitive training that is aimed at adults with both autism and insomnia Flexibility in terms of the ability to incorporate user feedback Summary Older adults with insomnia as well as autistic adults with co-occurring insomnia often struggle with persistent cognitive and sleep disturbances. These issues are only marginally...
Published: 10/14/2025   |   Inventor(s): Ashley Curtis
Keywords(s): Biotechnology, Computer Science, Computers Software and Information Technology, Health Tech, Human Computer Interfaces, Neuroscience, Psychiatry / Mental Health, Therapeutics
Category(s): Technology Classifications > Computer Science > Computers Software & Information Technology, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Therapeutics, Technology Classifications > Engineering > Computer Engineering
Animal Model of Angelman Syndrome
Advantages: Lacks the entire UBE3 gene Removal of all isoforms Removal of all alternate promoters Summary: Angelman Syndrome (AS) is a devastating neurological disorder which affects 1 in every 15,000 people. AS presents with ataxia, frequent smiling, laughter, lack of speech, and severe, debilitating seizures. Epilepsy in AS is often refractory...
Published: 5/12/2025   |   Inventor(s): Edwin Weeber, David Segal, Hennriette O'Geen, Ben Pyles, Scott Dindot
Keywords(s): Animal Models
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models, Technology Classifications > Medical, Technology Classifications > Medical > Neuroscience
Binding Between TREM2 and Heparan Sulfate Delineates the Role of Microglia in AD and Reveals Novel Treatment Strategies
Advantages: Discovered novel structural interactions between HS and TREM2, associated with neurodegeneration High-affinity binding: TREM2 specifically interacts with Heparan Sulfate (HS) modified with 6-O-sulfation and iduronic acid, enabling precise microglial modulation compared to broad-spectrum anti-inflammatory strategies Defined structural...
Published: 10/14/2025   |   Inventor(s): Lianchun Wang, Ilayda McMillan
Keywords(s): Immunology, Neurodegenerative Diseases, Neuroscience
Category(s): zzNeurodegenerative Diseases Treatment, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Therapeutics
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