Search Results - raghav+shroff

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Human enzyme-mediated depletion of serine in cancer
Engineered human serine dehydratase enzymes are designed to efficiently degrade serine, an amino acid crucial to cancer cell metabolism, and inhibit cancer growth. These enzymes, with improved stability, activity, and bio­availability, offer a targeted cancer treatment option with fewer adverse effects. Background Traditional chemotherapeutic...
Published: 8/29/2024   |   Inventor(s): Everett Stone, Ebru Cayir, Daniel Diaz, Raghav Shroff
Keywords(s):  
Category(s): Life sciences > Therapeutics > Small molecule, Life sciences > Research tools
Engineered RNA polymerases and capping enzymes for the expression of 7‑methylguanylate capped RNA
Background Dr. Andrew Ellington and his team have identified and engineered a novel group II intron reverse transcriptase, RT-12. Dr. Ellington is a Professor in Molecular Biosciences, the Nancy Lee and Perry R. Bass Regents Chair in Molecular Biology, and holds the Wilson M. and Kathryn Fraser Research Professorship in Biochemistry at UT Austin. His...
Published: 11/5/2024   |   Inventor(s): Andrew Ellington, Shaunak Kar, Elizabeth Gardner, Jimmy Gollihar, Raghav Shroff
Keywords(s):  
Category(s): Life sciences > Research tools > Reagent
Bacterial reagents: stable, low-cost, readily available reagents with no purification requirements
Problem Most molecular biology techniques commonly used in research, biotechnology, healthcare, and education rely heavily on purified functional protein reagents. However, purification of these protein reagents requires substantial investment of time, expertise, equipment, and infrastructure. As a result, this significantly limits the availability...
Published: 11/1/2023   |   Inventor(s): Andrew Ellington, Sanchita Bhadra, Arti Pothukuchy, Michelle Byrom, Raghav Shroff, Jared Ellefson, Jimmy Gollihar
Keywords(s): Diagnostics, Isothermal amplification, Nucleic acid amplification, Point-of-need
Category(s): Life sciences > Research tools > Reagent, Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Therapeutics > Synthetic biology