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From Muscle to Mind: Harnessing the Muscle–Brain Axis with Scalable, Muscle-Derived Extracellular Vesicles to Treat Alzheimer’s Disease
Advantages Harnesses the muscle-brain axis, turning human muscle progenitor cells into a renewable source of brain-targeting therapeutic vesicles. Enables scalable, high-yield vesicle production in a compact bioreactor system. Uses a fully xeno-free process for safer, clinically ready, biocompatible manufacturing. Crosses the blood-brain barrier...
Published: 7/15/2026   |   Updated: 7/15/2026   |   Inventor(s): Wanling Xuan, Yao Yao
Keywords(s): Alzheimer's Disease
Category(s): Technology Classifications > Medical > Neuroscience
Flexible Conductive Dry Electrode
Advantages Delivers reliable, high-quality signals with minimal noise and movement interference Eliminates gels and fluids, reducing setup time to under five minutes Soft, flexible materials conform to the scalp comfortably during extended wear Highly durable and reusable, lowering long-term costs and reducing medical waste Summary EEG technology...
Published: 6/24/2026   |   Updated: 6/22/2026   |   Inventor(s): Katherine Walters, Bridget Clift, Souheil Zekri, Addison Whitehead, Albert Kim, Alex Otten, Cristina Ramirez-Vargas, Nathan Schilaty
Keywords(s): Medical Diagnostics, Neuroscience, Wearable Electronics, Wearable Monitoring Equipment
Category(s): Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Medical Diagnostics
ICA‑1S and ζ‑Stat: Selective aPKC Inhibitors for Anti‑Angiogenic Control Neuroblastoma
Advantages Upstream pathway control: Suppresses VEGF‑A by targeting aPKC, a master regulator of angiogenic signaling. Selective, small-molecule mechanism: offers lower immunogenicity and easier development than antibody-based therapies. Combination-therapy ready: upstream angiogenic pathway control enables synergy with existing treatments. Summary Neuroblastoma...
Published: 7/9/2026   |   Updated: 2/16/2026   |   Inventor(s): Sloan Breedy, Wishrawana Ratnayake, Mildred Acevedo-Duncan
Keywords(s): Cancer Treatment, Small Molecules
Category(s): Technology Classifications > Cancer, Technology Classifications > Chemistry, Technology Classifications > Medical > Oncology, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals
Exogenous Acetate Formulations for Treating Alcohol Use Disorder and Withdrawal
Advantages Mechanistic Innovation: stabilizes brain energy metabolism and modulates adenosine signaling mechanisms not targeted by current addiction therapies. Targeted Brain Delivery: formulations enable effective acetate transport across the blood-brain barrier, (BBB) Controlled and sustained release Versatile Administration Routes: compatible...
Published: 7/13/2026   |   Updated: 9/30/2025   |   Inventor(s): Dominic D'Agostino
Keywords(s): Neuroscience, Pharmaceuticals
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Therapeutics, Technology Classifications > Chemistry, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Neuroscience
Fenchol: A Natural Therapeutic for Cognitive Health and Neurodegenerative Care
Advantages Targeting neuroinflammation and proteostasis Strong preclinical efficacy in cells, C. elegans, and Alzheimer’s mouse models GRAS-designated natural compound with excellent safety profile Multiple delivery formats: oral, nasal, buccal, topical, supplement Summary Neurodegenerative diseases such as Alzheimer’s Disease (AD)...
Published: 6/22/2026   |   Updated: 7/11/2025   |   Inventor(s): Hariom Yadav, Shalini Jain, Sidharth Mishra
Keywords(s): Neurodegenerative Diseases, Neuroscience, Nutrition / Diet Health
Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Neuroscience
Cardiac Dysfunction in Friedreich’s Ataxia: Remodelling of the Cardiac Calcium Handling Machinery
Advantages: This study discovered a potential novel mechanism of cardiac dysfunction in Friedreich's ataxia (FA) by uncovering dysregulation in key calcium-handling proteins and mitochondrial dysfunction The study correlates data from an FA mouse model (FXN-KO) with human clinical manifestations, linking frataxin deficiency to cardiac dysfunction...
Published: 6/22/2026   |   Updated: 7/11/2025   |   Inventor(s): Bojjibabu Chidipi
Keywords(s): Neurodegenerative Diseases
Category(s): Technology Classifications > Medical > Neuroscience
Conditional Hs3st1/4/5 Mouse Lines for In-vivo Study of Heparan Sulfate (HS)
Advantages: Cell and Stage-specific Cre-loxP mediated ablation of Hs3st1/4/5 First-ever floxed alleles for Hs3st4 and Hs3st5 Captures complex neurological and behavioral phenotypes Evaluates drugs on HS pathways and 3-O-sulfation dependent motifs Summary: Heparan sulfate (HS) is a polysaccharide which plays a vital role in various biological...
Published: 6/22/2026   |   Updated: 6/26/2025   |   Inventor(s): Lianchun Wang
Keywords(s): Animal Models, Neuroscience
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models, Technology Classifications > Medical > Neuroscience
A Microfluidic-coupled in vitro Model of the Blood-Brain Barrier (BBB)
Advantages Real-time trans endothelial electrical resistance (TEER) monitoring: embedded Ag/AgCl electrodes enables high-resolution impedance spectroscopy, outperforming conventional models Physiologically relevant tri-culture design: microfluidic flow mimics in vivo BBB hemodynamics with spatially separated HUVECs, astrocytes, and pericytes Enhanced...
Published: 6/22/2026   |   Updated: 6/5/2025   |   Inventor(s): Shyam Mohapatra, Subhra Mohapatra, Tao Wang, Taylor Martinez
Keywords(s):  
Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications, Technology Classifications > Research Tools/Copyright, Technology Classifications > Medical > Neuroscience
A novel mouse model (TRE-HuAmy line) to achieve spatial and temporal control of human amylin transgene expression
Advantages Enables the in vivo switching on or off human amylin expression through the administration/ withdrawal of DOX Spatially restricted transgene activation: crossing tissue-specific rtTA/tTA lines achieves localized amylin expression without off-target effects. Single-copy Rosa26 knock-in for consistent expression: integration at Rosa26...
Published: 6/22/2026   |   Updated: 6/3/2025   |   Inventor(s): Gopal Thinakaran, Florin Despa
Keywords(s):  
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models, Technology Classifications > Medical > Neuroscience, zzDiabetes
RNA Binding Motif 3 (RBM3) Overexpressing Transgenic Mouse
Advantages RBM3 upregulation reverses multiple tau phosphorylations post-TBI Novel RBM3 Overexpressing Transgenic Mouse Model allows researchers to study the effects of RBM3 activation on tissue function, brain function, and brain injury Summary Traumatic brain injury (TBI) not only causes immediate neuronal damage but also predisposes survivors...
Published: 6/22/2026   |   Updated: 5/30/2025   |   Inventor(s): Travis Jackson
Keywords(s): Animal Models, Neuroscience
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Biotechnology
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