Search Results - chien-hui+ma

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Machine-learning guided engineering of T7 RNA polymerase and mRNA capping enzyme for enhanced gene expression in eukaryotic systems
This technology uses machine learning to engineer improved enzymes that dramatically boost gene expression in eukaryotic cells, enabling more efficient production of mRNA, proteins, and therapeutics for research, industrial, and medical applications. Background The field of eukaryotic gene expression is foundational to biotechnology, synthetic biology,...
Published: 7/10/2026   |   Updated: 7/10/2026   |   Inventor(s): Andrew Ellington, Daniel Diaz, Seunggyun Woo, Wantae Kim, Kaci Erwin, Ilya Finkelstein, Chien-Hui Ma, Do-Wook Kim
Keywords(s):  
Category(s): Life sciences > Research tools > Reagent, Life sciences > Therapeutics > Gene therapy
Bile Acids and Other Agents that Modulate the Gut Microbiome for the Treatment of Liver Cancer
Abstract: Primary liver tumors and secondary hepatic malignancies are among the leading causes of cancer-related deaths. Liver metastases account for 95% of all hepatic cancers, and the liver is the most common site for organ metastasis in the body. The gut microbiome serves an important role in antitumor immunity regulating the efficacy of chemo- and...
Published: 4/22/2025   |   Updated: 8/2/2023   |   Inventor(s): Tim Greten, Chi Ma
Keywords(s): Bile Acid, Greten, Liver cancer, Natural Killer T Cells, NKT cells
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Application > Therapeutics, Collaboration Sought > Licensing