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High-Potency Biased β2-adrenergic Receptor Agonist for Treating Respiratory Diseases
Advantages Ultra-potent β2-adrenergic receptor agonist that stimulates cAMP production with sub-nanomolar potency (EC50 = 0.25nM) Biased signaling profile selectively activates Gαs-mediated cAMP signaling while avoiding β-arrestin2 recruitment, reducing receptor desensitization characteristic of traditional treatments such as albuterol Maintains...
Published: 5/27/2025   |   Inventor(s): Stephen Liggett, Donghwa Kim, Yu Chen, Jesper Madsen, Steven An
Keywords(s): Pharmaceuticals, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals
A Novel Grid-Forming Control Design
Advantages Achieves easy retrofitting from the conventional grid-following control design, by using the same sensors and same inner control and q-axis outer control. Enables weak grid fault ride through and stable operation in series compensated grids. Achieves decoupled voltage and angle tracking through current vector control. Switches between...
Published: 5/13/2025   |   Inventor(s): Lingling Fan, Zhixin Miao
Keywords(s): Electronics
Category(s): Technology Classifications > Engineering > Electrical Engineering
Stability Enhancement Control Technology for Inverter-Based Resources
Advantages: Improves system stability even with well-designed individual IBR controllers Introduces a coordinated voltage feedback control to mitigate oscillations Works across multiple testbeds and conditions, including 3–7 Hz disturbances Proven in both simulations and hardware for real-world performance validation Summary: As inverter-based...
Published: 5/1/2025   |   Inventor(s): Lingling Fan, Zhixin Miao
Keywords(s): Renewable Energy
Category(s): Technology Classifications > Energy & Environment > Energy Engineering
System and Circuit of Compute-in-Memory Design for Genome Alignment
Next-generation sequencing (NGS) technologies have revolutionized genomics research because they enable faster, cheaper and accurate decoding of nucleotide sequences. This has resulted in breakthroughs in diagnostics, disease risk assessment, personalized medicines, screening and more. However, despite all the NGS-related advancements that have been...
Published: 5/1/2025   |   Inventor(s): Deliang Fan, Fan Zhang
Keywords(s): Bio-Technology, Computational Machine, Computing Architecture, Gene, Memory, Personalized medicine
Category(s): Artificial Intelligence/Machine Learning, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Manufacturing/Construction/Mechanical, Semiconductor Devices, Semiconductors, Materials & Processes
System and Circuit of Compute-in-Memory Design for Genome Alignment
Next-generation sequencing (NGS) technologies have revolutionized genomics research because they enable faster, cheaper and accurate decoding of nucleotide sequences. This has resulted in breakthroughs in diagnostics, disease risk assessment, personalized medicines, screening and more. However, despite all the NGS-related advancements that have been...
Published: 5/1/2025   |   Inventor(s): Deliang Fan, Fan Zhang
Keywords(s): Bio-Technology, Computational Machine, Computing Architecture, Gene, Memory, Personalized medicine
Category(s): Artificial Intelligence/Machine Learning, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Manufacturing/Construction/Mechanical, Semiconductor Devices, Semiconductors, Materials & Processes
Adjacent Electrodeposition Method for Compact Metal-Organic Framework Coating on Battery Separators and Other Porous Substrates
Background Electrodeposition is a process that uses an electric current to deposit a layer of metal onto a conductive surface, essentially creating a coating on the material. Electrodeposition helps to protect against corrosion, enhance properties like conductivity, and achieve decorative finished in batteries (in addition to other porous substrates)....
Published: 3/27/2025   |   Inventor(s): Zhaoyang Fan, Xueyan Lin
Keywords(s):  
Category(s): Physical Science, Semiconductors, Materials & Processes, Advanced Materials/Nanotechnology, Energy & Power
Niobium (Nb)-Based Atomically Distributed Electrocatalysts for Water Electrolysis
Background Hydrogen (H2) offers a promising solution in the global energy transition toward net-zero-carbon, particularly for decarbonizing challenging sectors like long-distance transportation, heavy industries, and renewable energy storage. However, most hydrogen is now produced by large-scale natural gas reforming without carbon capture and storage. Water...
Published: 4/3/2025   |   Inventor(s): Zhaoyang Fan, Xueyan Lin
Keywords(s):  
Category(s): Physical Science, Environmental, Applied Technologies
Destructing Organic Compounds in Liquids
VALUE PROPOSITION Per and Poly Fluoroalkyl Substances (PFAS) are a group of human-derived chemicals widely used in consumer products and industry applications that can be toxic. PFAS are difficult to deconstruct and current ways for PFAS destruction present many limitations. These limitations include the systems being ineffective at removing short...
Published: 3/10/2025   |   Inventor(s): Qi Hua Fan
Keywords(s):  
Category(s): Chemicals, Environment
DNAzyme sensor for selective manganese ion detection in biological systems
A selective DNAzyme-based fluorescent sensor detects manganese ions in cells by lighting up when Mn²⁺ binds, allowing precise monitoring of manganese levels for biological research and potential therapies. Background Manganese (Mn²⁺) is an essential trace element integral to numerous biological processes, acting as a vital cofactor for enzymes...
Published: 5/19/2025   |   Inventor(s): Yi Lu, Zhenglin Yang, Huanhuan Fan
Keywords(s):  
Category(s): Life sciences > Biomaterials
Prebiotic Treatment for the Prevention of Multiple Oral Diseases
Inhibits Disease-Causing Bacteria and Restores Balance to the Oral Microbiome This prebiotic agent can prevent and treat oral diseases by eliminating disease-causing bacteria, while simultaneously promoting the growth of healthy bacteria. An estimated 3.9 billion people worldwide suffer from oral diseases such as cavities, oral thrush, peri-mucositis...
Published: 1/31/2025   |   Inventor(s): Lin Zeng, Fan Ren, Jennifer Andrew, Jacqueline Abranches, Josephine Esquivel-Upshaw, Bruna Garcia, Luiz Gonzaga, Robert Burne
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Nutraceutical, Technology Classifications > Medical Devices > Consumable
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