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Conditional Hs3st1/4/5 Mouse Lines for In-vivo Study of Heparan Sulfate (HS)
Advantages: Cell and Stage-specific Cre-loxP mediated ablation of Hs3st1/4/5 First-ever floxed alleles for Hs3st4 and Hs3st5 Captures complex neurological and behavioral phenotypes Evaluates drugs on HS pathways and 3-O-sulfation dependent motifs Summary: Heparan sulfate (HS) is a polysaccharide which plays a vital role in various biological...
Published: 6/26/2025   |   Inventor(s): Lianchun Wang
Keywords(s): Animal Models, Neuroscience
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models, Technology Classifications > Medical > Neuroscience
A Microfluidic-coupled in vitro Model of the Blood-Brain Barrier (BBB)
Advantages Real-time trans endothelial electrical resistance (TEER) monitoring: embedded Ag/AgCl electrodes enables high-resolution impedance spectroscopy, outperforming conventional models Physiologically relevant tri-culture design: microfluidic flow mimics in vivo BBB hemodynamics with spatially separated HUVECs, astrocytes, and pericytes Enhanced...
Published: 6/5/2025   |   Inventor(s): Shyam Mohapatra, Subhra Mohapatra, Tao Wang, Taylor Martinez
Keywords(s):  
Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications, Technology Classifications > Research Tools/Copyright, Technology Classifications > Medical > Neuroscience
A novel mouse model (TRE-HuAmy line) to achieve spatial and temporal control of human amylin transgene expression
Advantages Enables the in vivo switching on or off human amylin expression through the administration/ withdrawal of DOX Spatially restricted transgene activation: crossing tissue-specific rtTA/tTA lines achieves localized amylin expression without off-target effects. Single-copy Rosa26 knock-in for consistent expression: integration at Rosa26...
Published: 6/3/2025   |   Inventor(s): Gopal Thinakaran, Florin Despa
Keywords(s):  
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models, Technology Classifications > Medical > Neuroscience, zzDiabetes
Neuromapping Depth Electrode
Advantages Combines recording and stimulation in a single device Reduces brain penetration and surgery time Lowers risk of hemorrhage, infection, and brain shift Enables precise brain mapping and real-time stimulation Summary Deep Brain Stimulation (DBS) helps patients with movement disorders like Parkinson’s disease by sending electrical...
Published: 6/6/2025   |   Inventor(s): Oliver Flouty, Yarema Bezchlibnyk, Vishal Bharmauria, Nour Shaheen, Brian Dalm, Can Sarica, Matthew Howard, Hiroto Kawasaki, Mario Zanaty, Alex Green, Andres Lozano
Keywords(s):  
Category(s): Technology Classifications > Medical > Neuroscience
RNA Binding Motif 3 (RBM3) Overexpressing Transgenic Mouse
Advantages • RBM3 upregulation reverses multiple tau phosphorylations post-TBI • Novel RBM3 Overexpressing Transgenic Mouse Model allows researchers to study the effects of RBM3 activation on tissue function, brain function, and brain injury Summary Traumatic brain injury (TBI) not only causes immediate neuronal damage but also...
Published: 5/30/2025   |   Inventor(s): Travis Jackson
Keywords(s): Animal Models, Neuroscience
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Biotechnology
Computerized Cognitive Training for Insomnia (COGMUSE)
Advantages Gamified cognitive training that is aimed at adults with both autism and insomnia Flexibility in terms of the ability to incorporate user feedback Summary Older adults with insomnia as well as autistic adults with co-occurring insomnia often struggle with persistent cognitive and sleep disturbances. These issues are only marginally...
Published: 5/30/2025   |   Inventor(s): Ashley Curtis
Keywords(s): Biotechnology, Computer Science, Computers Software and Information Technology, Health Tech, Human Computer Interfaces, Neuroscience, Psychiatry / Mental Health, Therapeutics
Category(s): Technology Classifications > Computer Science > Computers Software & Information Technology, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Therapeutics, Technology Classifications > Engineering > Computer Engineering
Treating Covid-19 Infection-Induced Dementia
Advantages: Novel gene therapy targeting FKBP5 and IFI204 to disrupt tauopathy-related signaling Targeted RNA delivery utilizing dendriplex nanoparticles to silence SARS-CoV-2 induced neurodegenerative pathways Preclinical animal studies indicate reduction of neuroinflammation and tau accumulation Intranasal delivery bypasses the blood-brain...
Published: 5/27/2025   |   Inventor(s): Subhra Mohapatra, Shyam Mohapatra, Karthick Mayilsamy
Keywords(s): Covid-19, Neuroscience
Category(s): Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Therapeutics
3D Printed Robot-Assisted Alignment Tool for Multiple Intracranial Surgical Trajectories
Advantages Tailored 3D-printed alignment guides enhance precision in electrode placement, minimizing errors and improving surgical outcomes in epilepsy procedures Reduces surgical time and associated risks by eliminating the need for sequential robotic arm movements, streamlining the procedure Avoiding pre-surgery procedures like skull screws...
Published: 5/9/2025   |   Inventor(s): Elliot Neal
Keywords(s):  
Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Neuroscience, Technology Classifications > Engineering > Electrical Engineering, Technology Classifications > Engineering > Computer Engineering
Animal Model of Angelman Syndrome
Advantages: Lacks the entire UBE3 gene Removal of all isoforms Removal of all alternate promoters Summary: Angelman Syndrome (AS) is a devastating neurological disorder which affects 1 in every 15,000 people. AS presents with ataxia, frequent smiling, laughter, lack of speech, and severe, debilitating seizures. Epilepsy in AS is often refractory...
Published: 5/12/2025   |   Inventor(s): Edwin Weeber, David Segal, Hennriette O'Geen, Ben Pyles, Scott Dindot
Keywords(s): Animal Models
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models, Technology Classifications > Medical, Technology Classifications > Medical > Neuroscience
TREM2 Binds to Specifically Structured Heparan Sulfate
Advantages: Discovered novel structural interactions between HS and TREM2, associated with neurodegeneration High-affinity binding: TREM2 specifically interacts with Heparan Sulfate (HS) modified with 6-O-sulfation and iduronic acid, enabling precise microglial modulation compared to broad-spectrum anti-inflammatory strategies Defined structural...
Published: 5/29/2025   |   Inventor(s): Lianchun Wang, Ilayda McMillan
Keywords(s): Immunology, Neurodegenerative Diseases, Neuroscience
Category(s): zzNeurodegenerative Diseases Treatment, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Therapeutics
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