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YTH Domain-Containing Family Protein 1 (YTHDF1): A Novel Therapeutic Target for Alzheimer’s Disease
Advantages: A novel method for targeting m6A methylation via YTHDF1 offers a potential therapy for tauopathies and Alzheimer’s disease YTHDF1 reduces neuroinflammation in Alzheimer’s disease by downregulating pro-inflammatory genes like Ccl6 and Cst7 Enhance working memory and reduce hyperactivity in tauopathy, suggesting cognitive...
Published: 3/6/2025   |   Inventor(s): Gopal Thinakaran, Shuai Wang
Keywords(s): Animal Models, Neurodegenerative Diseases
Category(s): Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Therapeutics
Gait Rehabilitation: Harnessing Multimodal Rhythmic Asymmetric Sensory Cues
Advantages: Sensory cues improve step length and timing, enhancing walking coordination Combined auditory-tactile cues adapt to individual needs for more effective therapy Braking force and stability improvements reduce fall risks These methods activate neuroplasticity, promoting lasting motor improvements Summary: Tech ID 20B150 and...
Published: 1/31/2025   |   Inventor(s): Seok Kim, Kyle Reed
Keywords(s): Devices for Disabilities / Rehabilitation
Category(s): Technology Classifications > Medical > Medical Devices, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Biomedical Engineering
Gait Rehabilitation: Harnessing Multimodal Rhythmic Asymmetric Sensory Cues
Advantages: Sensory cues improve step length and timing, enhancing walking coordination Combined auditory-tactile cues adapt to individual needs for more effective therapy Braking force and stability improvements reduce fall risks These methods activate neuroplasticity, promoting lasting motor improvements Summary: Tech IDs 20B150 and...
Published: 1/31/2025   |   Inventor(s): Kyle Reed, Seok Kim
Keywords(s): Devices for Disabilities / Rehabilitation
Category(s): Technology Classifications > Medical > Medical Devices, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Biomedical Engineering
Modulating Molecular Chaperone DnaJB6b as a Novel Method to Regulate Tau Seeding and Propagation
­Advantages: Semi-high throughput screening accelerates drug discovery by quickly identifying candidates, reducing time to market, and gaining a competitive edge. Molecular Chaperone reduces tau aggregation, preserving cognitive function and improving patient quality. Employs a precision medicine approach targeting tauopathy mechanisms, potentially...
Published: 9/11/2024   |   Inventor(s): Abigail Esquivel, Laura Blair
Keywords(s): Alzheimer's Disease, Neurodegenerative Diseases
Category(s): Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Therapeutics
Drug-Induced Activation of the Reelin Signaling System
­Advantages: Small, soluble drug with therapeutic potential Independent Reelin signaling pathway activation More able to pass through the BBB than Reelin Summary: The Reelin signaling pathway is an essential component of the developing and adult central nervous systems. The signaling cascade assists with the regulation of developing neurons...
Published: 7/24/2024   |   Inventor(s): Edwin Weeber, Melinda Peters, Qingyou Li, Hana Soueidan
Keywords(s):  
Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Neuroscience
The Sudden Head Acceleration & Kinetic Encephalopathy (SHAKEn™) Device for Preclinical Modeling of Rotational Brain Injury
­Advantages: User control to adjust the positioning of the body plate (in the x/y plane) to optimize spinal alignment relative to the axis of rotation prior to insult. An aeronautics-grade angular rate sensor for direct measurement of angular velocity and to calculate rotational acceleration of the head. An electric plug to power accelerations...
Published: 7/18/2024   |   Inventor(s): Travis Jackson
Keywords(s): Animal Models, Lab Apparatus, Laboratory Devices, Neuroscience, Research Tools
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Medical Devices, Technology Classifications > Medical > Neuroscience
Novel Helical Peptodomimetics that Prevent the Formation of Aβ Oligomerization in Alzheimer’s Disease (AD)
­Advantages: Developed sulfonyl-γ-AA peptide helical peptidomimetics that can prevent the formation of neurotoxic Aβ oligomerization. High Specificity: The lead sulfonyl-γ-AApeptide helical foldamer, Ab-6, exhibits precise targeting to the central region of Aβ42 and induces α-helix conformation in Aβ. Sequence-Specific...
Published: 2/19/2025   |   Inventor(s): Jianfeng Cai, Heng Liu
Keywords(s): Alzheimer's Disease, Biotechnology, Neurodegenerative Diseases
Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Neuroscience
New Device Material for a Flexible Chronic Implantable Neural Interface
­Advantages: Superior biocompatibility reduces immune responses. Excellent electrical conductivity enhances signal transmission. Exceptional mechanical strength enables durable and flexible probes. Summary: Implantable neural interfaces (INIs) are devices configured to connect with the human nervous system through electrical means. Such...
Published: 9/3/2024   |   Inventor(s): Stephen Saddow, Chenyin Feng, Christopher Frewin
Keywords(s): Drug Delivery and Nanomedicine, Medical Therapeutics Cell Therapy, Nanotechnology, Neurodegenerative Diseases
Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Biomaterials, Technology Classifications > Medical > Medical Devices, Technology Classifications > Medical > Neuroscience
Secreted UBE3A for the Treatment of Neurological Disorders
­Advantages: Novel vector, composition, and method of treating a neurological disorder with UBE3A deficiency. High fidelity to human Angelman syndrome. Facilitates comprehensive symptom representation for diverse treatment investigations. Allows innovative experiments for pioneering treatment development. Summary: Angelman...
Published: 2/27/2025   |   Inventor(s): Kevin Nash
Keywords(s): Animal Models, Medical Therapeutics Gene Therapy, Neurodegenerative Diseases, Neuroscience
Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Neuroscience
Conditional FKBP51 Over-expression Transgenic Mouse
­Advantages: Created a transgenic mice model that allows researchers to precisely control the expression of human FKBP51. Offers a tailored approach to studying psychiatric disorders, enabling the development of personalized treatments. Enhances the understanding of the molecular mechanisms underlying psychiatric disorders such as depression,...
Published: 11/13/2024   |   Inventor(s): Chad Dickey(VA) (DECEASED - See Notes), Laura Blair, Bo Zhang
Keywords(s): Animal Models, Psychiatry / Mental Health
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Therapeutics
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