Search Results - life+science+research+tools+%3e+antibodies

34 Results Sort By:
Sarcospan Antibodies for Biomedical Application (UCLA Case No. 2024-082)
UCLA researchers in the Department of Integrative Biology and Physiology have developed a set of novel and highly specific sarcospan antibodies for use in basic and translational research. BACKGROUND: Sarcospan (SSPN) is a broadly expressed cell surface 25 kDa transmembrane protein. SSPN is critical for the function of adhesion complexes in skeletal...
Published: 5/8/2024   |   Inventor(s): Rachelle Crosbie, Ekaterina Mokhonova
Keywords(s): Antibodies, Becker muscular dystrophy, Duchenne muscular dystrophy, ELISA, immunoblotting, immunofluorescence, immunoprecipitation, musculoskeletal disorders, sarcospan
Category(s): Life Science Research Tools > Antibodies, Therapeutics > Musculoskeletal Disease
Cellphone-Based Micro-Plate Reader for Point-Of-Care ELISA Testing & High-Throughput and Automated Diagnosis of Antimicrobial Resistance
Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed a cost-effective cellphone-based micro-plate reader to rapidly perform antimicrobial susceptibility testing (AST) with >99% accuracy. Background: Immunoassays are biochemical tests that are conducted to measure the presence and concentration of...
Published: 7/19/2023   |   Inventor(s): Aydogan Ozcan, Dino Di Carlo, Steve Feng, Bingen Cortazar Unzaga, Brandon Berg, Haydar Ozkan, Omai Garner, Kuochao Tseng
Keywords(s): Antibacterial, Antibiotic Resistance, Antibody, Artificial Intelligence, Bacteria, Drug Resistance, ELISA, High-Throughput Screening, Immunoassay, Nanotechnology, Optics, Photonics, Point Of Care, Smartphone
Category(s): Life Science Research Tools, Life Science Research Tools > Antibodies, Diagnostic Markers, Optics & Photonics, Software & Algorithms > Artificial Intelligence & Machine Learning
2021-309-METHODS OF USING SHAPED PARTICLES IN FLOW CYTOMETERS FOR ASSAYS ON B CELLS AND T CELLS
Summary: UCLA researchers in the Department of Bioengineering have developed a platform to sort single cells based on their secreted product at high throughput using commonly accessible lab infrastructure, i.e., flow cytometers. Background: Techniques to sort single cells based on secreted products have the potential to accelerate the development...
Published: 7/19/2023   |   Inventor(s): Dino Di Carlo, Joseph de Rutte, Robert Dimatteo, Maani Archang, Robert Damoiseaux, Doyeon Koo
Keywords(s): Antibody, B Cell, Bioassay, Cell Counting/Imaging, Cellular Differentiation, Cytometry, Flow Cytometry, Fluorescence, Hybridoma Technology, Secretory Component, T Cell, Targets And Assays
Category(s): Life Science Research Tools, Life Science Research Tools > Antibodies, Life Science Research Tools > Cell Lines, Life Science Research Tools > Research Methods, Life Science Research Tools > Other Reagents, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Platforms > Diagnostic Platform Technologies
2019-772: A Single Chain Antibody That Binds Tau Oligomers and Inhibits Seeding by Pathological Extracts From Alzheimer’s Disease
SUMMARYUCLA researchers in the Department of Chemistry & Biochemistry have developed a method for efficiently producing tau oligomers and a single-chain antibody against oligomeric tau protein with potential for theranostic utility in the treatment of Alzheimer’s and other tauopathies.BACKGROUND:Alzheimer’s disease (AD) is the most prevalent...
