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M4 Foldamer Peptidomimetic: Targeting Amyloid-beta (Aβ) Aggregation to Restore Neuronal Function in Alzheimer’s Disease
Adantages Enhanced Blood-Brain Barrier (BBB) Penetration allows for efficient therapeutic targeting Superior serum stability enables a longer therapeutic window compared to conventional peptide therapeutics Multimodal therapeutic mechanism simultaneously addresses multiple pathological hallmarks of Alzheimer’s Disease (AD) Summary Alzheimer’s...
Published: 8/11/2025   |   Inventor(s): Jianfeng Cai, Heng Liu, Donghui Zhu, Firoz Akhter
Keywords(s): Alzheimer's Disease, Neurodegenerative Diseases, Therapeutics
Category(s): zzNeurodegenerative Diseases Treatment, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Therapeutics
Fenchol: A Natural Therapeutic for Cognitive Health and Neurodegenerative Care
Advantages Targeting neuroinflammation and proteostasis Strong preclinical efficacy in cells, C. elegans, and Alzheimer’s mouse models GRAS-designated natural compound with excellent safety profile Multiple delivery formats: oral, nasal, buccal, topical, supplement Summary Neurodegenerative diseases such as Alzheimer’s Disease (AD)...
Published: 8/4/2025   |   Inventor(s): Hariom Yadav, Shalini Jain, Sidharth Mishra
Keywords(s): Neurodegenerative Diseases, Neuroscience, Nutrition / Diet Health
Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Neuroscience
Cardiac Dysfunction in Friedreich’s Ataxia: Remodelling of the Cardiac Calcium Handling Machinery
Advantages: This study discovered a potential novel mechanism of cardiac dysfunction in Friedreich's ataxia (FA) by uncovering dysregulation in key calcium-handling proteins and mitochondrial dysfunction The study correlates data from an FA mouse model (FXN-KO) with human clinical manifestations, linking frataxin deficiency to cardiac dysfunction...
Published: 7/11/2025   |   Inventor(s): Bojjibabu Chidipi
Keywords(s): Neurodegenerative Diseases
Category(s): Technology Classifications > Medical > Neuroscience
Conditional Hs3st1/4/5 Mouse Lines for In-vivo Study of Heparan Sulfate (HS)
Advantages: Cell and Stage-specific Cre-loxP mediated ablation of Hs3st1/4/5 First-ever floxed alleles for Hs3st4 and Hs3st5 Captures complex neurological and behavioral phenotypes Evaluates drugs on HS pathways and 3-O-sulfation dependent motifs Summary: Heparan sulfate (HS) is a polysaccharide which plays a vital role in various biological...
Published: 6/26/2025   |   Inventor(s): Lianchun Wang
Keywords(s): Animal Models, Neuroscience
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models, Technology Classifications > Medical > Neuroscience
A Microfluidic-coupled in vitro Model of the Blood-Brain Barrier (BBB)
Advantages Real-time trans endothelial electrical resistance (TEER) monitoring: embedded Ag/AgCl electrodes enables high-resolution impedance spectroscopy, outperforming conventional models Physiologically relevant tri-culture design: microfluidic flow mimics in vivo BBB hemodynamics with spatially separated HUVECs, astrocytes, and pericytes Enhanced...
Published: 6/5/2025   |   Inventor(s): Shyam Mohapatra, Subhra Mohapatra, Tao Wang, Taylor Martinez
Keywords(s):  
Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications, Technology Classifications > Research Tools/Copyright, Technology Classifications > Medical > Neuroscience
A novel mouse model (TRE-HuAmy line) to achieve spatial and temporal control of human amylin transgene expression
Advantages Enables the in vivo switching on or off human amylin expression through the administration/ withdrawal of DOX Spatially restricted transgene activation: crossing tissue-specific rtTA/tTA lines achieves localized amylin expression without off-target effects. Single-copy Rosa26 knock-in for consistent expression: integration at Rosa26...
Published: 6/3/2025   |   Inventor(s): Gopal Thinakaran, Florin Despa
Keywords(s):  
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models, Technology Classifications > Medical > Neuroscience, zzDiabetes
Neuromapping Depth Electrode
Advantages Combines recording and stimulation in a single device Reduces brain penetration and surgery time Lowers risk of hemorrhage, infection, and brain shift Enables precise brain mapping and real-time stimulation Summary Deep Brain Stimulation (DBS) helps patients with movement disorders like Parkinson’s disease by sending electrical...
Published: 6/6/2025   |   Inventor(s): Oliver Flouty, Yarema Bezchlibnyk, Vishal Bharmauria, Nour Shaheen, Brian Dalm, Can Sarica, Matthew Howard, Hiroto Kawasaki, Mario Zanaty, Alex Green, Andres Lozano
Keywords(s):  
Category(s): Technology Classifications > Medical > Neuroscience
RNA Binding Motif 3 (RBM3) Overexpressing Transgenic Mouse
Advantages • RBM3 upregulation reverses multiple tau phosphorylations post-TBI • Novel RBM3 Overexpressing Transgenic Mouse Model allows researchers to study the effects of RBM3 activation on tissue function, brain function, and brain injury Summary Traumatic brain injury (TBI) not only causes immediate neuronal damage but also...
Published: 5/30/2025   |   Inventor(s): Travis Jackson
Keywords(s): Animal Models, Neuroscience
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Biotechnology
Computerized Cognitive Training for Insomnia (COGMUSE)
Advantages Gamified cognitive training that is aimed at adults with both autism and insomnia Flexibility in terms of the ability to incorporate user feedback Summary Older adults with insomnia as well as autistic adults with co-occurring insomnia often struggle with persistent cognitive and sleep disturbances. These issues are only marginally...
Published: 7/17/2025   |   Inventor(s): Ashley Curtis
Keywords(s): Biotechnology, Computer Science, Computers Software and Information Technology, Health Tech, Human Computer Interfaces, Neuroscience, Psychiatry / Mental Health, Therapeutics
Category(s): Technology Classifications > Computer Science > Computers Software & Information Technology, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Therapeutics, Technology Classifications > Engineering > Computer Engineering
Treating Covid-19 Infection-Induced Dementia
Advantages: Novel gene therapy targeting FKBP5 and IFI204 to disrupt tauopathy-related signaling Targeted RNA delivery utilizing dendriplex nanoparticles to silence SARS-CoV-2 induced neurodegenerative pathways Preclinical animal studies indicate reduction of neuroinflammation and tau accumulation Intranasal delivery bypasses the blood-brain...
Published: 5/27/2025   |   Inventor(s): Subhra Mohapatra, Shyam Mohapatra, Karthick Mayilsamy
Keywords(s): Covid-19, Neuroscience
Category(s): Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Therapeutics
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