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Systems and Methods for Concurrent Biochemical Immunoassay and Cellular Traction Force Measurement in Hydrogels
This invention relates to a platform that couples bead-based immunoassays with 3D traction force microscopy (TFM) within a single hydrogel substrate to quantify time-resolved biochemical cues and cell-generated mechanical forces at matched locations. This invention allows researchers to directly test how local molecular cues influence cell mechanics...
Published: 3/23/2026   |   Updated: 3/23/2026   |   Inventor(s): Alex McGhee, Kelvin Pond, A Departmental Work
Keywords(s):  
Category(s): Technology Classifications > Imaging & Optics > Sensors and Detection, Technology Classifications > Engineering & Physical Sciences > Photonics, Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Research Tools > Screening assays
Membrane-less, Gravity Independent Liquid-Liquid and Gas-Liquid Extraction and Phase Separation
A membrane-less device enabling liquid-liquid and gas-liquid separation without requiring gravity Background The separation of mixtures of fluid phases, particularly liquid-liquid and gas-liquid extraction, is relevant to many industrial chemical and biochemical processes, including fuels production, pharmaceuticals, and hydrometallurgy. Many solvent...
Published: 3/18/2026   |   Updated: 3/18/2026   |   Inventor(s): Goran Jovanovic, Matthew Coblyn, Jad Touma, Lucas Freiberg, Francis Chukwunta, Lei Li, Cliff Kowall, Bingchen Wang, Yihan Song, Fan Yang, Aigerim Baimoldina
Keywords(s):  
Category(s): Engineering
Anodization Tool for Uniform Titanium Oxide Nanotubes on Non-Conductive Surfaces, Enabling Advanced Dental Implants and Biomedical Devices
Produces Titanium Oxide Nanotubes, Enhancing Dental Implants with Antibacterial and Biocompatible Properties Dental implants and other load-bearing biomedical devices rely heavily on surface properties to achieve long-term stability, osseointegration, and resistance to bacterial colonization. These are important aspects of modern dentistry that impact...
Published: 3/20/2026   |   Updated: 3/16/2026   |   Inventor(s): Josephine Esquivel-Upshaw, Fan Ren, Chao-Ching Chiang
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics
Dark Eye Harvester
This invention involves using an insulated light-proof chamber that allows the harvesting of eyes or another light-sensitive biomaterial without light exposure, allowing visual rhodopsin to regenerate more efficiently. The chamber has a cylindrical shape and is attached to a chest cooler with handles on top to rotate the walls. The chamber has multiple...
Published: 2/9/2026   |   Updated: 2/9/2026   |   Inventor(s): A Departmental Work, Michael Brown
Keywords(s):  
Category(s): Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation, Technology Classifications > Research Tools
Enhanced High Efficiency Zinc-Air Batteries
Invention Description Zinc-air batteries (ZABs) consist of cells that use metallic zinc as the anode, atmospheric oxygen as the cathode and water‑based electrolytes. These batteries have a large appeal due to their low-cost production, sustainable approach (less reliance on rare/toxic metals), and solution for large-scale and slow-cycle energy storage....
Published: 2/26/2026   |   Updated: 11/4/2025   |   Inventor(s): Zhaoyang Fan
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Energy & Power, Physical Science
Advancing High-Throughput Diagnostics With Wash-Free Programmable Toehold Fluorescence Imaging
Streamlines Fluorescence Imaging by Eliminating Buffer Exchanges for Faster Target Analysis This wash-free multiplexed fluorescence bio-imaging aims to revolutionize fluorescence imaging by overcoming the limitations of traditional workflows with programmable toehold probes in situ. Conventional imaging techniques often require time-intensive buffer...
Published: 2/4/2026   |   Updated: 10/9/2025   |   Inventor(s): Fan Hong, Tingyi Zhu
Keywords(s):  
Category(s): Technology Classifications > Engineering > Chemical, Technology Classifications > Human Health Care > Diagnostics
Light-directed nanofabrication technology for precise deposition of nanomaterials
Background Nanofabrication is a pivotal technology in various high-tech industries, including electronics, biomedical devices, and materials science. The ability to precisely deposit colloids, compounds, and molecules enables the creation of intricate micro- and nano-scale structures essential for developing high-performance semiconductors, sensitive...
Published: 1/13/2026   |   Updated: 10/8/2025   |   Inventor(s): Donglei Fan, Hyungmok Joh
Keywords(s):  
Category(s): Physical sciences > Materials
Continuous Whole-Chip 3-Dimensional Dep Cell Sorter and Its Fabrication (Case No. 2012-612)
Summary Researchers at UCLA have developed a continuous, whole-chip, three-dimensional dielectrophoretic (DEP) cell sorting device, integrating multi-layer microfluidics and electrode geometries to sort cells or particles throughout the thickness of a microfluidic chip, not merely at a single plane. Background Microfluidic cell sorting is vital in...
Published: 9/24/2025   |   Updated: 9/24/2025   |   Inventor(s): Pei-Yu Chiou, Yu Jui Fan, Yu Chun Kung, Kuo Wei Huang
Keywords(s):  
Category(s): Life Science Research Tools, Life Science Research Tools > Cell Counting And Imaging, Optics & Photonics, Optics & Photonics > Microscopy, Electrical, Electrical > Imaging
Brain-Targeted Nanoparticles for Delivering Agents to the Brain
The blood brain barrier (BBB) is a highly selective semipermeable complex, and only about 2% of small molecules in the blood can penetrate it. Because of this, drug delivery to the brain is fairly ineffective. Research into receptors expressed on the BBB is promising, however, many receptors (glucose transporter 1, transferrin receptor, LDL-receptor...
Published: 2/26/2026   |   Updated: 8/27/2025   |   Inventor(s): Shu Wang, Zhaoyang Fan
Keywords(s):  
Category(s): Biological Nanotechnology, Diagnostic Assays/Devices, Imaging, Life Science (All LS Techs), Pharmaceuticals, Medical Imaging, Non-Cancer Therapeutics
Ampule-Based Synthesis of Sulfur-Porous Carbon Composites for Lithium-Sulfur Batteries
Background Lithium/sulfur (Li/S) batteries are garnering significant attention as a promising solution for next-generation electrochemical energy storage. Their potential to revolutionize the battery industry stems from several key advantages that address the limitations of current lithium-ion (Li-ion) technology. These advantages include an exceptionally...
Published: 2/26/2026   |   Updated: 8/21/2025   |   Inventor(s): Yoon Hwa, David Wright, Yuhui An
Keywords(s): Chemicals, Energy storage, Engineering, Materials, Nanomaterials, Synthesis
Category(s): Energy & Power, Physical Science, Advanced Materials/Nanotechnology, Semiconductors, Materials & Processes
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