Published: 9/5/2023   |   Inventor(s): David Eisenberg
Keywords(s): Amyloid, Antibodies, Central Nervous System, Genetic Disease, Life Science Research Tools, Neurodegeneration Alzheimer's Disease Predictive Testing, Tau Protein
Category(s): Life Science Research Tools > Antibodies, Therapeutics > CNS and Neurology
2021-002 System and Methods for Amplified Detection of Molecules on Microparticles
SUMMARYUCLA researchers in the Department of Bioengineering have developed a system to build immunocomplexes, generate and accumulate amplified signals, and perform the signal readout of a digital ELISA using standard benchtop instruments and techniques.BACKGROUNDDigital ELISA allows for the detection and measurement of protein biomarkers at a single-molecule...
Published: 7/19/2023   |   Inventor(s): Dino Di Carlo, Yilian Wang, Vishwesh Nilesh Shah
Keywords(s):  
Category(s): Life Science Research Tools > Research Methods, Life Science Research Tools > Lab Equipment, Life Science Research Tools > Antibodies, Diagnostic Markers > Immunology, Diagnostic Markers > Targets And Assays, Platforms > Diagnostic Platform Technologies
2019-726 AUGMENTATING T-CELL ACTIVATION BY OSCILLATORY FORCES AND ENGINEERED ANTIGEN-PRESENTING CELLS
UCLA researchers in the Department of Pediatrics have developed a suite of novel spherical aAPCs of varying sizes and densities, that can be coupled with an oscillatory stimulus to promote efficient T cell activation: offering the possibility to aptly engineer T cells for a variety of clinical and experimental needs. BACKGROUND:T cells circulate throughout...
Published: 9/5/2023   |   Inventor(s): Manish Butte, Fatemeh Sadat Majedi
Keywords(s): Immunology, Immunotherapy, Life Science Research Tools, Oncology, Oncology Immunotherapy
Category(s): Life Science Research Tools > Antibodies, Life Science Research Tools > Research Methods, Diagnostic Markers > Immunology, Therapeutics > Oncology > Oncology Immunotherapy
2011-464 Polyclonal Antibody Recognizing the Human RIN2 Protein
Innovation RIN2 is a RAS effector protein with guanine nucleotide exchange factor (GEF) activity for RAB5 family GTPases. RIN2 is part of a cerebral cavernous malformations (CCM) signaling complex implicated in sporadic or inherited vascular lesions of the central nervous system. Additionally, RIN2 deficiencies are linked to the human connective tissue...
Published: 7/19/2023   |   Inventor(s):  
Keywords(s):  
Category(s): Life Science Research Tools > Antibodies
2011-418 Novel Monoclonal Antibodies against Neospora Caninum
Summary UCLA researchers have developed a large number of highly specific monoclonal antibodies against the intracellular parasite Neospora caninum that can be used for diagnostic or research purposes.Background Apicomplexan parasites cause a wide array of diseases of medical and veterinary importance including malaria (Plasmodium spp.), toxoplasmosis...
Published: 7/19/2023   |   Inventor(s):  
Keywords(s):  
Category(s): Life Science Research Tools > Antibodies
2010-810 Fusion Protein For Anti-Cd19 Chimeric Antigen Receptor Detection
Summary Researchers at UCLA have developed a fusion protein that can detect immune cells expressing anti-CD19 chimeric antigen receptors with higher specificity and lower background than existing antibodies. Background CD19, a glycoprotein specific to the B-cell lineage, is a target of a number of cancer immunotherapies. Clinical trials testing the...
Published: 7/19/2023   |   Inventor(s):  
Keywords(s):  
Category(s): Life Science Research Tools > Antibodies
2009-592 Anti-S80 Phospho-Specific Mecp2 Antibody
Innovation MeCP2 is a methyl-CpG binding protein that binds methylated DNA to repress gene expression. Mutations in MeCP2 lead to neurodevelopmental disorders, including Rett syndrome, one of the most common causes of mental retardation in females. Phosphorylation of MeCP2 on a highly conserved serine residue (S80) is required for its roles in regulating...
Published: 7/19/2023   |   Inventor(s):  
Keywords(s):  
Category(s): Life Science Research Tools > Antibodies
1 2 3 4