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Treating Covid-19 Infection-Induced Dementia
Advantages: Novel gene therapy targeting FKBP5 and IFI204 to disrupt tauopathy-related signaling Targeted RNA delivery utilizing dendriplex nanoparticles to silence SARS-CoV-2 induced neurodegenerative pathways Preclinical animal studies indicate reduction of neuroinflammation and tau accumulation Intranasal delivery bypasses the blood-brain...
Published: 5/27/2025   |   Inventor(s): Subhra Mohapatra, Shyam Mohapatra, Karthick Mayilsamy
Keywords(s): Covid-19, Neuroscience
Category(s): Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Therapeutics
3D Printed Robot-Assisted Alignment Tool for Multiple Intracranial Surgical Trajectories
Advantages Tailored 3D-printed alignment guides enhance precision in electrode placement, minimizing errors and improving surgical outcomes in epilepsy procedures Reduces surgical time and associated risks by eliminating the need for sequential robotic arm movements, streamlining the procedure Avoiding pre-surgery procedures like skull screws...
Published: 5/9/2025   |   Inventor(s): Elliot Neal
Keywords(s):  
Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Neuroscience, Technology Classifications > Engineering > Electrical Engineering, Technology Classifications > Engineering > Computer Engineering
Animal Model of Angelman Syndrome
Advantages: Lacks the entire UBE3 gene Removal of all isoforms Removal of all alternate promoters Summary: Angelman Syndrome (AS) is a devastating neurological disorder which affects 1 in every 15,000 people. AS presents with ataxia, frequent smiling, laughter, lack of speech, and severe, debilitating seizures. Epilepsy in AS is often refractory...
Published: 5/12/2025   |   Inventor(s): Edwin Weeber, David Segal, Hennriette O'Geen, Ben Pyles, Scott Dindot
Keywords(s): Animal Models
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models, Technology Classifications > Medical, Technology Classifications > Medical > Neuroscience
TREM2 Binds to Specifically Structured Heparan Sulfate
Advantages: Discovered novel structural interactions between HS and TREM2, associated with neurodegeneration High-affinity binding: TREM2 specifically interacts with Heparan Sulfate (HS) modified with 6-O-sulfation and iduronic acid, enabling precise microglial modulation compared to broad-spectrum anti-inflammatory strategies Defined structural...
Published: 5/29/2025   |   Inventor(s): Lianchun Wang, Ilayda McMillan
Keywords(s): Immunology, Neurodegenerative Diseases, Neuroscience
Category(s): zzNeurodegenerative Diseases Treatment, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Therapeutics
YTH Domain-Containing Family Protein 1 (YTHDF1): A Novel Therapeutic Target for Alzheimer’s Disease
Advantages: A novel method for targeting m6A methylation via YTHDF1 offers a potential therapy for tauopathies and Alzheimer’s disease YTHDF1 reduces neuroinflammation in Alzheimer’s disease by downregulating pro-inflammatory genes like Ccl6 and Cst7 Enhance working memory and reduce hyperactivity in tauopathy, suggesting cognitive...
Published: 5/11/2025   |   Inventor(s): Gopal Thinakaran, Shuai Wang
Keywords(s): Animal Models, Neurodegenerative Diseases
Category(s): Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Therapeutics, Technology Classifications > Computer Science
Gait Rehabilitation: Harnessing Multimodal Rhythmic Asymmetric Sensory Cues
Advantages: Sensory cues improve step length and timing, enhancing walking coordination Combined auditory-tactile cues adapt to individual needs for more effective therapy Braking force and stability improvements reduce fall risks These methods activate neuroplasticity, promoting lasting motor improvements Summary: Tech ID 20B150 and...
Published: 1/31/2025   |   Inventor(s): Seok Kim, Kyle Reed
Keywords(s): Devices for Disabilities / Rehabilitation
Category(s): Technology Classifications > Medical > Medical Devices, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Biomedical Engineering
Gait Rehabilitation: Harnessing Multimodal Rhythmic Asymmetric Sensory Cues
Advantages: Sensory cues improve step length and timing, enhancing walking coordination Combined auditory-tactile cues adapt to individual needs for more effective therapy Braking force and stability improvements reduce fall risks These methods activate neuroplasticity, promoting lasting motor improvements Summary: Tech IDs 20B150 and...
Published: 1/31/2025   |   Inventor(s): Kyle Reed, Seok Kim
Keywords(s): Devices for Disabilities / Rehabilitation
Category(s): Technology Classifications > Medical > Medical Devices, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Biomedical Engineering
Modulating Molecular Chaperone DnaJB6b as a Novel Method to Regulate Tau Seeding and Propagation
­Advantages: Semi-high throughput screening accelerates drug discovery by quickly identifying candidates, reducing time to market, and gaining a competitive edge. Molecular Chaperone reduces tau aggregation, preserving cognitive function and improving patient quality. Employs a precision medicine approach targeting tauopathy mechanisms, potentially...
Published: 9/11/2024   |   Inventor(s): Abigail Esquivel, Laura Blair
Keywords(s): Alzheimer's Disease, Neurodegenerative Diseases
Category(s): Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Therapeutics
Drug-Induced Activation of the Reelin Signaling System
­Advantages: Small, soluble drug with therapeutic potential Independent Reelin signaling pathway activation More able to pass through the BBB than Reelin Summary: The Reelin signaling pathway is an essential component of the developing and adult central nervous systems. The signaling cascade assists with the regulation of developing neurons...
Published: 7/24/2024   |   Inventor(s): Edwin Weeber, Melinda Peters, Qingyou Li, Hana Soueidan
Keywords(s):  
Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Neuroscience
The Sudden Head Acceleration & Kinetic Encephalopathy (SHAKEn™) Device for Preclinical Modeling of Rotational Brain Injury
­Advantages: User control to adjust the positioning of the body plate (in the x/y plane) to optimize spinal alignment relative to the axis of rotation prior to insult. An aeronautics-grade angular rate sensor for direct measurement of angular velocity and to calculate rotational acceleration of the head. An electric plug to power accelerations...
Published: 7/18/2024   |   Inventor(s): Travis Jackson
Keywords(s): Animal Models, Lab Apparatus, Laboratory Devices, Neuroscience, Research Tools
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Medical Devices, Technology Classifications > Medical > Neuroscience
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