Search Results - shaunak+kar

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Engineered prefusion-stabilized RSV fusion proteins and nucleic acids for enhanced vaccines and diagnostics
This technology uses engineered RSV prefusion proteins with specific mutations to boost stability, expression, and shelf life, enabling more effective and affordable RSV vaccines, treatments, and diagnostics in both protein and nucleic acid (e.g., mRNA) formats. Background Respiratory Syncytial Virus (RSV) is a leading cause of severe respiratory...
Published: 1/27/2026   |   Inventor(s): Jason McLellan, Ajit Ramamohan, Jimmy Gollihar, Raghav Shroff, Thomas Segall-Shapiro, Shaunak Kar, Daniel Boutz, Andrew Horton, Nasim Abdi, Daniel Diaz
Keywords(s):  
Category(s): Life sciences > Therapeutics > Vaccines
Engineered RNA polymerases and capping enzymes for the expression of 7‑methylguanylate capped RNA
Background Dr. Andrew Ellington and his team have identified and engineered a novel group II intron reverse transcriptase, RT-12. Dr. Ellington is a Professor in Molecular Biosciences, the Nancy Lee and Perry R. Bass Regents Chair in Molecular Biology, and holds the Wilson M. and Kathryn Fraser Research Professorship in Biochemistry at UT Austin. His...
Published: 1/13/2026   |   Inventor(s): Andrew Ellington, Shaunak Kar, Elizabeth Gardner, Jimmy Gollihar, Raghav Shroff
Keywords(s):  
Category(s): Life sciences > Research tools > Reagent, Life sciences > Therapeutics > Gene therapy
Low-cost rapid diagnosis of viral diseases
Background/problem Detection of infectious diseases relies on amplification techniques of genetic material such as RNA or DNA. State-of-the-art amplification techniques include RT-PCR and RT-LAMP, both of which use a reverse transcriptase (RT) to amplify RNA. Usually, an RNA strand is reverse transcribed into comple­mentary DNA (cDNA), which is...
Published: 1/13/2026   |   Inventor(s): Andrew Ellington, Inyup Paik, Sanchita Bhadra, Shaunak Kar
Keywords(s):  
Category(s): Life sciences > Research tools > Reagent