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Modulating Molecular Chaperone DnaJB6b as a Novel Method to Regulate Tau Seeding and Propagation

Advantages: Semi-high throughput screening accelerates drug discovery by quickly identifying candidates, reducing time to market, and gaining a competitive edge. Molecular Chaperone reduces tau aggregation, preserving cognitive function and improving patient quality. Employs a precision medicine approach targeting tauopathy mechanisms, potentially...

Published: 9/11/2024 | Inventor(s): Abigail Esquivel, Laura Blair

Keywords(s): Alzheimer's Disease, Neurodegenerative Diseases

Category(s): Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Therapeutics

Drug-Induced Activation of the Reelin Signaling System

Advantages: Small, soluble drug with therapeutic potential Independent Reelin signaling pathway activation More able to pass through the BBB than Reelin Summary: The Reelin signaling pathway is an essential component of the developing and adult central nervous systems. The signaling cascade assists with the regulation of developing neurons...

Published: 7/24/2024 | Inventor(s): Edwin Weeber, Melinda Peters, Qingyou Li, Hana Soueidan

Keywords(s):

Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Neuroscience

The Sudden Head Acceleration & Kinetic Encephalopathy (SHAKEn™) Device for Preclinical Modeling of Rotational Brain Injury

Advantages: User control to adjust the positioning of the body plate (in the x/y plane) to optimize spinal alignment relative to the axis of rotation prior to insult. An aeronautics-grade angular rate sensor for direct measurement of angular velocity and to calculate rotational acceleration of the head. An electric plug to power accelerations...

Published: 7/18/2024 | Inventor(s): Travis Jackson

Keywords(s): Animal Models, Lab Apparatus, Laboratory Devices, Neuroscience, Research Tools

Category(s): Technology Classifications > Research Tools/Copyright > Animal Models, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Medical Devices, Technology Classifications > Medical > Neuroscience

Novel Helical Peptodomimetics that Prevent the Formation of Aβ Oligomerization in Alzheimer’s Disease (AD)

Advantages: Developed sulfonyl-γ-AA peptide helical peptidomimetics that can prevent the formation of neurotoxic Aβ oligomerization. High Specificity: The lead sulfonyl-γ-AApeptide helical foldamer, Ab-6, exhibits precise targeting to the central region of Aβ42 and induces α-helix conformation in Aβ. Sequence-Specific...

Published: 9/12/2024 | Inventor(s): Jianfeng Cai, Heng Liu

Keywords(s): Alzheimer's Disease, Biotechnology, Neurodegenerative Diseases

Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Neuroscience

New Device Material for a Flexible Chronic Implantable Neural Interface

Advantages: Superior biocompatibility reduces immune responses. Excellent electrical conductivity enhances signal transmission. Exceptional mechanical strength enables durable and flexible probes. Summary: Implantable neural interfaces (INIs) are devices configured to connect with the human nervous system through electrical means. Such...

Published: 9/3/2024 | Inventor(s): Stephen Saddow, Chenyin Feng, Christopher Frewin

Keywords(s): Drug Delivery and Nanomedicine, Medical Therapeutics Cell Therapy, Nanotechnology, Neurodegenerative Diseases

Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Biomaterials, Technology Classifications > Medical > Medical Devices, Technology Classifications > Medical > Neuroscience

Secreted UBE3A for the Treatment of Neurological Disorders

Advantages: Novel vector, composition, and method of treating a neurological disorder with UBE3A deficiency. High fidelity to human Angelman syndrome. Facilitates comprehensive symptom representation for diverse treatment investigations. Allows innovative experiments for pioneering treatment development. Summary: Angelman...

Published: 1/2/2024 | Inventor(s): Kevin Nash

Keywords(s): Animal Models, Medical Therapeutics Gene Therapy, Neurodegenerative Diseases, Neuroscience

Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Neuroscience

Conditional FKBP51 Over-expression Transgenic Mouse

Advantages: Created a transgenic mice model that allows researchers to precisely control the expression of human FKBP51. Offers a tailored approach to studying psychiatric disorders, enabling the development of personalized treatments. Enhances the understanding of the molecular mechanisms underlying psychiatric disorders such as depression,...

Published: 9/3/2024 | Inventor(s): Chad Dickey(VA) (DECEASED - See Notes), Laura Blair, Bo Zhang

Keywords(s): Animal Models, Psychiatry / Mental Health

Category(s): Technology Classifications > Research Tools/Copyright > Animal Models, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Therapeutics

Investigating the Role of BIN1's SH3 Domain in Alzheimer's Desease

Advantages: The approach of targeting BIN1, a gene associated with AD increases the likelihood of finding effective therapeutic interventions. Determining the crystal structure of BIN1's SH3 domain provides detailed structural information which is crucial for designing small molecule inhibitors. The research reports promising preliminary...

Published: 1/23/2024 | Inventor(s): Gopal Thinakaran

Keywords(s): Medical Therapeutics Gene Therapy, Neurodegenerative Diseases, Neuroscience, Small Molecules

Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Medical Diagnostics

Novel small molecule targeting lncRNA in neurodegenerative diseases and tauopathies

Advantages: Developed lead compound #67 to elevate GAS5 levels and also enhances neuronal insulin signaling, offering a comprehensive approach to neurodegenerative complexities. Noninvasive Insights: GAS5's presence as a serum biomarker enables noninvasive disease assessment and NPC86 treatment efficacy confirmation. Compound #67's...

Published: 3/14/2024 | Inventor(s): Niketa Patel, Jianfeng Cai

Keywords(s): Medical Therapeutics Gene Therapy, Neurodegenerative Diseases

Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Neuroscience

Exploring Choroid Plexus Senescence as a Potential Link Between COVID-19 and Alzheimer's Disease

Advantages: Advances viral neurology research by studying SARS-CoV-2's impact on the aging brain's choroid plexus. Identifies potential biomarkers for neurodegenerative diseases through cellular senescence and SASP factor analysis. Informs public health strategies regarding COVID-19-related neurological complications and preventive...

Published: 5/9/2024 | Inventor(s): Eleni Markoutsa, Shyam Mohapatra, Subhra Mohapatra

Keywords(s): Infectious Diseases, Neurodegenerative Diseases, Therapeutics

Category(s): Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Therapeutics

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