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Advantages: R/S 1,3-butanediol diacetoacetate clinically demonstrated superior weight loss compared to standard rodent chow or ketogenic diet Long-lasting weight maintenance suggests metabolic adaptations compared to typical diet-based approaches Scalable and cost-effective single-agent solution, offering a financial advantage over existing options Summary: Achieving...

Published: 2/26/2025 | Inventor(s): Dominic D'Agostino, Angela Poff, Andrew Koutnik

Keywords(s): Nutrition / Diet Health

Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Chemistry

Antimicrobial Terpenes From a Deep-Sea Irish Coral

Advantages: A novel structural diversity (anthoteibinenes A-Q) offers bioactive scaffolds, absent in standard combinatorial chemistry libraries Anthoteibinenes I and J have demonstrated activity against multiple Candida strains, indicating possible antibacterial efficacy Selective bioassay- and NMR-guided isolation provides a more targeted approach...

Published: 2/21/2025 | Inventor(s): Bill Baker, Stine Olsen, Mark Johnson, Louise Allcock, Sam Afoullouss, Ezequiel Rosa, Ryan Young

Keywords(s):

Category(s): Technology Classifications > Chemistry, Technology Classifications > Medical, Technology Classifications > Medical > Pharmaceuticals

Prevention of Abnormal Uterine Bleeding Caused by Progestin-Only Long-Acting Reversible Contraceptives

Advantages: 15dPGJ2 blocks the proliferation of human endometrial endothelial cells, thereby preventing pLARC-induced aberrant endometrial angiogenesis, a major cause of unexpected uterine bleeding 15dPGJ2 enhances progestin responsiveness and prevents pLARC-induced inflammation, another contributor to uterine vascular instability, effectively reducing...

Published: 2/19/2025 | Inventor(s): Charles Lockwood, Ozlem Guzeloglu-Kayisli, Umit Kayisli

Keywords(s): Women’s Health

Category(s): Technology Classifications > Medical, Technology Classifications > Chemistry, Technology Classifications > Medical > Pharmaceuticals

Colorectal Cancer Gene Expression Signature as a Predictor for Therapy Outcomes

Advantages: Novel biomarker development: Unique 10-gene signatures distinguish the contributions of tumor epithelium (EPI) & tumor microenvironment (TME) in colorectal cancer (CRC) Clinical Relevance: EPIS signature predicts better progression-free survival in cetuximab-treated metastatic CRC patients; TMES correlates with worse survival outcomes Enhanced...

Published: 2/12/2025 | Inventor(s): Timothy Yeatman, Mingli Yang

Keywords(s): Cancer Treatment, Pharmaceuticals

Category(s): Technology Classifications > Cancer, Technology Classifications > Medical, Technology Classifications > Chemistry

Ciproloxacin-Based Polyacrylate nanoparticle Emulsions for Antibiotic Applications

Advantages: A water-soluble nanoparticle emulsion with an antibiotic monomer foundation has the ability to fight antibiotic-resistant bacterial infections The emulsion technique facilitates the conversion of antibiotics into nanoparticles that are protected from degradative enzymes The aqueous homo-polymer nanoparticle offers stability, versatility,...

Published: 2/3/2025 | Inventor(s): Edward Turos, Faeez Mahzamani

Keywords(s): Drug Delivery and Nanomedicine, Drug Delivery Systems

Category(s): Technology Classifications > Chemistry, Technology Classifications > Chemistry > Polymers, Technology Classifications > Medical > Medical Nanotechnology, Technology Classifications > Medical > Therapeutics

Antiviral Properties of Deep-Sea Coral Metabolites

Advantages: A novel compound for developing new antiviral drugs extracted from the Irish deep-sea soft coral Anthoteibinene B exhibits significant antiviral activity against Respiratory Syncytial Virus (RSV) without cytotoxic effects N,N-dimethylaminoethyl substituents further enhance antiviral properties by improving solubility, bioavailability,...

Published: 11/7/2024 | Inventor(s): Bill Baker, Stine Olsen, Sam Afoullouss, Kim Teng, Michael Teng, Louise Allcock, Mark Johnson

Keywords(s): Antiviral Therapeutics

Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Chemistry, Technology Classifications > Medical > Therapeutics

NOVEL SMALL MOLECULE NEGATIVE ALLOSTERIC MODULATORS OF THE MU-OPIOD RECEPTOR

NOVEL SMALL MOLECULE NEGATIVE ALLOSTERIC MODULATORS OF THE MU-OPIOD RECEPTOR Researchers at Stanford University and Washington University have discovered a novel molecular pathway for the treatment of opioid overdose. Opioids are a powerful tool for pain management when used in clinical care settings. However, in recent years these drugs have...

Published: 9/24/2024 | Inventor(s): Evan Obrien, Kaavya Kumar, Brian Kobilka, Susruta Majumdar, Vipin Rangari

Keywords(s): Opiod, Pain

Category(s): Technology Classifications > Chemistry

Photodegradation Protection of Polymeric Materials by Encapsulating with Inorganic Composites and Applications Thereof

Advantages: Boosts the average lifespan of polymers preventing them from undergoing UV-induced photodegradation. Decreases the frequency of replacements and repair process, which translates into tremendous cost savings. Summary: Various fields employ polymeric and organic materials which are prone to photodegradation under UV radiation...

Published: 7/9/2024 | Inventor(s): Elias Stefanakos, Sesha Srinivasan

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Category(s): Technology Classifications > Electronics > Electronics Laser, Technology Classifications > Advance Materials, Technology Classifications > Chemistry, Technology Classifications > Electronics > Nanotechnology, Technology Classifications > Engineering > Electrical Engineering

Intermetallic Fe Based Catalysts for Light Olefin Production

Advantages: High Selectivity: Up to 45% light olefin selectivity with CO2 included. Exceptional Stability: Maintains performance over a 72-hour run. Customizable Reactivity: Fe:In ratios tune surface composition for optimized olefin production and reduced by-products. Summary: This technology addresses a critical need in the chemical industry...

Published: 8/22/2024 | Inventor(s): John Kuhn, Babu Joseph, Yang He

Keywords(s): Chemistry and Chemical Engineering, Material Science

Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Chemistry, Technology Classifications > Energy & Environment > Energy Engineering

Dye and Polyphenol Modified Carbon Quantum Dots (CQ-dots) with Tunable Fluorescent, Antipathogenic, Antioxidant and Anticancer Properties

Advantages: Enhanced optical properties enable superior bioimaging and precise detection in medical diagnostics and research. Multifunctional antipathogenic properties make the modified CQ-dots effective against a wide range of microorganisms, addressing healthcare demands for antimicrobial materials. Versatile applications across industries,...

Published: 6/27/2024 | Inventor(s): NURETTIN SAHINER, Ramesh Ayyala

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Category(s): Technology Classifications, Technology Classifications > Electronics > Nanotechnology, Technology Classifications > Chemistry, Technology Classifications > Medical > Biomaterials

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