Search Results - taoyuanmin+zhu

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Novel Human Insulin Cα-Peptide as an Antagonist for Islet and Brain Amyloidosis

Abstract: Over 32 million Americans are living with Diabetes and newly diagnosed cases of type 1 and type 2 diabetes is increasing. A defining feature of type 2 diabetes mellitus (T2DM) is the accumulation of islet amyloid polypeptide (IAPP) fibrils in pancreatic islets. Such accumulations form amyloid plaques, referred to as islet amyloidosis. Mounting...

Published: 4/8/2024 | Inventor(s): Qing Rong Liu, Min Zhu, Pingbo Zhang, Josephine Egan, Luigi Ferrucci

Keywords(s): Alzheimer’s Disease, Amyloidosis, C-peptide, DIABETES, Egan, insulin, Islet Amyloid Polypeptide, Liu, National Institute on Aging, NIA

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Endocrinology

Novel Human Islet Amyloid Polypeptides as Alzheimer’s Disease Biomarkers and Inhibitors of Amyloid Formation

Abstract: Over 34 million Americans are living with diabetes. An estimated 6.5 million Americans are living with Alzheimer’s disease (AD) and type 2 diabetes mellites (T2DM). Amyloidosis due to aggregation of amyloid-β is key pathogenic event in AD, whereas aggregation of mature islet amyloid polypeptide (IAPP37) in human islet leads to β-cell dysfunction....

Published: 5/23/2024 | Inventor(s): Qing Rong Liu, Min Zhu, Josephine Egan

Keywords(s): Ad, Age-Associated Disease, Alzheimer’s Disease, Amyloidosis, Amyloids, Biomarkers, DIABETES, IAPP, Islet Amyloid Polypeptide Isoforms, Liu, National Institute on Aging, NIA, PEPTIDYL

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics

Latching Intelligent Modular Mobility System (LIMMS) (UCLA Case Nos. 2023-170 and 2023-171)

Summary: UCLA researchers in the Department of Mechanical and Aerospace Engineering have designed a modular robotic system termed the Latching Intelligent Modular Mobility System (LIMMS) for the manipulation of a typical last-mile delivery. TITLE: Latching Intelligent Modular Mobility System (LIMMS) for Logistics and Last-Mile Delivery Background: The...

Published: 9/17/2024 | Inventor(s): Dennis Hong, Taoyuanmin Zhu, Gabriel Fernandez

Keywords(s): 6 degrees of freedom (DoF), Amazon, appendage-like robot, automated delivery, delivery optimization, delivery system, general purpose delivery, last-mile delivery, latching mechanism, modular robotic system, rotational latching mechanism, self-aligning rotational mechanism

Category(s): Mechanical, Mechanical > Robotics, Mechanical > Mechanical Systems, Mechanical > Manufacturing

Curing Hepatitis B Infections Using a Therapy that Suppresses HBV Replication

Published: 6/14/2021 | Inventor(s): John Tavis, Yuan Hu

Keywords(s):

Category(s): Therapeutics

Water-based, highly tunable and biocompatible silk-based bioink

SUMMARYTufts investigators have developed biopolymer-based ink formulations that are useful for inkjet printing and other applications.PROBLEMPreparation of water-based, highly-tunable and biocompatible bioinks remains a challenge. It often requires complicated multistep manufacturing process that is time-consuming, energy-intensive and...

Published: 9/30/2020 | Inventor(s): Fiorenzo Omenetto, David Kaplan, Hu Tao, Benedetto Marelli, Miaomiao Yang

Keywords(s):

Category(s): Biomaterials

Electronic components on paper-based substrates

Electronic components on paper-based substratesThe present disclosure relates to paper-based substrates and apparatus comprising such substrates. The apparatus may include a patterned conductive structure coupled to the paper-based substrate, wherein the patterned conductive structure responds to electromagnetic radiation. Since paper-based substrates...

Published: 9/10/2020 | Inventor(s): Fiorenzo Omenetto, David Kaplan, Hu Tao

Keywords(s):

Category(s): Diagnostic

A System For Visual Presentation Of Concepts From Ontology And Text Documents

PAGE TITLEOverviewPAGE SUMMARYA system lets a user click on a location of a brain model to explore neuroscience ontology terms related to the location. The user can further explore the related terms and related documents through a visualization interface and learn new concept or document relationships derived from the ontology and annotated document...

Published: 7/24/2024 | Inventor(s): Yuan An, Xia Lin, Mi Zhang, Yue Shang

Keywords(s):

Category(s): Computing, Software, Analytics & Information Technology, Computing, Software, Analytics & Information Technology > Computing: Algorithms, Computing, Software, Analytics & Information Technology > Computing: Contextual Analytics, Computing, Software, Analytics & Information Technology > Computing: Data Mining, Computing, Software, Analytics & Information Technology > Computing: Databases

Silk Water Lithography

SUMMARYTufts University investigators have developed a room temperature lithography technique that eliminates the need for expensive equipment and minimizes the use of harsh chemicals without sacrificing resolution.DESCRIPTION A resist film that is composed of a biocompatible and biodegradable polymer (derived from silk) combined with a water-based...

Published: 9/30/2020 | Inventor(s): Fiorenzo Omenetto, David Kaplan, Miaomiao Yang, Hu Tao, Benedetto Marelli, Sunghwan Kim

Keywords(s):

Category(s): Materials

Chance-Constrained Optimization for Treatment of Prostate and Other Cancers in Intensity-Modulated Proton Therapy

The quality of IMPT treatment plans may be drastically diminished by uncertainties such as proton range and patient setup errors. If these uncertainties are not figured into treatment planning, the dose distribution that the patient receives may not be the same as the planned dose distribution. New treatment plans, which include optimized software/programming,...

Published: 4/19/2023 | Inventor(s): Jianming Liang, Yu An, Wei Liu

Keywords(s):

Category(s): Computing & Information Technology, Life Science (All LS Techs), Medical Imaging

Gold Nanoparticle-Doped Biocompatible Silk Films as a Path to Implantable Thermal-electrically Wireless Powering Devices

Tufts researchers have developed silk-based photothermal devices capable of wirelessly converting light energy into heat. These devices are mechanically robust, implantable, biocompatible and biodegradable, which makes them useful for a wide range of in vivo applications including photothermal therapy, controlled drug delivery, wireless powering of...

Published: 6/4/2020 | Inventor(s): Fiorenzo Omenetto, Hu Tao, David Kaplan

Keywords(s):

Category(s): Energy, Materials: polymers, Optics, Medical devices, Therapeutic

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