Search Results - daniel+diaz

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Human enzyme-mediated depletion of serine in cancer
Engineered human serine dehydratase enzymes are designed to efficiently degrade serine, an amino acid crucial to cancer cell metabolism, and inhibit cancer growth. These enzymes, with improved stability, activity, and bio­availability, offer a targeted cancer treatment option with fewer adverse effects. Background Traditional chemotherapeutic...
Published: 8/29/2024   |   Inventor(s): Everett Stone, Ebru Cayir, Daniel Diaz, Raghav Shroff
Keywords(s):  
Category(s): Life sciences > Therapeutics > Small molecule, Life sciences > Research tools
Revolutionizing plastic recycling: FAST-PETase enzyme variant
Background Plastic waste is a pressing ecological challenge, with a staggering 8.3 billion metric tons produced, of which 6 billion tons become waste. Traditional methods of plastic degradation, such as chemical processes, are costly and generate harmful byproducts. Enzymatic degradation presents a sustainable alternative, with poly (ethylene terephthalate)...
Published: 6/11/2025   |   Inventor(s): Hal Alper, Andrew Ellington, Daniel Diaz, Hongyuan Lu
Keywords(s):  
Category(s): Life sciences > Agriculture, Life sciences > Metabolic engineering
Engineered methyltransferase for microbial production of the Alzheimer’s drug galantamine
­Problem Galantamine is a cholinesterase-inhibiting compound used for the treatment of cognitive decline in mild to moderate cases of Alzheimer’s disease and other memory impairment disorders. Galantamine is a plant alkaloid found in the bulbs and flowers of several species including daffodils, snowdrops, and red spider lilies. Galantamine...
Published: 4/18/2024   |   Inventor(s): Andrew Ellington, Simon d’Oelsnitz, Daniel Diaz
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Research tools > Reagent
Br512: an improved DNA polymerase for isothermal amplification assays
Unmet need Loop-mediated isothermal amplification (LAMP) is a technique that allows for nucleic acid amplification without the need for a thermocycler. This technology enables testing for infections practically anywhere. Testing shortages have exacerbated the COVID-19 pandemic, and there is a high demand for tests that can provide rapid results outside...
Published: 9/12/2025   |   Inventor(s): Andrew Ellington, Andre Maranhao, Sanchita Bhadra, Inyup Paik, Phuoc (Jaydin) Ngo, Daniel Diaz, David R.B. Walker
Keywords(s): COVID-19, Diagnostics, Engineered enzyme, Isothermal amplification, LAMP, Nucleic acid amplification, Point-of-care, Point-of-need, Polymerase
Category(s): Life sciences > Research tools > Reagent