Search Results - anti-infective

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Anti-bacterial Treatments Using Peptide-Based Inhibitors of the STAT3-IL10 Pathway
Abstract: Tuberculosis (TB) is an infectious disease that typically affects the lungs. Current therapies include a panel of antibiotics given over a range of 6-9 months. As a result of the expense of treatment, the extended timeframe needed for effective treatment, and the scarcity of medicines in some developing countries, patient compliance with TB...
Published: 4/8/2024   |   Inventor(s): Nadya Tarasova, Mercedes Gonzalez-Juarreto
Keywords(s): Anti-infective, IL-10, immunomodulatory, Immunotherapy, INTERLEUKIN, STAT3, TUBERCULOSIS
Category(s): Application > Therapeutics, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Immunology, TherapeuticArea > Infectious Disease
Potent and Selective Cyclic Peptide Inhibitors of Phosphoglycerate Mutase as Anti-Infective Agents
Summary – The invention includes compounds and compositions for inhibiting phosphoglycerate mutase (PGM) activity. In some examples, the compounds selectively inhibit cofactor-independent PGM (iPGM). In particular embodiments, the compounds include one or more cyclic peptides. Brief Background – Co-factor independent phosphoglycerate mutase (iPGM)...
Published: 10/28/2024   |   Inventor(s): Patricia Dranchak, Ryan Macarthur, James Inglese
Keywords(s): Agents, Anti-infective, Cyclic, DB2XXX, DB3XXX, Inhibitors, Mutase, Peptide, Phosphoglycerate, POTENT, SELECTIVE, VJXXXX, VQXXXX
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics
Antibacterial activity of natural compounds and their synthetic analogue: A potential new antibiotic with potent activity against multiple drug resistant bacterial pathogens
Our researchers have developed novel compounds that are potential new anti-infective therapeutics useful for treatment against the deadly bacteria MRSA (methicillin-resistant Staphylococcus aureus), VRE (vancomycin-resistant Enterococcus faecium), and several other well-known common infectious agents.Background & Unmet Need:Before antibiotics became...
Published: 8/9/2022   |   Inventor(s): Hossein Salimnia, Fazlul Sarkar, Subhash Padhye, Bernhard Biersack
Keywords(s): Analog or Analogue, Antibiotics, Anti-infective, Anti-microbial, Disease
Category(s): Biologicals, Diseases, Infectious disease, Life Science, Therapeutics
Mannich Bases of Conjugated Styryl Ketones
Detailed Description Human infectious diseases caused by fungi have increased markedly during the past 10 years due mainly to advances in medical care that involve prolonged immune suppression increased use of cytotoxic drugs in cancer chemotherapy and the advent of AIDS. As a result organisms such as Candida albicans have become opportunistic...
Published: 2/27/2022   |   Inventor(s): Jonathan Dimmock, Elias Manavathu
Keywords(s): Anti-infective, Therapeutics
Category(s): Therapeutics, Life Science, Infectious disease