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Novel Method to Treat Heart Disease in Duchenne Muscular Dystrophy (DMD) Patients

Advantages: Novel Therapeutic target to treat cardiac dystrophy in DMD: Nox4 Inhibition Potential to reduce fibrosis and improve cardiac function over conventional treatments Potential to combine NOX4 inhibition with dystrophin replacement therapies Summary: Duchenne Muscular Dystrophy (DMD) is a genetic disorder caused by mutations in the...

Published: 4/1/2025 | Inventor(s): DaZhi Wang, Zhanpeng Huang, Jianming Liu

Keywords(s): Cardiological Diseases Treatment

Category(s): Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Therapeutics

Brain Cancer: Novel Prognostic Method and Therapeutic Target for Glioblastoma

Advantages: A precision-guided method for identifying glioblastoma-related genes that improves assessment of the current prognostic biomarker Enables the identification of potential novel therapeutic targets: GLP1R agonists, which are already used for managing obesity and type 2 diabetes, could be explored as treatments for GBM Broader Applications:...

Published: 3/24/2025 | Inventor(s): George Blanck, Teresa Thomas

Keywords(s): Cancer Diagnostics, Medical Diagnostics, Oncology, Therapeutics

Category(s): Technology Classifications > Cancer > Cancer Diagnostics, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Oncology, Technology Classifications > Medical > Therapeutics

A Smart-App, VR headset, Cloud and AI based Method to Detect Field of Vision Problems

Advantages: GlaucTest offers a cost-effective and accessible home test for the second leading cause of blindness worldwide The ease of testing and re-testing would increase the reliability and precision of tracking small changes that are otherwise difficult to capture Improved testing conditions will facilitate consistency and replicability Summary: Glaucoma,...

Published: 3/19/2025 | Inventor(s): Ramesh Ayyala, Sriram Chellappan, John Musser, Ahsan Wahab

Keywords(s): Diagnostics, Ophthalmic Equipment, Ophthalmology

Category(s): zzDiagnostics, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Medical Imaging, Technology Classifications > Medical > Ophthalmology

Early Screening Method for Fetal Growth Restriction (FGR)

Advantages: Earlier diagnosis than traditional FGR screening: can detect risk as early as the 1st or 2nd trimester Non-invasive testing with maternal blood Superior sensitivity and specificity compared to ultrasound-based detection Can be potentially further developed into a commercial product/ standard prenatal screening test for DNA methylation...

Published: 3/4/2025 | Inventor(s): Umit Kayisli, Anthony Odibo, Charles Lockwood, Ozlem Guzeloglu-Kayisli

Keywords(s): Women’s Health

Category(s): Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Womens Health

Novel Anti- Aggregation Therapeutic Targets Against Cystic Fibrosis Caused by Pseudomonas Aeruginosa

Advantages: Therapeutic Targets: Identified essential genes in Pa aggregate formation that can be potentially targeted with therapeutics Improved Infection Model: use of synthetic CF sputum media that closely mimics the physical and nutritional environment of CF sputum Potential for Broader Applications: can be extended to other bacterial species...

Published: 2/21/2025 | Inventor(s): Sophie Darch

Keywords(s): Medical Devices, Medical Diagnostics, Therapeutics

Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Medical Diagnostics

Antibacterial-Modified Comet Assay for the Study of Genome Integrity in Bacterial Pathogenesis

Advantages: The modified comet assay delivers consistent, reproducible results, ensuring reliable data for bacterial pathogenesis and DNA damage/repair studies A cost-effective and user-friendly antimicrobial peptide, making the modified comet assay an economical solution The method is versatile, applicable to bacteria, mammalian cells, microbiome,...

Published: 1/14/2025 | Inventor(s): Marcus Cooke, Haley Lockhart

Keywords(s):

Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Medical Diagnostics

New Target for Heart Failure Therapies: Modifying MRPS5/ATF4 Signaling in Cardiomyocytes

Advantages: Identification of MRPS5 as a Therapeutic Target: Reduction of MRPS5 expression stimulates cardiomyocyte proliferation and enhances heart function Discovery of the MRPS5 signaling axis: Decreased MRPS5 enhances ATF4 and Knl1, which promote cardiomyocyte, boosting cardiac recovery after myocardial injury Improved Survival and Cardiac...

Published: 1/17/2025 | Inventor(s): Da-Zhi Wang, John Mably

Keywords(s): Biotechnology, Cardiological Diseases Treatment, Cell & Tissue Culture & Engineering, Medical Diagnostics, Pharmaceuticals

Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications > Medical > Pharmaceuticals

Sensitive and Robust Biosensing Using Plasmonic Enhancement of Fluorescence by Rapid Thermal Annealed Silver Nanostructures

Advantages: Enhances cancer biomarker sensitivity Scalable production methods Enables low-concentration detection Ideal for portable diagnostics Summary: In cancer diagnostics, a major challenge is the detection of biomarkers at extremely low concentrations, particularly at the nanogram per milliliter (ng/ml) level, which is crucial for...

Published: 9/17/2024 | Inventor(s): Shuangming Li, Venkat Bhethanabotla

Keywords(s): Biomarker, Cancer Diagnostics

Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Electronics > Nanotechnology, Technology Classifications > Cancer > Cancer Diagnostics, Technology Classifications > Medical > Medical Nanotechnology, Technology Classifications > Medical > Medical Diagnostics

Cancer Patients with an Anti-Epstein-Barr Virus (EBV) Immune Response Show Improved Outcomes

Advantages: Cancers with an adaptive immune response (T cell and antibody response) to EBV correlate with better outcomes: tested in ovarian cancer, stomach adenocarcinoma, Burkitt lymphoma, and diffused large B cell lymphoma Could be developed into a potential predictive biomarker that utilizes antibody and/or T cell receptor CDR3 sequencing...

Published: 11/7/2024 | Inventor(s): George Blanck, Rahul Jain, Taha Huda, Srijit Paul, Boris Chobrutskiy, Andrea Chobrutskiy, Nandini Goel, Madeline Baker, Joanna Song, Veda Vangala, Michael Diaz

Keywords(s): Cancer Diagnostics

Category(s): Technology Classifications > Cancer > Cancer Diagnostics, Technology Classifications > Medical > Medical Diagnostics

3D Printed Swab for Diagnostic Testing

Advantages: 3D-printed swab comprising a shaft and a plurality of protrusions, that can be manufactured at high capacity with low potential for contamination. 3D-printed swabs can be manufactured with various tip shapes and stem lengths to help optimize sample collections from different targeted locations. 3D printing allows tip diameters...

Published: 7/30/2024 | Inventor(s): Summer Decker, Jonathan Ford, Michael Teng, Kami Kim, Todd Hazelton, John Sinnott, Todd Goldstein

Keywords(s): Medical Devices, Medical Diagnostics

Category(s): Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Medical Devices

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