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A High-Throughput NMR Method for In-Membrane Ligand-Screening
Advantages: Maintains the original structural and functional properties of receptor proteins Enables high-throughput screening through automated NMR workflows with minimal sample quantities Enhanced Signal-to-Noise Ratio improves detection of ligand-receptor interactions (e.g. binding orientations, kinetics, and dynamics) Applicable to any membrane...
Published: 4/30/2025   |   Inventor(s): Libin Ye, Xudong Wang
Keywords(s): Drug Delivery and Nanomedicine, Drug Discovery
Category(s): Technology Classifications, Technology Classifications > Chemistry, Technology Classifications > Medical > Biotechnology
Novel Combination Treatment for Glioblastoma
Advantages: Temozolomide (TMZ), Cannabidiol (CBD), and CCR6/CCL20 inhibitors work together to overcome Glioblastoma resistance and enhance efficacy Targeted CCL20/CCR6 inhibition blocks survival pathways in glioblastoma, reducing resistance and relapse while improving outcomes Enhances CD8+ T cells and rewires immunity, offering powerful, lasting...
Published: 4/30/2025   |   Inventor(s): Subhra Mohapatra, Shyam Mohapatra, Ryan Green, Karthick Mayilsamy
Keywords(s): Cancer Treatment, Pharmaceuticals
Category(s): Technology Classifications > Chemistry, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical
Novel Potential Glaucoma Therapy via Secretome Treatment of Schlemm’s Canal Endothelial Cells
Advantages: Minimally invasive secretome therapy enhances Schlemm’s canal function, offering a non-surgical alternative to glaucoma treatment Secretome therapy promotes cellular repair and wound healing, addressing TM damage beyond Increased Intraocular Pressure (IOP) reduction Secretome therapy enhances aqueous outflow by upregulating tight...
Published: 4/17/2025   |   Inventor(s): Rong Du, Yiqin Du, Enzhi Yang
Keywords(s): Ophthalmology
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical, Technology Classifications > Chemistry
Ketone for Weight Loss Maintenance
Advantages: R/S 1,3-butanediol diacetoacetate clinically demonstrated superior weight loss compared to standard rodent chow or ketogenic diet Long-lasting weight maintenance suggests metabolic adaptations compared to typical diet-based approaches Scalable and cost-effective single-agent solution, offering a financial advantage over existing options Summary: Achieving...
Published: 2/26/2025   |   Inventor(s): Dominic D'Agostino, Angela Poff, Andrew Koutnik
Keywords(s): Nutrition / Diet Health
Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Chemistry
Antimicrobial Terpenes From a Deep-Sea Irish Coral
Advantages: A novel structural diversity (anthoteibinenes A-Q) offers bioactive scaffolds, absent in standard combinatorial chemistry libraries Anthoteibinenes I and J have demonstrated activity against multiple Candida strains, indicating possible antibacterial efficacy Selective bioassay- and NMR-guided isolation provides a more targeted approach...
Published: 2/21/2025   |   Inventor(s): Bill Baker, Stine Olsen, Mark Johnson, Louise Allcock, Sam Afoullouss, Ezequiel Rosa, Ryan Young
Keywords(s):  
Category(s): Technology Classifications > Chemistry, Technology Classifications > Medical, Technology Classifications > Medical > Pharmaceuticals
Prevention of Abnormal Uterine Bleeding Caused by Progestin-Only Long-Acting Reversible Contraceptives
Advantages: 15dPGJ2 blocks the proliferation of human endometrial endothelial cells, thereby preventing pLARC-induced aberrant endometrial angiogenesis, a major cause of unexpected uterine bleeding 15dPGJ2 enhances progestin responsiveness and prevents pLARC-induced inflammation, another contributor to uterine vascular instability, effectively reducing...
Published: 2/19/2025   |   Inventor(s): Charles Lockwood, Ozlem Guzeloglu-Kayisli, Umit Kayisli
Keywords(s): Women’s Health
Category(s): Technology Classifications > Medical, Technology Classifications > Chemistry, Technology Classifications > Medical > Pharmaceuticals
Colorectal Cancer Gene Expression Signature as a Predictor for Therapy Outcomes
Advantages: Novel biomarker development: Unique 10-gene signatures distinguish the contributions of tumor epithelium (EPI) & tumor microenvironment (TME) in colorectal cancer (CRC) Clinical Relevance: EPIS signature predicts better progression-free survival in cetuximab-treated metastatic CRC patients; TMES correlates with worse survival outcomes Enhanced...
Published: 2/12/2025   |   Inventor(s): Timothy Yeatman, Mingli Yang
Keywords(s): Cancer Treatment, Pharmaceuticals
Category(s): Technology Classifications > Cancer, Technology Classifications > Medical, Technology Classifications > Chemistry
Ciproloxacin-Based Polyacrylate nanoparticle Emulsions for Antibiotic Applications
Advantages: A water-soluble nanoparticle emulsion with an antibiotic monomer foundation has the ability to fight antibiotic-resistant bacterial infections The emulsion technique facilitates the conversion of antibiotics into nanoparticles that are protected from degradative enzymes The aqueous homo-polymer nanoparticle offers stability, versatility,...
Published: 2/3/2025   |   Inventor(s): Edward Turos, Faeez Mahzamani
Keywords(s): Drug Delivery and Nanomedicine, Drug Delivery Systems
Category(s): Technology Classifications > Chemistry, Technology Classifications > Chemistry > Polymers, Technology Classifications > Medical > Medical Nanotechnology, Technology Classifications > Medical > Therapeutics
Antiviral Properties of Deep-Sea Coral Metabolites
Advantages: A novel compound for developing new antiviral drugs extracted from the Irish deep-sea soft coral Anthoteibinene B exhibits significant antiviral activity against Respiratory Syncytial Virus (RSV) without cytotoxic effects N,N-dimethylaminoethyl substituents further enhance antiviral properties by improving solubility, bioavailability,...
Published: 4/16/2025   |   Inventor(s): Bill Baker, Stine Olsen, Sam Afoullouss, Kim Teng, Michael Teng, Louise Allcock, Mark Johnson
Keywords(s): Antiviral Therapeutics
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Chemistry, Technology Classifications > Medical > Therapeutics
­NOVEL SMALL MOLECULE NEGATIVE ALLOSTERIC MODULATORS OF THE MU-OPIOD RECEPTOR
­NOVEL SMALL MOLECULE NEGATIVE ALLOSTERIC MODULATORS OF THE MU-OPIOD RECEPTOR Researchers at Stanford University and Washington University have discovered a novel molecular pathway for the treatment of opioid overdose. Opioids are a powerful tool for pain management when used in clinical care settings. However, in recent years these drugs have...
Published: 9/24/2024   |   Inventor(s): Evan Obrien, Kaavya Kumar, Brian Kobilka, Susruta Majumdar, Vipin Rangari
Keywords(s): Opiod, Pain
Category(s): Technology Classifications > Chemistry
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