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Tumor-pH–Triggered Doxorubicin Prodrug with On-Demand Shelf-Stable Precursor
This invention introduces a small-molecule doxorubicin prodrug that remains inert in blood and rapidly activates in the mildly acidic tumor microenvironment. Featuring a shelf-stable maleimide pre-prodrug that converts on demand to the ultra-acid-labile DMA form, it enables targeted chemotherapy with improved selectivity, scalable synthesis, and reduced...
Published: 10/10/2025   |   Inventor(s): Ming An, Lan Yao, Vladyslav Nazarenko
Keywords(s): Technologies
Category(s): Campus > Binghamton University
Advancing High-Throughput Diagnostics With Wash-Free Programmable Toehold Fluorescence Imaging
Streamlines Fluorescence Imaging by Eliminating Buffer Exchanges for Faster Target Analysis This wash-free multiplexed fluorescence bio-imaging aims to revolutionize fluorescence imaging by overcoming the limitations of traditional workflows with programmable toehold probes in situ. Conventional imaging techniques often require time-intensive buffer...
Published: 10/9/2025   |   Inventor(s): Fan Hong, Tingyi Zhu
Keywords(s):  
Category(s): Technology Classifications > Engineering > Chemical, Technology Classifications > Human Health Care > Diagnostics
Light-directed nanofabrication technology for precise deposition of nanomaterials
Background Nanofabrication is a pivotal technology in various high-tech industries, including electronics, biomedical devices, and materials science. The ability to precisely deposit colloids, compounds, and molecules enables the creation of intricate micro- and nano-scale structures essential for developing high-performance semiconductors, sensitive...
Published: 10/8/2025   |   Inventor(s): Donglei Fan, Hyungmok Joh
Keywords(s):  
Category(s): Physical sciences > Materials
Continuous Whole-Chip 3-Dimensional Dep Cell Sorter and Its Fabrication (Case No. 2012-612)
Summary Researchers at UCLA have developed a continuous, whole-chip, three-dimensional dielectrophoretic (DEP) cell sorting device, integrating multi-layer microfluidics and electrode geometries to sort cells or particles throughout the thickness of a microfluidic chip, not merely at a single plane. Background Microfluidic cell sorting is vital in...
Published: 9/24/2025   |   Inventor(s): Pei-Yu Chiou, Yu Jui Fan, Yu Chun Kung, Kuo Wei Huang
Keywords(s):  
Category(s): Life Science Research Tools, Life Science Research Tools > Cell Counting And Imaging, Optics & Photonics, Optics & Photonics > Microscopy, Electrical, Electrical > Imaging
Brain-Targeted Nanoparticles for Delivering Agents to the Brain
The blood brain barrier (BBB) is a highly selective semipermeable complex, and only about 2% of small molecules in the blood can penetrate it. Because of this, drug delivery to the brain is fairly ineffective. Research into receptors expressed on the BBB is promising, however, many receptors (glucose transporter 1, transferrin receptor, LDL-receptor...
Published: 8/27/2025   |   Inventor(s): Shu Wang, Zhaoyang Fan
Keywords(s):  
Category(s): Biological Nanotechnology, Diagnostic Assays/Devices, Imaging, Life Science (All LS Techs), Pharmaceuticals, Medical Imaging, Non-Cancer Therapeutics
Ampule-Based Synthesis of Sulfur-Porous Carbon Composites for Lithium-Sulfur Batteries
Background Lithium/sulfur (Li/S) batteries are garnering significant attention as a promising solution for next-generation electrochemical energy storage. Their potential to revolutionize the battery industry stems from several key advantages that address the limitations of current lithium-ion (Li-ion) technology. These advantages include an exceptionally...
Published: 10/30/2025   |   Inventor(s): Yoon Hwa, David Wright, Yuhui An
Keywords(s): Chemicals, Energy storage, Engineering, Materials, Nanomaterials, Synthesis
Category(s): Energy & Power, Physical Science, Advanced Materials/Nanotechnology, Semiconductors, Materials & Processes
Innovative Multifunctional Edible Coating for Enhancing Fresh Produce
Fresh fruits and vegetables (FVs) can cause foodborne diseases as they are able to harbor a variety of human pathogens and parasites. The short shelf life of fresh produce, due in large part to microbial induced spoilage, is a serious problem that costs the food industry billions a year. Further, nutrients, polyphenols and other bioactive compounds...
Published: 7/16/2025   |   Inventor(s): Shu Wang, Zhaoyang Fan
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Agriculture/Animal Health, Life Science (All LS Techs)
Atomically Dispersed Nb-N-C Based Electrocatalyst for Metal-Air Batteries
Background Zn-air batteries (ZABs) are an emerging technology recognized for their environmentally friendly properties, cost-effectiveness, and high energy density. ZABs are reinventing next generation metal air batteries and are considered potential alternatives to lithium-ion batteries, providing a greener alternative. These batteries operate by...
Published: 7/14/2025   |   Inventor(s): Zhaoyang Fan, Xueyan Lin, Bin Wang
Keywords(s):  
Category(s): Physical Science, Environmental, Energy & Power
Combating Potential Misinformation in Journalism: A Hybrid Framework using LLMs and Heuristic Approaches
Background The rapid dissemination of news is an important factor for the global population to stay up to date with current events, or to make well-informed decisions in dynamic sectors like the stock market. Journalists typically include large amounts of quantitative information using data visualization to help enhance accessibility and comprehension...
Published: 6/17/2025   |   Inventor(s): Arlen Fan, Fan Lei, Steven Corman, Ross Maciejewski
Keywords(s):  
Category(s): Artificial Intelligence/Machine Learning, Physical Science, Cybersecurity
Combating Potential Misinformation in Journalism: A Hybrid Framework using LLMs and Heuristic Approaches
Background The rapid dissemination of news is an important factor for the global population to stay up to date with current events, or to make well-informed decisions in dynamic sectors like the stock market. Journalists typically include large amounts of quantitative information using data visualization to help enhance accessibility and comprehension...
Published: 6/17/2025   |   Inventor(s): Arlen Fan, Fan Lei, Steven Corman, Ross Maciejewski
Keywords(s):  
Category(s): Artificial Intelligence/Machine Learning, Physical Science, Cybersecurity
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