Search Results - ilya+finkelstein

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Machine-learning guided engineering of T7 RNA polymerase and mRNA capping enzyme for enhanced gene expression in eukaryotic systems
This technology uses machine learning to engineer improved enzymes that dramatically boost gene expression in eukaryotic cells, enabling more efficient production of mRNA, proteins, and therapeutics for research, industrial, and medical applications. Background The field of eukaryotic gene expression is foundational to biotechnology, synthetic biology,...
Published: 7/10/2026   |   Updated: 7/10/2026   |   Inventor(s): Andrew Ellington, Daniel Diaz, Seunggyun Woo, Wantae Kim, Kaci Erwin, Ilya Finkelstein, Chien-Hui Ma, Do-Wook Kim
Keywords(s):  
Category(s): Life sciences > Research tools > Reagent, Life sciences > Therapeutics > Gene therapy
High-throughput detection of single nucleotide polymorphisms (SNPs) via CRISPR-based diagnostic platform
This CRISPR-based technology enables precise detection of single nucleotide polymorphisms (SNPs) in nucleic acids by using programmed mismatches between CRISPR RNA and target nucleic acids, facilitating high-throughput, quantitative, and point-of-care diagnostics. Background Single nucleotide polymorphisms (SNPs) play a crucial role in disease susceptibility,...
Published: 1/13/2026   |   Updated: 10/21/2024   |   Inventor(s): Ilya Finkelstein, Hung-Che Kuo, Chia-Wei Chou
Keywords(s):  
Category(s): Life sciences > Diagnostic, Life sciences > Research tools
Bioinformatics-powered CRISPR-transposon systems for enhanced gene editing and horizontal gene transfer
CRISPR-associated transposons (CASTs) use nuclease-deficient CRISPR-Cas systems for RNA-guided gene insertion, enhancing the gene-editing toolkit by enabling precise DNA integration. Background CRISPR-associated transposons (CASTs) represent a significant advancement in gene-editing technology, originating from the fusion of CRISPR-Cas systems with...
Published: 1/13/2026   |   Updated: 8/8/2024   |   Inventor(s): Ilya Finkelstein, James Rybarski, Kuang Hu, Alexis Hill, Claus Wilke
Keywords(s):  
Category(s): Life sciences > Research tools > Reagent