Search Results - sanchita+bhadra

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Unbiased material identification and characterization using proximity ligation assay technology
The technology describes a method for characterizing known or unknown materials using libraries of probes that bind to them. These probes, which can be oligonucleotides or peptides linked to polynucleotide barcodes, are analyzed via sequencing to identify material-specific patterns, enabling the detection and identification of known and unknown materials. Background Characterizing...
Published: 8/2/2024   |   Inventor(s): Andrew Ellington, Sanchita Bhadra, Zachary Wentzell
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform
Low-cost rapid diagnosis of viral diseases
Background/problem Detection of infectious diseases relies on amplification techniques of genetic material such as RNA or DNA. State-of-the-art amplification techniques include RT-PCR and RT-LAMP, both of which use a reverse transcriptase (RT) to amplify RNA. Usually, an RNA strand is reverse transcribed into comple­mentary DNA (cDNA), which is...
Published: 7/8/2024   |   Inventor(s): Andrew Ellington, Inyup Paik, Sanchita Bhadra, Shaunak Kar
Keywords(s):  
Category(s): Life sciences > Research tools > Reagent
Bacterial reagents: stable, low-cost, readily available reagents with no purification requirements
Problem Most molecular biology techniques commonly used in research, biotechnology, healthcare, and education rely heavily on purified functional protein reagents. However, purification of these protein reagents requires substantial investment of time, expertise, equipment, and infrastructure. As a result, this significantly limits the availability...
Published: 11/1/2023   |   Inventor(s): Andrew Ellington, Sanchita Bhadra, Arti Pothukuchy, Michelle Byrom, Raghav Shroff, Jared Ellefson, Jimmy Gollihar
Keywords(s): Diagnostics, Isothermal amplification, Nucleic acid amplification, Point-of-need
Category(s): Life sciences > Research tools > Reagent, Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Therapeutics > Synthetic biology
Br512: an improved DNA polymerase for isothermal amplification assays
Unmet need Loop-mediated isothermal amplification (LAMP) is a technique that allows for nucleic acid amplification without the need for a thermocycler. This technology enables testing for infections practically anywhere. Testing shortages have exacerbated the COVID-19 pandemic, and there is a high demand for tests that can provide rapid results outside...
Published: 11/1/2023   |   Inventor(s): Andrew Ellington, Andre Maranhao, Sanchita Bhadra
Keywords(s): COVID-19, Diagnostics, Engineered enzyme, Isothermal amplification, LAMP, Nucleic acid amplification, Point-of-care, Point-of-need, Polymerase
Category(s): Life sciences > Research tools > Reagent