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Phosphonium Metal Halide Semiconductors for PFAS Detection
Advantages Exceptional water stability, with demonstrated structural integrity for over 22 months in aqueous environments Improved thermal stability by up to 160 °C higher than conventional ammonium-based analogues Tunable optical and electrochemical properties suitable for sensing, optoelectronics, and energy applications Enables low-cost,...
Published: 3/4/2026   |   Inventor(s): Ioannis Spanopoulos, Ali Azmy, Zois Syrgiannis, Anand Tiwari
Keywords(s): Chemistry and Chemical Engineering, Environmental Sciences, Nanotechnology
Category(s): Technology Classifications > Advance Materials, Technology Classifications > Chemistry, Technology Classifications > Electronics > Nanotechnology, Technology Classifications > Energy & Environment, Technology Classifications > Electronics > Electronics Sensors
ICA‑1S and ζ‑Stat: Selective aPKC Inhibitors for Anti‑Angiogenic Control Neuroblastoma
Advantages Upstream pathway control: Suppresses VEGF‑A by targeting aPKC, a master regulator of angiogenic signaling. Selective, small-molecule mechanism: offers lower immunogenicity and easier development than antibody-based therapies. Combination-therapy ready: upstream angiogenic pathway control enables synergy with existing treatments. Summary Neuroblastoma...
Published: 3/6/2026   |   Inventor(s): Sloan Breedy, Wishrawana Ratnayake, Mildred Acevedo-Duncan
Keywords(s): Cancer Treatment, Small Molecules
Category(s): Technology Classifications > Cancer, Technology Classifications > Chemistry, Technology Classifications > Medical > Oncology, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals
Novel Therapy to Prevent Kidney Transplant Rejection
Advantages First-in-class mechanism: Only known PPP1R3G/PP1γ inhibitor—differentiated from all RIPK1/RIPK3 competitors Upstream targeting: Acts before RIPK1 activation for potentially improved selectivity Validated efficacy: Demonstrated reduction in necroptosis markers (p-RIP1, p-RIP3, p-MLKL) Large unmet need: No approved DGF prevention...
Published: 2/11/2026   |   Inventor(s): Lei Wang, Zhigao Wang, Jianfeng Cai
Keywords(s): Organ Transplantation, Renal / Kidney
Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Chemistry, Technology Classifications > Medical > Therapeutics
Exogenous Acetate Formulations for Treating Alcohol Use Disorder and Withdrawal
Advantages Mechanistic Innovation: stabilizes brain energy metabolism and modulates adenosine signaling mechanisms not targeted by current addiction therapies. Targeted Brain Delivery: formulations enable effective acetate transport across the blood-brain barrier, (BBB) Controlled and sustained release Versatile Administration Routes: compatible...
Published: 9/30/2025   |   Inventor(s): Dominic D'Agostino
Keywords(s): Neuroscience, Pharmaceuticals
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Therapeutics, Technology Classifications > Chemistry, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Neuroscience
A Breakthrough for Corneal Regeneration: Bioengineered Membrane Immerged with Stem Cell Secretome/Extracellular Vesicles
Advantages Donor-Free Alternative: Eliminates the need for donor corneas in treating shallow corneal opacity, utilizes secretomes and/or extracellular vesicles from stem cells to promote natural healing and tissue regeneration Enhanced Healing Performance: Improves wound closure and reduce fibrosis Sustained and controlled Therapeutic Release ...
Published: 11/7/2025   |   Inventor(s): Rohit Sharma, Yiqin Du
Keywords(s): Ophthalmology
Category(s): Technology Classifications > Chemistry, Technology Classifications > Chemistry > Polymers, Technology Classifications > Medical, Technology Classifications > Medical > Biomaterials, Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications > Medical > Ophthalmology
Novel Heart Failure Therapy: Farnesyltransferase Inhibition Targets Protein Aggregation in Cardiomyocytes
Advantages First-in-Class Mechanism: Targets a novel pathway—protein farnesylation—for heart failure treatment. Broad Therapeutic Potential: Effective in both HFrEF and HFpEF, addressing a major unmet need. Tested in multiple preclinical models: Danon disease cardiomyopathy (genetic model); HFpEF (diet-induced and hypertensive models);...
Published: 11/7/2025   |   Inventor(s): Kunhua Song, Congwu Chi, Amanda Conniff
Keywords(s): Cardiovascular Diseases, Drug Repurpose, Medical Pharmaceuticals, Therapeutics
Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Biotechnology, Technology Classifications > Chemistry
Photocatalytic C-C Coupling of Terminal Alkynes using CuO Mie Resonators
Advantages Solar-driven visible-light catalysis eliminates high-temperature fossil fuel dependence Rapid phenylacetylene conversion yields 100% within 45 minutes (CuO–Pd) Employs earth-abundant copper oxide reducing overall catalyst costs Scalable heterogeneous system offers high selectivity, facile recyclability Summary Traditional carbon–carbon...
Published: 8/26/2025   |   Inventor(s): Shivam Kumar, Dharendra Goswami, Marimmuthu Andiappan
Keywords(s): Chemistry and Chemical Engineering
Category(s): Technology Classifications > Advance Materials, Technology Classifications > Electronics > Nanotechnology, Technology Classifications > Chemistry
A High-Throughput NMR Method for In-Membrane Ligand-Screening
Advantages: Maintains the original structural and functional properties of receptor proteins Enables high-throughput screening through automated NMR workflows with minimal sample quantities Enhanced Signal-to-Noise Ratio improves detection of ligand-receptor interactions (e.g. binding orientations, kinetics, and dynamics) Applicable to any membrane...
Published: 4/30/2025   |   Inventor(s): Libin Ye, Xudong Wang
Keywords(s): Drug Delivery and Nanomedicine, Drug Discovery
Category(s): Technology Classifications, Technology Classifications > Chemistry, Technology Classifications > Medical > Biotechnology
Novel Combination Treatment for Glioblastoma
Advantages: Temozolomide (TMZ), Cannabidiol (CBD), and CCR6/CCL20 inhibitors work together to overcome Glioblastoma resistance and enhance efficacy Targeted CCL20/CCR6 inhibition blocks survival pathways in glioblastoma, reducing resistance and relapse while improving outcomes Enhances CD8+ T cells and rewires immunity, offering powerful, lasting...
Published: 2/16/2026   |   Inventor(s): Subhra Mohapatra, Shyam Mohapatra, Ryan Green, Karthick Mayilsamy
Keywords(s): Cancer Treatment, Pharmaceuticals
Category(s): Technology Classifications > Chemistry, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical
Novel Potential Glaucoma Therapy via Secretome Treatment of Schlemm’s Canal Endothelial Cells
Advantages: Minimally invasive secretome therapy enhances Schlemm’s canal function, offering a non-surgical alternative to glaucoma treatment Secretome therapy promotes cellular repair and wound healing, addressing TM damage beyond Increased Intraocular Pressure (IOP) reduction Secretome therapy enhances aqueous outflow by upregulating tight...
Published: 10/14/2025   |   Inventor(s): Rong Du, Yiqin Du, Enzhi Yang
Keywords(s): Ophthalmology
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical, Technology Classifications > Chemistry
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