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Search Results - shiqi+zhang
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COMBINATION THERAPIES FOR COVID-19 (SARS-COV-2)
The coronavirus disease 2019 (COVID-19) is caused by a novel RNA enveloped coronavirus, SARS-CoV-2 when the virus enters human airway cells via an ACE2-mediated entry process. This entry pathway is facilitated by the cell surface heparan sulfate proteoglycan (HSPG), which enhances viral attachment to the cell surface. Researchers at NIDDK and NCATS...
Published: 7/25/2024
|
Inventor(s):
Qi Zhang
,
Wei Zheng
,
Catherine Chen
,
Yihong Ye
Keywords(s):
COVID-19
,
DB4BXX
,
ENTRY
,
HEPARAN
,
option
,
Sulfate-dependent
,
Targeting
,
therapeutic
,
viral
Category(s):
Collaboration Sought > Collaboration
,
TherapeuticArea > Infectious Disease
,
Application > Therapeutics
A method to label heparan sulfate proteoglycan in the plasma membrane of mammalian cells
Heparan sulfate proteoglycan (HSPG) is a group of lipid-anchored proteoglycans, engaged in a variety of key biological functions on cell surface. HSPG-mediated endocytosis of neurotoxic protein aggregates has been linked to aging related neurodegenerative diseases. Labeling HSPG is a promising technique to trace cell profile in cell research, monitor...
Published: 7/25/2024
|
Inventor(s):
Qi Zhang
,
Yihong Ye
Keywords(s):
Cells
,
HEPARAN
,
Label
,
MAMMALIAN
,
MEMBRANE
,
Method
,
PLASMA
,
PROTEOGLYCAN
,
R1XXXX
,
SULFATE
,
XCXXXX
Category(s):
Collaboration Sought > Collaboration
,
Application > Diagnostics
,
Application > Research Materials
Method for 3D Nonlinear Structured Illumination Super-resolution Imaging
Researchers at the University of Arizona have developed a super-resolution microscopy method that is faster, easier to use, and has less artifacts than current super-resolution methods. The result is a 3D dual-color stimulated emission depletion (STED) nonlinear structured illumination (NL-SIM) microscope. Using a combination of low coherent light and...
Published: 4/3/2023
|
Inventor(s):
Leilei Peng
,
Yu Li
,
Han Zhang
Keywords(s):
Category(s):
Technology Classifications > Imaging & Optics
,
Technology Classifications > Imaging & Optics > Medical Imaging
,
Technology Classifications > Imaging & Optics > Microscopy, Spectroscopy, Polarimetry
A Mutually Inhibitory Network with Positive Autoregulation and Communications (MINPAC)
Biological pattern formation requires complex gene regulation networks and accurate cell-cell coordination. The reaction-diffusion (RD) based clock and wavefront model has been proposed as a mechanism involved in biological pattern formation of repeated and segmented structures. While RD driven pattern formation has been demonstrated in many systems,...
Published: 2/23/2023
|
Inventor(s):
Fuqing Wu
,
Samat Bayakhmetov
,
Changhan He
,
Qi Zhang
,
Xingwen Chen
,
Yang Kuang
,
Xiao Wang
Keywords(s):
Category(s):
Genomic Assays/Reagents/Tools
,
Life Science (All LS Techs)
,
Computing & Information Technology
Pathogen Molecular Detection Platform
Accurate detection and diagnosis of infectious diseases is paramount to appropriate treatment and better outcomes. Despite tremendous efforts to advance new diagnostic techniques, there are still critical gaps in the healthcare system in quickly diagnosing and responding to infectious diseases. Current diagnostic technologies identify pathogens by detecting...
Published: 2/23/2023
|
Inventor(s):
Qi Zhang
,
Xiao Wang
,
Alexander Green
,
Duo Ma
,
Fuqing Wu
,
Kylie Standage-Beier
,
Xingwen Chen
Keywords(s):
Category(s):
Advanced Materials/Nanotechnology
,
Applied Technologies
,
Bioanalytical Assays, Chemistries & Devices
,
Diagnostic Assays/Devices
,
Life Science (All LS Techs)
,
Genomic Assays/Reagents/Tools
,
Proteomic Assays/Reagents/Tools
,
Medical Diagnostics/Sensors
Negotiation-based Human-Robot Collaboration via Augmented Reality
An augmented reality-driven, negotiation-based framework for human-robot collaboration Background: There are a variety of robot platforms that have been developed for very different purposes. Some examples include: warehouse robots, indoor service robots, military robots, and rescue robots. Despite their capabilities of accomplishing complex tasks...
Published: 12/28/2023
|
Inventor(s):
Shiqi Zhang
,
Kishan Chandan
Keywords(s):
Category(s):
Campus > Binghamton University
,
Technology Classifications > Artificial Intelligence
Model for Gene Expression Tuning and Synthetic Gene Circuit Construction
Genetic circuit engineering has played an important role in many forms of synthetic biology. Based on a large collection of well characterized biological components, complex gene circuits with designed functions can be wired using established biological principles. Currently circuit assembly has two main strategies: one is monocistronic construct, in...
Published: 2/23/2023
|
Inventor(s):
Fuqing Wu
,
Xiao Wang
,
Qi Zhang
Keywords(s):
Category(s):
Computing & Information Technology
,
Genomic Assays/Reagents/Tools
,
Proteomic Assays/Reagents/Tools
,
Life Science (All LS Techs)
PI3Kα Inhibitors for the Treatment of Cancer
Application Compounds that inhibit the kinase activity of phospoinostidie 3-kinase (PI3Kα) for the treatment of cancer. Key Benefits Potential therapeutic targeted to pathway without a clinically approved inhibitor. Provides a useful pharmacological probe for research purposes. Market Summary In order to grow, cancer cells must have the...
Published: 7/30/2024
|
Inventor(s):
Qi Shi
,
Thomas Kaiser
,
Dennis Liotta
,
James Snyder
,
Zackery Dentmon
,
John Diraddo
Keywords(s):
Oncology
,
Small Molecule
Category(s):
TechPub Algolia > Therapeutics
Derivatives as CXCR4 Modulators for the Treatment of Inflammation and Metastasis
Application Amide derivatives as chemokine receptor type 4 (CXCR4) modulators for the treatment of inflammation or prevention of cancer cell metastasis. Key Benefits Excellent binding affinity, compared to currently available compounds targeting CXCR4 receptor. Stability in plasma compared to protein/peptide agonists of CXCR4, these amide derivatives...
Published: 7/30/2024
|
Inventor(s):
Hyunsuk Shim
,
Renren Bai
,
Qi Shi
Keywords(s):
Immunology/Inflammation
,
Oncology
,
Small Molecule
Category(s):
TechPub Algolia > Therapeutics