Search Results - mingsheng+chen

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Identification and Use of Heterocyclic Alcohol Compounds for the Treatment of SULT1A1-expressing Cancers
This technology includes the identification and use of heterocyclic alcohol compounds, including RITA and N-BIC, for the treatment of SULT1A1-expression cancers. A high-throughput screen (qHTS) was performed using >1,000 caner cell lines identified a compound called YC-1 (also called Lificiguat) that is effective across cancer cell types that express...
Published: 10/28/2024   |   Inventor(s): Min Shen, Ke Kong, Toble Lee, Samarjit Patnaik, Olivia Lee, Jonathan Shrimp, Mindy Davis, Juan Marugan, Wei Zhao, Matthew Hall
Keywords(s): Agents, Alcohol, anti-cancer, Class, compounds, HETEROCYCLIC, SULT1A1-dependent, VCXXXX, WKXXXX, XCXXXX, XEXXXX
Category(s): Application > Research Materials, Application > Therapeutics, Application > Diagnostics, TherapeuticArea > Oncology
Pyruvate Kinase M2 Activators for the Treatment of Cancer
This technology describes a series of small-molecule activators of the pyruvate kinase M2 isoform (PK-M2). Pyruvate kinase (PK) is a critical metabolic enzyme that catalyzes the last step of the glycolytic pathway. It exists in several isoforms with different patterns of tissue expression. One isoform, PK-M2, is expressed in cells with a high rate...
Published: 11/5/2024   |   Inventor(s): Jian-kang Jiang, Matthew Boxer, Min Shen, Douglas Auld, Craig Thomas
Keywords(s): Activator, ACTIVATORS, CANCER, CBXXXX, CXXXXX, Dimer, IBXXXX, ISOFORM, IXXXXX, M2, METABOLIC, METABOLITE, PK, PKM2, PK-M2, Proliferation, PYRUVATE, pyruvate kinase, small molecule, Tetramer, tumor
Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Oncology, Application > Diagnostics, Application > Research Materials
Pyruvate Kinase M2 Activators for the Treatment of Cancer
NIH investigators have discovered a series of small compounds with the potential to treat a variety of cancers as well as hemolytic anemia. Contrary to most cancer medications, these molecules can be non-toxic to normal cells because they target a protein specific to the metabolic pathways in tumors, thus representing a significant clinical advantage...
Published: 10/28/2024   |   Inventor(s): Min Shen, Craig Thomas, Douglas Auld, Matthew Boxer
Keywords(s): [1, [b], 2, 2-oxo-1, 3, 3-oxo-3, 4], 4-dihydroquinoline-2H-benzo, 4-tetrahydroquinoline-6-sulfonamides, ACTIVATORS, CB3CXX, CB3XXX, CBXXXX, CXXXXX, Human, Kinase, MOLECULE, Oxazine-7-sulfonamides, Patent Category - Chemistry, PYRUVATE, Small, Substituted
Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Oncology
Nanopore Tweezer System for Protein Kinase Allosteric Drug Screening
­ PRODUCT OPPORTUNITIES AND END-USE APPLICATIONS • Nanopore-tweezer-based system for efficient kinase allosteric drug screening ADVANTAGES • Label-free method • Capable of identifying both allosteric inhibitors and activators • Capable of distinguishing active-site inhibitors from allosteric...
Published: 8/3/2023   |   Inventor(s): Min Chen, Fanjun Li
Keywords(s):  
Category(s): Biotechnology, Life Sciences, Research tools
Nanopore-based Sensors for Antibody Screening Applications
PRODUCT OPPORTUNITIES AND END-USE APPLICATIONS • Nanopore-based antibody screening system • Nanopore sensors for antibody detection and identification • Antibody screening in hybridoma-based antibody production • Real-time monitoring of antibody production in cell culture ADVANTAGES •...
Published: 6/26/2023   |   Inventor(s): Min Chen, Joshua Foster, Minji Kim, Matthew Moore
Keywords(s):  
Category(s): Devices & sensors, Life Sciences, Research tools
Novel Multi-Omics Aging Clock
­A multi-omics clock analyzes multiple layers of omics data with machine learning to predict remaining lifespan of mammals, particularly for animal model studies. Large omics data sets may be used from combinations of genomics, proteomics, lipids, etc. available from blood or other simple sample collection. This tool can robustly capture changes...
Published: 3/12/2024   |   Inventor(s): George Sutphin, Samuel Freitas, Megha Padi, Chen Chen
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Simulators and Modeling Tools
Autonomous Drone for railroad track inspection
Reference #: 01564 The University of South Carolina is offering licensing opportunities for Autonomous Drone for railroad track inspection Background: The current practices suffer from three main drawbacks: 1) Human pilot cost is significant. The schedule of the drone-based track inspection is contingent on the pilot’s availability rather than...
Published: 3/15/2023   |   Inventor(s): Yu Qian, Yi Wang, Chen Chen
Keywords(s): autonomous drone, flight control, image processing, railroad track inspection, self-navigation
Category(s): Engineering and Physical Sciences
2015-671 Underground Shafts for Hydrogen Storage
SummaryResearchers at UCLA have developed an underground drilled shaft concept for storage of hydrogen or other gases.BackgroundOne challenge in creating a hydrogen economy is developing hydrogen gas storage solutions. Increased interest has helped the global hydrogen storage market grow to $2.6 billion in 2016, and it is expected to reach over $5...
Published: 7/19/2023   |   Inventor(s): Adrienne Lavine, Hossein Kavehpour, Dante Simonetti, Richard Wirz, Chen Chen, Gabriela Bran, Gopinath Warrier, Hamarz Aryafar, Jonathon Kennedy, Joshua Jordan, Keith Lovegrove
Keywords(s): Energy & Water
Category(s): Energy & Environment > Energy Generation > Solar, Energy & Environment > Energy Storage
pH-Responsive Polymeric Nanoparticles for Controlled Delivery and Release in Agriculture
Release Encapsulated Pesticides Only Upon Contact with Increased Concentrations of Sugars or Elevated pH LevelsThese nanoparticles release pesticides into the plant only upon contact with elevated concentrations of sugars or elevated pH levels found in the phloem. Citrus greening disease is one of the most serious citrus plant diseases in the world....
Published: 6/27/2021   |   Inventor(s): Gloria Moore, Zhenli He, Brent Sumerlin, Megan Hill, Mingsheng Chen, Shaun Jensen, Sangwoo Park
Keywords(s): Agriculture and Food Sciences, Citrus Greening Disease, controlled, Nanoparticle, polymer, Release
Category(s): Technology Classifications > Agricultural > Insect Control, Technology Classifications > Agricultural > Therapeutics, Technology Classifications > Engineering > Chemical, Technology Classifications > Engineering > Materials
BlueTIME - Bluetooth-based Travel Information Monitoring and Evaluation System
BlueTIME (Bluetooth-Based Travel Information Monitoring and Evaluation System) is a low cost, integrated system for roadway travel time detection, traffic state monitoring, and performance evaluation. BlueTIME detects anonymous MAC addresses from all Bluetooth devices within range (e.g., phones, vehicular Bluetooth systems, headsets, and music players)....
Published: 8/1/2024   |   Inventor(s): Yao-Jan Wu, Kenneth Head, Shu Yang, Ming Chen
Keywords(s):  
Category(s): Technology Classifications > Engineering & Physical Sciences > Communications & Networking > Wireless, Technology Classifications > Engineering & Physical Sciences > Transportation & Automotive > Safety Systems/Driver Enhancements
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