PRODUCT OPPORTUNITIES AND END-USE APPLICATIONS
• Nanopore-based antibody screening system
• Nanopore sensors for antibody detection and identification
• Antibody screening in hybridoma-based antibody production
• Real-time monitoring of antibody production in cell culture
ADVANTAGES
• Simple and fast antibody detection
• Multiplex detection and antibody identification possible
• Capable of identifying antibody subtypes in mixtures of antibodies such as polyclonal antibodies and blood samples.
TECHNOLOGY DESCRIPTION
This invention provides OmpG nanopore-based sensors for antibody screening applications. Each OmpG nanopore is engineered to contain a heterologous peptide sequence in one or more flexible loops of the nanopore, allowing for target-specific binding and detection.
ABOUT THE LEAD INVENTOR
Dr. Min Chen is an Asociate Professor in the Department of Chemistry at the University of Massachusetts Amherst. Her research group focuses on developing engineered protein pores for biosensing applications.
AVAILABILITY:
Available for Licensing and/or Sponsored Research
DOCKET:
UMA 22-057
PATENT STATUS:
Patent Pending
NON-CONFIDENTIAL INVENTION DISCLOSURE
LEAD INVENTOR:
Min Chen, Ph.D.
CONTACT: